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Unit ORGANIC CHEMISTRY

Course
Pharmacy
Study-unit Code
55012807
Location
PERUGIA
Curriculum
In all curricula
Teacher
Claudio Santi
CFU
12
Course Regulation
Coorte 2017
Offered
2018/19
Type of study-unit
Obbligatorio (Required)
Type of learning activities
Attività formativa integrata

ORGANIC CHEMISTRY -MOD. I

Code A000705
Location PERUGIA
CFU 6
Teacher Daniela Lanari
Teachers
  • Daniela Lanari - Didattica Ufficiale
  • Luana Bagnoli - Didattica Integrativa
Hours
  • 42 ore - Didattica Ufficiale - Daniela Lanari
  • 6 ore - Didattica Integrativa - Luana Bagnoli
Learning activities Base
Area Discipline chimiche
Sector CHIM/06
Type of study-unit Obbligatorio (Required)
Language of instruction Italian
Contents
Structure of organic molecules, nomenclature, synthesis and reactivity of functional groups, notions of stereochemistry, major reaction mechanisms
Reference texts
Peter C. Vollhardt, Neil E. Schore CHIMICA ORGANICA Zanichelli 4a ed
Educational objectives
Knowledge of the basics of organic chemistry, nomenclature of organic compounds, synthesis and chemistry of the main functional groups with reference also to the stereochemical aspect. Being able to apply the principles acquired to the study of molecules of biochemical and pharmaceutical interest.
Prerequisites
The student should be familiar with the basic notions of general chemistry in particular must have passed the exam of General Chemistry and Analytical Chemistry
Teaching methods
Frontal lectures where the professor will present all the topics of the course, and to teach a correct approach to the type of study required, during the lessons there will be exercises examples
Other information
not available
Learning verification modality
The student will be graded through a written and oral test. The written test will consist in providing the correct nomenclature and configuration of organic molecules and resolution of exercises where it will be required to know how to use the notions learned on synthesis and reactivity. The oral examination will consist of a discussion of the written test and a further evaluation of the student through questions to determine the degree of familiarity with the topics dealt with during the course.
It will be possible to take a partial test at the end of the present course (written and oral), or to take the whole organic chemistry exam together with Chimica Organica Modulo 2
Extended program
Organic molecules structure. Atomic Orbital and Electronic Configuration. Chemical Bonding, Lewis Formulas, Molecular and Hybrid Orbitals, Bond Polarity, Intramolecular Forces, Electrophilic and Nucleophilic Character, Carboanion,Carbocation, Constitutional Isomerism Acids and bases: definition of acids and bases according to Brönsted and Lewis; acid-base equilibria; Alkanes: nomenclature and chemical-physical properties, conformational analysis, radical halogenation. The stereoisomerism Chirality concept, diasteroisomers and enantiomers, racemic mixtures, stereochemical descriptors (R, S), polarimetry, stereoselective and stereospecific reactions. Alkenes: nomenclature and physical-chemical properties, cis, trans, E / Z isomers, Markovnikov rule, Hammond's postulate. Double-bond electrophilic addition reactions, transposition of carbocation. Alkynes: nomenclature and chemical-physical properties, acidity and reactivity. Properties and reactions of halogenoalkanes: nomenclature and physical-chemical properties, SN2 and SN1 substitution reactions, E2, E1, Saytzev and Hoffmann rule parameters that influence the reaction rate of substitution and elimination. Alcohols and thiols:nomenclature and chemical-physical properties, hydrogen bond and acidity, alcohol synthesis: use of organometallic reagents and alcohol reactivity: nucleophilic oxidation and sustitution. Ethers and thioethers: nomenclature and chemical-physical properties, regio-and stereoselectivity in the ring opening of epoxides. Aldehydes and ketones: nomenclature and physical-chemical properties, synthesis and reactivity, acylic nucleophilic addition, keto-enolic tautomerism, oxidation and reduction, acidity of alpha hydrogen, enolate ions reactions.

ORGANIC CHEMISTRY - MOD. 2

Code A000706
Location PERUGIA
CFU 6
Teacher Claudio Santi
Teachers
  • Claudio Santi - Didattica Ufficiale
  • Ornelio Rosati - Didattica Integrativa
Hours
  • 42 ore - Didattica Ufficiale - Claudio Santi
  • 8 ore - Didattica Integrativa - Ornelio Rosati
Learning activities Base
Area Discipline chimiche
Sector CHIM/06
Type of study-unit Obbligatorio (Required)
Language of instruction
Italian
Contents
Structure of organic molecules, nomenclature, synthesis and reactivity of carboxyl derivtives, carbonyl derivatives, aromatic compounds, heterocycles, amines, carbohydrates, amino acids and proteins
Reference texts
Peter C Vollhardt, Neil E Schore
CHIMICA ORGANICA -Zanichelli
4a italian edition from 7a american
Educational objectives
Knowledge of nomenclature and reactivity of gcarboxyl derivtives, carbonyl derivatives, aromatic compounds, heterocycles, amines, carbohydrates, amino acids and proteins, including stereochemical aspects. Being able to apply the acquired principles to the study of molecules of biochemical and pharmaceutical interest.
Prerequisites
The student should be familiar with the basic notions of general chemistry (inorganic and organic), in particular must have passed the exam of General Chemistry and Analytical Chemistry and attended the first part of Organic Chemistry course
Teaching methods
Frontal lectures where the professor will present all the topics of the course, introducing some exercises as example
Other information
Extra exercises will be provided during the course, at the end of the course and before the summer session. Before the other sections, the teacher and the integrative teaching staff will be available to provide students clarification and explanation.
Learning verification modality
The student will be graded through a written and oral test. The written test will consist in providing the correct nomenclature and configuration of organic molecules and resolution of exercises where it will be required to know how to use the notions learned on synthesis and reactivity. The oral examination will consist of a discussion of the written test and a further evaluation of the student through questions to determine the degree of familiarity with the topics dealt with during the course, using a suitable technical language.

The students that have passed the partial test of the "module I" will be admitted only during the first session of exams to a second partial evaluation (written and oral) on the topics of the module II. For all the other students and for all the students after the firs session it will be possible to be examinated (written and oral) on the entire program of the two modules of Organic Chemistry.

For information on support services for students with disabilities visit http://www.unipg.it/disabilita-e-dsa
Extended program
Carboxylic acids
Nomenclature and chemical-physical properties, acidity, synthesis, reactivity: nucleophilic acyl substitution, synthesis of the functional derivatives of carboxylic acids
Functional derivatives of carboxylic acids
Nomenclature and chemical-physical properties, reactivity of anhydrides, phosphoric anhydrides, acyl halides, amides and lactams, esters and thioesters, nitriles, lipids and tensioactive.
P-delocalized systems:
Chemistry of the 2-propenyl (allyl) system, conjugated dienes: addition reactions 1,2 and 1,4 and diels-alder reactions.
Bifunctional systems
A, b-unsaturated carbonyls, a- and b-dicarbonyl compounds, reactivity of activated methylenes.
Benzene and aromatic properties
Aromaticity. Resonance energy. Aromatic electrophilic substitution. Mechanism, regioselectivity, activation and deactivation of the substrate, effect of the main substituents. Aromatic nucleophilic substitution: outline. Phenols and quinones.
Heterocyclic compounds
Nomenclature system, electronic, acid-base properties: pyrrole, furan, thiophene, pyridine, quinoline, isoquinoline and indole, nitrogenous heterocycles in nature: alkaloids. Basic informations on synthesis and reactivity.
The amines
Nomenclature and chemical-physical properties, basicity, synthesis of aliphatic and aromatic amines, reactivity, diazonium salts: synthesis and use.
Carbohydrates
Classification, nomenclature, structure and stereochemistry, properties, projections of Fisher and Haworth, proof of the structure of the aldoses, reactivity; mutarotation, glucosides, disaccharides and polysaccharides.
Amino acids and proteins
Nomenclature, structure and properties, isoelectric point, synthesis of a-aminoacids and peptide synthesis. Protective groups
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