Università degli Studi di Perugia

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Unit PHARMACOKINETICS, GENERAL PHARMACOLOGY AND PHARMACOGNOSY

Course
Pharmacy
Study-unit Code
65003012
Location
PERUGIA
Curriculum
In all curricula
Teacher
Paolo Puccetti
CFU
12
Course Regulation
Coorte 2016
Offered
2018/19
Type of study-unit
Obbligatorio (Required)
Type of learning activities
Attività formativa integrata

PHARMACOKINETICS

Code 65903906
Location PERUGIA
CFU 6
Teacher Roberta Bianchi
Teachers
  • Roberta Bianchi - Didattica Ufficiale
Hours
  • 42 ore - Didattica Ufficiale - Roberta Bianchi
Learning activities Caratterizzante
Area Discipline biologiche e farmacologiche
Sector BIO/14
Type of study-unit Obbligatorio (Required)
Language of instruction Italian
Contents General principles of Pharmacology. Pharmacokinetics: disposition and metabolisms of drugs. Drug development, evaluation of new drugs and principles of therapeutics. Pharmacology for special patient populations.
Reference texts Paoletti, S. Nicosia, F Clementi, G. Fumagalli
Farmacologia generale e molecolare, UTET, Torino
Educational objectives The course of Pharmacokinetics is the first of three teachings concerning Pharmacology. The main goal of education is to provide to the students the pharmacological basis for the understanding of the other two teachings, represented by Pharmacotherapy and biopharmaceuticals and Toxicology. The general pharmacology is the study of the fundamentals of drug action that evaluates the relationship between body and drug, and analyzes the general mechanisms of interaction between the two systems. All the drugs share some general principles that are independent of the nature of the effect and which are common to all the drugs. The main knowledge gained will be related to: 1) absorption, distribution, metabolism and elimination of drugs 2) routes of administration of the drugs 3) bioavailability and bioequivalence. The knowledge gained will enable the student to achieve the following skills: 1) be able to calculate the correct dosage of a drug 2) avoid toxic effects 3) rational use of medicines and achieve maximum efficacy with minimal toxicity
Prerequisites The student who is going to attend the course Pharmacokinetics, general pharmacology and pharmacognosy must have successfully passed the exams of Animal and vegetal biology that are very important for understanding the contents of the course of Pharmacology and the general objectives of learning. It would also be very useful that the student had successfully passed the exam of General physiology, which would allow him to easily understand the path of a drug in the body. The knowledge of these topics is indispensable for the student who wants to follow the course with profit.
Teaching methods The course consists of classroom lectures on all topics of the course. There are also five lessons of two hours each supplementary teaching, at times other than those of normal classes, in which the topics are deepened, with the cooperation of the students themselves in the form of seminars.
Other information Student reception: Friday from 11am to 13am
Learning verification modality The exam includes a written test (multiple choice questions) at the end of the course which consists of 45 questions that students must answer in a two-hour time, designed to ascertaining the level of knowledge and the understanding on the theoretical contents and methodology forming the main subjects the program and the ability to communicate in writing. The written test can also assess a student's ability to identify receptors for drugs, theories of receptor activation, major classes of receptors and their mechanisms of signal transduction, agonists and antagonists frelative to pharmacodynamics; botanical description of drugs and of the methods of preservation, the main drugs active at the level of the cardiovascular, gastrointestinal, central nervous, and urinary systems as regards Pharmacognosy.
Extended program GENERAL PHARMACOLOGY. General pharmacokinetics: passages of drugs across cell membranes; routes of administration and absorption; bioavailability; distribution of drugs in the body; volume of distribution, binding to plasma proteins; drug metabolism; excretion; time-course of drug plasmatic contents (after single or repeated administration).

GENERAL PHARMACOLOGY AND PHARMACOGNOSY

Code 65903806
Location PERUGIA
CFU 6
Teacher Paolo Puccetti
Teachers
  • Paolo Puccetti - Didattica Ufficiale
Hours
  • 42 ore - Didattica Ufficiale - Paolo Puccetti
Learning activities Caratterizzante
Area Discipline biologiche e farmacologiche
Sector BIO/14
Type of study-unit Obbligatorio (Required)
Language of instruction Italian
Contents General principles of Pharmacology. Pharmacodynamics: drug receptors and receptor mechanisms of signal trasduction.
Definition of drug and active principles. Extraction methods. Example of biological active plants
Reference texts R. Paoletti, S. Nicosia, F Clementi, G. Fumagalli
Farmacologia generale e molecolare, UTET, Torino

e
R. Paoletti, S. Nicosia, F Clementi, G. Fumagalli
Farmacologia clinica, UTET, Torino
A. Bruni- Farmacognosia generale e Applicata-Piccin;
Educational objectives The course of General pharmacology and pharmacognosy is the first of three teachings concerning Pharmacology. The main goal of education is to provide to the students the pharmacological basis for the understanding of the other two teachings, represented by Pharmacotherapy and biopharmaceuticals and Toxicology. The general pharmacology is the study of the fundamentals of drug action that evaluates the relationship between body and drug, and analyzes the general mechanisms of interaction between the two systems. All the drugs share some general principles that are independent of the nature of the effect and which are common to all. The main knowledge gained will be related to: 1) Receptors and theories of receptor activation 2) mechanisms of drug action and signal transduction pathways. The knowledge gained will enable the student to achieve the following skills: 1) be able to calculate the correct dosage of a drug 2) avoid toxic effects 3) rational use of medicines and achieve maximum efficacy with minimal toxicity
Knowledge of crude drug and active principles, classes of secondary active metabolites, extraction methods.
Prerequisites The student who is going to attend the course Pharmacokinetics, general pharmacology and pharmacognosy must have successfully passed the exams of Animal and vegetal biology that are very important for understanding the contents of the course of Pharmacology and the general objectives of learning. It would also be very useful that the student had successfully passed the exam of General physiology, which would allow him to easily understand the path of a drug in the body. The knowledge of these topics is indispensable for the student who wants to follow the course with profit.
Basic knowledge of Plant Biology .
Teaching methods The course consists of classroom lectures on all topics of the course. There are also five lessons of two hours each with supplementary teaching, at times other than those of normal classes, in which the topics are further discussed, with the cooperation of the students themselves in the form of seminars.
Other information compulsory
Learning verification modality The exam includes a written test (multiple choice questions) at the end of the course which consists of 45 questions that students must answer in a two-hour time, designed to ascertaining the level of knowledge and the understanding on the theoretical contents and methodology forming the main subjects the program and the ability to communicate in writing. The written test can also assess a student's ability to identify receptors for drugs, theories of receptor activation, major classes of receptors and their mechanisms of signal transduction, agonists and antagonists frelative to pharmacodynamics; botanical description of drugs and of the methods of preservation, the main drugs active at the level of the cardiovascular, gastrointestinal, central nervous, and urinary systems as regards Pharmacognosy.
Extended program General pharmacodynamics: targets and mechanisms of drug action; receptors, classification of membrane receptors, intracellular receptors, dose-response curve; agonists, partial agonists, antagonists;
Latex and resins. Medicinal plants and crude drugs. Cultivation, harvesting, drying, preparation of medicinal plants. Extraction methods (enfleurage, distillation and solvent extraction). Phytocomplex and isolated active compounds. Phytotoxicity. Conservation of drugs.
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