Università degli Studi di Perugia

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Unit PHYSIOLOGY

Course
Biological sciences
Study-unit Code
55042808
Curriculum
In all curricula
Teacher
Fabio Franciolini
Teachers
  • Fabio Franciolini - Didattica Ufficiale
Hours
  • 56 ore - Didattica Ufficiale - Fabio Franciolini
CFU
8
Course Regulation
Coorte 2016
Offered
2018/19
Learning activities
Caratterizzante
Area
Discipline fisiologiche e biomediche
Sector
BIO/09
Type of study-unit
Obbligatorio (Required)
Type of learning activities
Attività formativa monodisciplinare
Language of instruction
Italian
Contents

Cellular and molecular basis of cell excitability, synaptic transmission and muscle contraction
Reference texts

Fisiologia. Edi.Ermes, Milano - 2011. A cura di Egidio D'Angelo e Antonio Peres
Educational objectives

The course tackle the basic aspects of the mechanisms involved in cell excitability, and muscle contraction. The strongly interactive lectures will instill - that's the objective - in students the attitude and needs towards a rigorous approach of the fundamentals underlying each process, mechanism and function, the only one leading to the development of a conscious attitude towards things.
Prerequisites

Basic knowledge of Physics, Chemistry, Biology
Teaching methods

Class lectures, lab classes
Other information

N/A
Learning verification modality

Oral exam to evaluate the presentation ability, the logical approach to science, and the knowledge of the field
Extended program

1 - Central issues in Physiology Structure-function relationship Organizational levels and reductionism Omeostasis 3 – Cell membrane and transport Intra and extracellular environment Membrane permeation Active transport 4 – Membrane electrical processes Nernst equation Donnan equilibrium Generation of membrane potential 5 – Neural cells and signals Cell types of the nervous system Electrical signals All-or-nothing impulse Action potential Action potential propagation 6 – Ion channels Structure of ion channels and receptors Structure of voltage-gated channels Conformational transition of ion channels Voltage-dependent gating Ligand-dependent gating 7 – Cell communication Signal transduction Prevalent ligand types Seven TM receptors Chemical neurotransmission Ionotropic and metabotropic receptors 8 – Neurotransmission and synaptic plasticity Properties of chemical synapses Sequence of events in neurotransmission Calcium signals in presynaptic terminal Neurotransmitter release and reuptake Postsynaptic receptor activation Synaptic plasticity 10 – Muscle contration Muscle contraction Structure of skeletal muscle fibers Structure-function relationship in muscle Molecular mechanism of muscle contration Modulation of contraction and role of calcium E-C coupling in skeletal muscle and in myocardium General properties of smooth muscle
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