Unit TOXICOLOGY

Course
Pharmacy
Study-unit Code
65258708
Location
PERUGIA
Curriculum
In all curricula
Teacher
Massimo Allegrucci
Teachers
  • Massimo Allegrucci - Didattica Ufficiale
  • Massimo Allegrucci - Didattica Integrativa
Hours
  • 56 ore - Didattica Ufficiale - Massimo Allegrucci
  • 10 ore - Didattica Integrativa - Massimo Allegrucci
CFU
8
Course Regulation
Coorte 2015
Offered
2018/19
Learning activities
Caratterizzante
Area
Discipline biologiche e farmacologiche
Sector
BIO/14
Type of study-unit
Obbligatorio (Required)
Type of learning activities
Attività formativa monodisciplinare
Language of instruction
Italian
Contents
Principles of Toxicology. Mutagenesis. Carcinogenesis. Teratogenesis. Adverse reactions to drugs and herbal remedies. Definitions, classification of ADRs. Pharmacovigilance of drug and herbal medicine. Pharmacogenetics e Toxicogenetics. Detoxification of xenobiotics. Substance abuse. Drugs and pregnancy. Toxicology of prions. QT prolongation.
Reference texts
1. Droghe e farmaci psicoattivi
Robert M. Julien, Claire D. Advokat, Joseph E. Comaty
Zanichelli, 2012 - 688 pagine


2. Tossicologia. Principi e applicazione all'uso dei farmaci e dei prodotti della salute
Piera Ghi, Massimo Allegrucci, Antonello Di Paolo
Minerva Medica, 2009 - Medical - 304 pages

3. Casarett & Doull Elementi di Tossicologia
A cura di Patrizia Hrelia, Giorgio Cantelli Forti
Casa Editrice Ambrosiana. Distribuzione esclusiva Zanichelli
2013
Educational objectives
The aim is to transfer to future pharmacists the basics of toxicological knowledge necessary for the proper use and dispensing of drugs, herbal remedies, and related products.
Prerequisites
in order to be able to understand and apply the knowledge and methodology described within the course the student must have passed the Biology, Biochemistry and General Pharmacology exams.
Teaching methods
Seminar lectures with audiovisual material in order to engage students in a general discussion.
all the course material in digital format is made available at the first lesson
Other information
Discussion of clinical cases of adverse drug reactions with the aim to describe the involved mechanism and the risk management.
Learning verification modality
The exam consists of an oral test about the issues proposed during the class.
In order to put the student at ease the test begins with a subjet of his chose.
The duration of the test depend on the performance of the student, but is never less than 30 minutes
Extended program
Principles of Toxicology: subjects of toxicology, exposure characteristics, risk assessment, types of adverse effects. Dose-response relationships, threshold effects, non-threshold effects, hormesis.
Mutagenesis: types of mutations, repair systems.
Carcinogenesis: stages of carcinogenesis, oncogenes and tumor suppressor genes: p53 ras and
Teratogenesis, major teratogenic substances: thalidomide, DES and alcohol.
Adverse reactions to drugs and herbal remedies .
Definitions, classification of ADRs.
Pharmacovigilance of drug and herbal medicine. Pharmacogenetics, Toxicogenetics.
Detoxification of xenobiotics, detoxification mechanisms, genetic polymorphisms.
Substance abuse. Drugs and pregnancy. Toxicology of prions. QT prolongation.