Università degli Studi di Perugia

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Unit BIOTECHNOLOGICAL DRUGS

Course
Medical, veterinary and forensic biotechnological sciences
Study-unit Code
A001768
Curriculum
In all curricula
Teacher
Simona Ronchetti
Teachers
  • Simona Ronchetti - Didattica Ufficiale
  • Oxana Bereshchenko - Didattica Ufficiale (Codocenza)
Hours
  • 40 ore - Didattica Ufficiale - Simona Ronchetti
  • 12 ore - Didattica Ufficiale (Codocenza) - Oxana Bereshchenko
CFU
6
Course Regulation
Coorte 2019
Offered
2019/20
Learning activities
Caratterizzante
Area
Discipline medico-chirurgiche e riproduzione umana
Sector
BIO/14
Type of study-unit
Obbligatorio (Required)
Type of learning activities
Attività formativa monodisciplinare
Language of instruction
english
Contents
Study of biotech drugs: from production to final formulation, by analysing the safety and efficacy of the product. Knowledge of the biotech drus that are in use in therapy with particular attention at the biosimilar problem.
Reference texts
There’s still no available book in italian so far, but some English written books will be suggested during the first lesson. All slides presented during the face-to face lessons will be available to the students with additional scientific literature  articles provided at the moment.
Educational objectives
This course aims at allowing the student to acquire the knowledge about the rational production of a biotech drug.Specifically:-          Aim of the production of a biotech drug-          Methodologies in the production of both protein and nucleic acid drugs-          Methods in the quality control of a biotech drug; -Antibodies as biotech drugs, -Knowledge of the main biotech drugs in use. Such principles will be analyzed during the exam as well as the ability to design a biotech drug.
Prerequisites
Knowledge of principles of general pharmacology
Teaching methods
The course is organised as follows:-face-to-face lessons with particular attention to a productive debate between the lecturer and the students about all topics of the course- laboratory practice during which the students can apply some methodologies learned during the course, within the research projects of the lab
Other information
face-to-face lessons and lab are optional
Learning verification modality
Written exam with multiple choice; possibility to complete with an oral exam
Extended program
General principles, RNA drugs, protein and antibodies as drugs; systems of recombinant proteins, methos for the production of biotech drugs, purification and final product formulation, pharmacokinetics of biotech drugs, specific biotech drugs (cytokines, insulin, growth factors, recombinant blood products, monoclonal antibodies) and their therapeutic use, recombinant vaccines, biosimilar drugs.
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