Unit MEDICINAL CHEMISTRY II
- Course
- Chemistry and technology of drugs
- Study-unit Code
- 65004609
- Location
- PERUGIA
- Curriculum
- In all curricula
- Teacher
- Maura Marinozzi
- Teachers
-
- Maura Marinozzi
- Hours
- 72 ore - Maura Marinozzi
- CFU
- 9
- Course Regulation
- Coorte 2019
- Offered
- 2022/23
- Learning activities
- Caratterizzante
- Area
- Discipline chimiche, farmaceutiche e tecnologiche
- Academic discipline
- CHIM/08
- Type of study-unit
- Obbligatorio (Required)
- Type of learning activities
- Attività formativa monodisciplinare
- Language of instruction
- Italian
- Contents
- Principles of medicinal chemistry of the following therapeutic classes: cardiovascular agents, diuretics, chemioterapics, steroidal hormones, nonsteroidal anti-inflammatory agents.
- Reference texts
- 1. Foye's Principi di Chimica farmaceutica-(V Ed. It.)-Piccin Ed.
2. Chimica farmaceutica a cura di A. Gasco, F. Gualtieri, C. Melchiorre. Ed. Casa Editrice Ambrosiana.
3.
Wilson and Gisvold's
Chimica farmaceutica. Casa Editrice Ambrosiana.
4. Graham L. Patrick
Chimica Farmaceutica.
EdiSES Editore.
5. G. Greco-Farmaci antibatterici-Loghia Ed. - Educational objectives
- It is expected that the student, at the end of the course, was able to have acquired the tools for understanding, on a molecular basis, the relationship between the structures of the classes of drugs in the program, their metabolism, their biological activity and their possible toxicity. It is also expected that the student knew and was able to draw the chemical structure of the main drugs, was able to denominate the drugs using IUPAC nomenclature.
- Prerequisites
- In order to be able to understand the contents presented within the Course, the student must have attended Medicinal Chemistry I and Organic Chemistry II Courses. Moreover, it would be good if the student was successfully passed the corresponding exams.
- Teaching methods
- Lectures
- Learning verification modality
- The exam includes an oral test of duration of about 40-45 minutes aimed at ascertaining the level of knowledge and understanding achieved by student on the theoretical contents listed in the program. The student is required to accompany the discussion by writing structures, syntheses, nomenclature of the compounds on the blackboard. The oral exam will also evaluate the communication skills of the student, the propriety of language, the ability of organization of speech and the ability to make connections between disciplines.
Students coming from abroad in the frame of exchange programs may chose to be examined by a written test in Italian or English - Extended program
- Principles of medicinal chemistry of the following therapeutic classes: cardiovascular agents, diuretics, chemioterapics, steroidal hormones, nonsteroidal anti-inflammatory agents.
From cholesterol to steroidal hormones. Structure and chemichal names of different classes of steroids. Androgens: structure, biosynthesis, metabolism and physiological effects. Androgenic versus anabolic effects. Anabolic agents and doping. Anti-androgens. 5a-reductase inhibitors. Estrogens: chemichal classes, biosynthesis, metabolism, physiological effects. Menstrual cycle. Oral estrogens