Unit ORGANIC CHEMISTRY I
- Course
- Pharmacy
- Study-unit Code
- A002951
- Location
- PERUGIA
- Curriculum
- In all curricula
- Teacher
- Daniela Lanari
- Teachers
-
- Daniela Lanari
- Hours
- 42 ore - Daniela Lanari
- CFU
- 6
- Course Regulation
- Coorte 2022
- Offered
- 2022/23
- Learning activities
- Base
- Area
- Discipline chimiche
- Academic discipline
- CHIM/06
- Type of study-unit
- Obbligatorio (Required)
- Type of learning activities
- Attività formativa monodisciplinare
- Language of instruction
- Italian
- Contents
- Structure of organic molecules, nomenclature, synthesis and reactivity of functional groups, notions of stereochemistry, major reaction mechanisms
- Reference texts
- Peter C. Vollhardt, Neil E. Schore CHIMICA ORGANICA Zanichelli 4a ed
Brown, Iverson, Anslyn, Foote CHIMICA ORGANICA Edises, VI edizione - Educational objectives
- Knowledge of the basics of organic chemistry, nomenclature of organic compounds, synthesis and chemistry of the main functional groups with reference also to the stereochemical aspect. Being able to apply the principles acquired to the study of molecules of biochemical and pharmaceutical interest.
- Prerequisites
- The student should be familiar with the basic notions of general chemistry in particular must have passed the exam of General and Inorganic Chemistry
- Teaching methods
- Frontal lectures where the professor will present all the topics of the course, and to teach a correct approach to the type of study required, during the lessons there will be exercises examples
- Other information
- not available
- Learning verification modality
- The student will be graded through a written and oral test. The student will be asked to provide the correct nomenclature and configuration of organic molecules and to resolve exercises using notions he has learned on synthesis and reactivity. Changes in grading may be applied according to the COVID pandemic situation
- Extended program
- Organic molecules structure. Atomic Orbital and Electronic Configuration. Chemical Bonding, Lewis Formulas, Molecular and Hybrid Orbitals, Bond Polarity, Intramolecular Forces, Electrophilic and Nucleophilic Character, Carboanion,Carbocation, Constitutional Isomerism Acids and bases: definition of acids and bases according to Brönsted and Lewis; acid-base equilibria; Alkanes: nomenclature and chemical-physical properties, conformational analysis, radical halogenation. The stereoisomerism Chirality concept, diasteroisomers and enantiomers, racemic mixtures, stereochemical descriptors (R, S), polarimetry, stereoselective and stereospecific reactions. Alkenes: nomenclature and physical-chemical properties, cis, trans, E / Z isomers, Markovnikov rule, Hammond's postulate. Double-bond electrophilic addition reactions, transposition of carbocation. Alkynes: nomenclature and chemical-physical properties, acidity and reactivity. Properties and reactions of halogenoalkanes: nomenclature and physical-chemical properties, SN2 and SN1 substitution reactions, E2, E1, Saytzev and Hoffmann rule parameters that influence the reaction rate of substitution and elimination. Alcohols and thiols:nomenclature and chemical-physical properties, hydrogen bond and acidity, alcohol synthesis: use of organometallic reagents and alcohol reactivity: nucleophilic oxidation and substitution. Ethers and thioethers: nomenclature and chemical-physical properties, regio-and stereoselectivity in the ring opening of epoxides. Amines: nomenclature and chemical-physical properties, synthesis and uses.