Unit ORGANIC CHEMISTRY I

Course
Pharmacy
Study-unit Code
A002951
Location
PERUGIA
Curriculum
In all curricula
Teacher
Daniela Lanari
Teachers
  • Daniela Lanari
Hours
  • 42 ore - Daniela Lanari
CFU
6
Course Regulation
Coorte 2022
Offered
2022/23
Learning activities
Base
Area
Discipline chimiche
Academic discipline
CHIM/06
Type of study-unit
Obbligatorio (Required)
Type of learning activities
Attività formativa monodisciplinare
Language of instruction
Italian
Contents
Structure of organic molecules, nomenclature, synthesis and reactivity of functional groups, notions of stereochemistry, major reaction mechanisms
Reference texts
Peter C. Vollhardt, Neil E. Schore CHIMICA ORGANICA Zanichelli 4a ed
Brown, Iverson, Anslyn, Foote CHIMICA ORGANICA Edises, VI edizione
Educational objectives
Knowledge of the basics of organic chemistry, nomenclature of organic compounds, synthesis and chemistry of the main functional groups with reference also to the stereochemical aspect. Being able to apply the principles acquired to the study of molecules of biochemical and pharmaceutical interest.
Prerequisites
The student should be familiar with the basic notions of general chemistry in particular must have passed the exam of General and Inorganic Chemistry
Teaching methods
Frontal lectures where the professor will present all the topics of the course, and to teach a correct approach to the type of study required, during the lessons there will be exercises examples
Other information
not available
Learning verification modality
The student will be graded through a written and oral test. The student will be asked to provide the correct nomenclature and configuration of organic molecules and to resolve exercises using notions he has learned on synthesis and reactivity. Changes in grading may be applied according to the COVID pandemic situation
Extended program
Organic molecules structure. Atomic Orbital and Electronic Configuration. Chemical Bonding, Lewis Formulas, Molecular and Hybrid Orbitals, Bond Polarity, Intramolecular Forces, Electrophilic and Nucleophilic Character, Carboanion,Carbocation, Constitutional Isomerism Acids and bases: definition of acids and bases according to Brönsted and Lewis; acid-base equilibria; Alkanes: nomenclature and chemical-physical properties, conformational analysis, radical halogenation. The stereoisomerism Chirality concept, diasteroisomers and enantiomers, racemic mixtures, stereochemical descriptors (R, S), polarimetry, stereoselective and stereospecific reactions. Alkenes: nomenclature and physical-chemical properties, cis, trans, E / Z isomers, Markovnikov rule, Hammond's postulate. Double-bond electrophilic addition reactions, transposition of carbocation. Alkynes: nomenclature and chemical-physical properties, acidity and reactivity. Properties and reactions of halogenoalkanes: nomenclature and physical-chemical properties, SN2 and SN1 substitution reactions, E2, E1, Saytzev and Hoffmann rule parameters that influence the reaction rate of substitution and elimination. Alcohols and thiols:nomenclature and chemical-physical properties, hydrogen bond and acidity, alcohol synthesis: use of organometallic reagents and alcohol reactivity: nucleophilic oxidation and substitution. Ethers and thioethers: nomenclature and chemical-physical properties, regio-and stereoselectivity in the ring opening of epoxides. Amines: nomenclature and chemical-physical properties, synthesis and uses.
Condividi su