Unit GENERAL AND METABOLIC BIOCHEMISTRY
- Course
- Pharmacy
- Study-unit Code
- 65012012
- Location
- PERUGIA
- Curriculum
- In all curricula
- Teacher
- Elisabetta Albi
- Teachers
-
- Elisabetta Albi
- Carmela Conte
- Hours
- 84 ore - Elisabetta Albi
- 6 ore - Carmela Conte
- CFU
- 12
- Course Regulation
- Coorte 2016
- Offered
- 2017/18
- Learning activities
- Caratterizzante
- Area
- Discipline biologiche e farmacologiche
- Academic discipline
- BIO/10
- Type of study-unit
- Obbligatorio (Required)
- Type of learning activities
- Attività formativa monodisciplinare
- Language of instruction
- Italian
- Contents
- The General and Systematic Biochemistry course introduces the student to the structure and functions of molecules of biological interest, their metabolism and their metabolic interactions and their role in various organs and tissues.
- Reference texts
- I principi di Biochimica di Lehninger – David L et al., Zanichelli
- Educational objectives
- Students must achieve a high level of knowledge of the structure of biological molecules (glucids lipids, proteins and nucleic acids), the functioning of enzymes, the anabolic and catabolism metabolism of macromolecules, structure and function of vitamins, trace elements and hormones and their role in the different metabolisms, metabolisms in different organs and tissues.
- Prerequisites
- It is indispensable to have to have passed the exam of organic chemistry
- Teaching methods
- Frontal lectures with projection of images
- Learning verification modality
- Written exams in itinere and final oral exam
- Extended program
- Introduction to the course: physics and chemistry recalls for biochemistry
The water, its ionization, weak acids and weak bases, buffer systems, water as reagent
Amino acids, peptides and proteins, protein denaturation, structure and function of the different proteins (receptors, signaling proteins, immunoglobulins, muscle proteins)
Enzymatic proteins: physical-chimical properties, enzyme kinetics, examples of regulatory enzymes
Bioenergetics : chemical equations, transfer of phosphate groups and ATP, ossidoreduction reactions
Signal transduction
Glucosides: monosaccharides, disaccharides, polisaccharides, proteoglicans, glycoproteins, and glycosphingolipids, saccharide code
Lipids: energetic, structural and signal lipids
Nucleic acids: structure and functions
Vitamins
Minerals
Glucoside metabolism: glycolysis, gluconeogenesis, pentose phosphate pathway, glycogen synthesis, regulatory mechanisms
Lipid metabolism: catabolism and anabolism of fatty acids, triglycerides, phospholipids, sphingolipids and cholesterol
Amino acid and protein metabolism: oxidation of amino acids and urea production, biosynthesis of amino acids, protein synthesis and degradation
Nucleotide metabolism: synthesis and degradation
The Krebs cycle and oxidative phosphorylation
Ketonic bodies
Metabolism roles in different organs and tissues