Unit PHARMACOLOGY
- Course
- Biotechnology
- Study-unit Code
- 55606012
- Curriculum
- In all curricula
- Teacher
- Stefano Bruscoli
- CFU
- 12
- Course Regulation
- Coorte 2020
- Offered
- 2022/23
- Type of study-unit
- Opzionale (Optional)
- Type of learning activities
- Attività formativa integrata
CELLULAR AND MOLECULAR PHARMACOLOGY
| Code | A000417 |
|---|---|
| CFU | 6 |
| Teacher | Stefano Bruscoli |
| Teachers |
|
| Hours |
|
| Learning activities | Affine/integrativa |
| Area | Attività formative affini o integrative |
| Academic discipline | BIO/14 |
| Type of study-unit | Opzionale (Optional) |
| Language of instruction | Italian |
| Contents | Pharmacological modulation of the immune system and of cellular and molecular functions. |
| Reference texts | - F. Rossi, V. Cuomo, C. Riccardi, Pharmacology: Basic principles and therapeutic applications, Fourth Edition, published by Minerva Medica - F. Clementi, G. Fumagalli, General and Molecular Pharmacology, Fourth Edition, UTET |
| Educational objectives | This course aims to provide objective, in addition to the basic concepts on pharmacology, more detailed and current knowledge about cellular and molecular mechanisms of drug action. For a more modern therapeutic application, you provide information on the pharmacological modulation of cellular responses, aspects of molecular receptors on the modulation of intracellular signal transduction mechanisms and pharmacological modulation of gene expression. |
| Prerequisites | In order to achieve the intended learning outcomes of the student must have a solid background in anatomy , physiology and general pathology . It must also comply with the prerequisites in the Academic Regulations. |
| Teaching methods | Theoretical lectures and practical and virtual laboratories |
| Other information | The course rate is not mandatory but is recommended. |
| Learning verification modality | The test, unless new indications, will be oral and will take place as described in the regulation of exams present in the "didattica in telematica" of the UNIPG WEB site. When it will be possible the test could be written, as follows: The written exam consists of a number of multiple choice quiz with five possible answers of which only one is correct ; For the evaluation of the test takes into account the following criteria : - 1 point for each correct answer ; - 0 points for each incorrect answer ; - 0 points for each question not answered ; The total exam duration time is 45 minutes. The written exam is preliminary to the oral examination. An oral examination is accepted with a written test score higher than or equal to 18/30. |
| Extended program | Modulation of gene expression. Pharmacologic modulation of immune system: NSAIDs, SAIDs and immunosuppressive drugs. Pharmacologic control of transport through cell membranes. Proteolysis control. Cell proliferation control. Cell metabolism control. Pharmacologic control of synaptic function. Drugs and microbioma. Gene editing. Immunotherapy. Epigenetics in pharmacology. |
GENERAL AND CLINICAL PHARMACOLOGY
| Code | A000416 |
|---|---|
| CFU | 6 |
| Teacher | Stefano Bruscoli |
| Teachers |
|
| Hours |
|
| Learning activities | Affine/integrativa |
| Area | Attività formative affini o integrative |
| Academic discipline | BIO/14 |
| Type of study-unit | Opzionale (Optional) |
| Language of instruction | Italian |
| Contents | The course will provide the basics of pharmacology and will propose not only the drug as a therapeutic tool, but also as a means of investigation to deepen knowledge about biological phenomena at the cellular and molecular level in order to design new drugs |
| Reference texts | - F. Rossi, V. Cuomo, C. Riccardi, Pharmacology: Basic principles and therapeutic applications, Fourth Edition, published by Minerva Medica - F. Clementi, G. Fumagalli, General and Molecular Pharmacology, Fourth Edition, UTET |
| Educational objectives | This course aims to provide objective, in addition to the basic concepts on pharmacology, more detailed and current knowledge about cellular and molecular mechanisms of drug action. For a more modern therapeutic application, you provide information on the pharmacological modulation of cellular responses, aspects of molecular receptors on the modulation of intracellular signal transduction mechanisms and pharmacological modulation of gene expression.In particular, the biotechnology skills that are expected are: Knowledge and understanding of techniques for the production, analysis and control of drugs obtained through biotechnological processes; Knowledge of the general principles of pharmacology in relation to the design of drugs and, in general, of bioactive molecules obtained through biotechnological processes. Structure and biological properties of cells and animal and plant tissues. |
| Prerequisites | In order to achieve the intended learning outcomes of the student must have a solid background in anatomy , physiology and general pathology . It must also comply with the prerequisites in the Academic Regulations. |
| Teaching methods | Theoretical lectures and practical and virtual laboratories |
| Other information | The course rate is not mandatory but is recommended. |
| Learning verification modality | The test, unless new indications, will be oral and will take place as described in the regulation of exams present in the "didattica in telematica" of the UNIPG WEB site. When it will be possible the test could be written, as follows: The written exam consists of a number of multiple choice quiz with five possible answers of which only one is correct ; For the evaluation of the test takes into account the following criteria : - 1 point for each correct answer ; - 0 points for each incorrect answer ; - 0 points for each question not answered ; The total exam duration time is 45 minutes. The written exam is preliminary to the oral examination. An oral examination is accepted with a written test score higher than or equal to 18/30. |
| Extended program | General Principles Definition of medication Origin and classification of drugs Pharmacokinetics Features of the main cellular barriers Passage of drugs across cell membranes General Rules on the absorption of drugs Routes of administration Enteral routes Parenteral systemic routes Other routes Absorption, bioavailability Absorption kinetics Distribution Apparent volume of distribution Plasma protein binding of drugs Factors that influence the speed distribution Metabolism General principles Enzymatic reactions of phase I Phase II enzymatic reactions Factors that may affect drug metabolism Enzyme induction and repression Elimination The concept of half-life Renal excretion of drugs Hepatic excretion and enterohepatic Main pharmacokinetic parameters Pharmacodynamics Molecular structure of receptors and mechanisms of signal transduction The receptor channel G protein-coupled receptors The receptors for growth factors The receptors for cytokines Receptors that mediate cell adhesion Intracellular receptors Drug-receptor interaction Features of the interaction drug-receptor Relation between drug-receptor interaction and quantitative responses to drugs Agonists, antagonists, partial agonists and inverse Dose-response curves and curves quantal Affinity, potency, efficacy, therapeutic index Modulation of receptor responses Mechanisms of tolerance and addiction to drugs Special Pharmacology, examples of some classes of drugs Factors affecting drug response Factors related to the drug Factors related to patient Drug interactions Research and drug development Research strategies The research phases The stages of development Biotech drugs Development of biotech drugs Production of drugs and genetic engineering The main biotech drugs in use; Vaccines |