Unit PHARMACEUTICAL CHEMISTRY
- Course
- Chemistry
- Study-unit Code
- 65004010
- Curriculum
- In all curricula
- Teacher
- Violetta Cecchetti
- Teachers
-
- Violetta Cecchetti
- Hours
- 42 ore - Violetta Cecchetti
- CFU
- 6
- Course Regulation
- Coorte 2020
- Offered
- 2022/23
- Learning activities
- Affine/integrativa
- Area
- Attività formative affini o integrative
- Academic discipline
- CHIM/08
- Type of study-unit
- Opzionale (Optional)
- Type of learning activities
- Attività formativa monodisciplinare
- Language of instruction
- Italian
- Contents
- Introduction to general medicinal chemistry. The main molecular targets and mechanism of action of drugs. Drug discovery and development.
- Reference texts
- 1.PDF files of lessons (UNISTUDIUM) https://www.unistudium.unipg.it/unistudium/login/index.php
2.Foye’s - PRINCIPI DI CHIMICA FARMACEUTICA (Casa editrice Piccin), 2014 (sesta edizione)
3. Patrick L. Graham - CHIMICA FARMACEUTICA (Edises), 2015 (terza edizione)
4. Gasco, Gualtieri, Melchiorre - CHIMICA FARMACEUTICA (Ambrosiana – Zanichelli), 2019 (seconda edizione) - Educational objectives
- The fundamental objective of the course is to introduce the student to the general concepts of medicinal chemistry and provide him with a basic preparation on the mechanism of action and on the process of discovery and development of drugs
- Prerequisites
- Students who enter this course should have knowledge of organic chemistry and biochemistry.
- Teaching methods
- Lectures on all subjects of the course: use of slides that will be delivered to students in electronic format a few days after each lesson through Unistudium
- Other information
- lectures at the classrooms of the Department of chemistry, biology, and biotechnology
- Learning verification modality
- The final exam includes an oral examination, which consists of an interview about the topics covered during the course and mentioned in the program. The examination is designed to verify the knowledge level and understanding capability acquired by the student on the basic aspects related to the medicinal chemistry and the process of drug discovery and development. The oral exam will also assess the student communication skills. The duration of the test varies depending on the performance of the test itself (average duration of about 30 min ).
- Extended program
- Definitions drug and medicine. Structurally specific drugs. Pharmacodynamics. Intermolecular drug-target interactions. Drug targets: structure and function of proteins (receptors, enzymes, ion channels, ion pumps and transport proteins) and nucleic acids. Enzymes and drugs: reversible, irreversible, competitive, incompetitive, non-competitive and allosteric enzyme inhibitors. Receptors and drugs: agonists (pure or partial), antagonists (competitive, non-competitive, allosteric and irreversible) and inverse agonists. Receptor theories. Concepts of affinity, intrinsic activity, potency and efficacy. Nucleic acids and drugs: intercalating agents, alkylating agents and chain terminators. Non-specific drugs. The process of drug discovery and development. Discovery -> hit compound; Design-> lead compound; Development -> dru