Unit SYSTEMIC PATHOLOGY V

Course
Medicine and surgery
Study-unit Code
GP004561
Location
PERUGIA
Curriculum
In all curricula
Teacher
Roberto Gerli
CFU
12
Course Regulation
Coorte 2019
Offered
2022/23
Type of study-unit
Obbligatorio (Required)
Type of learning activities
Attività formativa integrata

BLOOD DISEASES - MOD. 1

Code GP004621
Location PERUGIA
CFU 2
Teacher Cristina Mecucci
Learning activities Caratterizzante
Area Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica
Academic discipline MED/15
Type of study-unit Obbligatorio (Required)
Language of instruction Italian
Contents Emathopoiesis; Anemias: classifications; Abnormalities of erythroid shape and size; Iron deficiency; Megaloblastic anemias; Anemias associated to chronic diseases; Hemolysis; Inherited hemolytic diseases; Hemolysis due to external agents; Thalassemias; Aplastic anemias; Paroxystic Nocturnal Hemoglobinuria; Differential diagnosis of anemic syndromes.
Reference texts HARRISON’S PRINCIPLES OF MEDICINE
TURA-ZINZANI
Educational objectives Knowledge of basichemopoiesis;
Ability to evaluate normal and pathologic cell blood counts;
Diagnosis of most important anemic syndromes.
Prerequisites Physiology, Anatomy, Molecular Medicine, General Pathology.
Teaching methods Teaching in class
Learning verification modality Oral exam
Extended program Emathopoiesis; Anemias: classifications; Abnormalities of erythroid shape and size; Iron deficiency; Megaloblastic anemias; Anemias associated to chronic diseases; Hemolysis; Inherited hemolytic diseases; Hemolysis due to external agents; Thalassemias; Aplastic anemias; Paroxystic Nocturnal Hemoglobinuria; Differential diagnosis of anemic syndromes.

BLOOD DISEASES - MOD. 2

Code GP004622
Location PERUGIA
CFU 1
Teacher Maria Paola Martelli
Teachers
  • Maria Paola Martelli
Hours
  • 12.5 ore - Maria Paola Martelli
Learning activities Caratterizzante
Area Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica
Academic discipline MED/15
Type of study-unit Obbligatorio (Required)

DISEASES OF THE IMMUNE SYSTEM

Code GP005656
Location PERUGIA
CFU 2
Teacher Antonio Pierini
Teachers
  • Antonio Pierini
Hours
  • 25 ore - Antonio Pierini
Learning activities Caratterizzante
Area Medicina delle attività motorie e del benessere
Academic discipline MED/09
Type of study-unit Obbligatorio (Required)

MOLECULAR MEDICINE

Code GP004623
Location PERUGIA
CFU 1
Teacher Cristina Mecucci
Teachers
  • Cristina Mecucci
Hours
  • 12.5 ore - Cristina Mecucci
Learning activities Caratterizzante
Area Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica
Academic discipline MED/15
Type of study-unit Obbligatorio (Required)
Language of instruction Italian
Contents Technological approaches for the study of the genome. Leukemic and tumor stem cells, multistep process of oncogenesis, mechanisms of alteration of oncogenes, tumor suppressors, shelter genes and check-point genes. Clonal hematopoiesis and leukemia pathogenesis. Models of pathogenesis of congenital and acquired medullary insufficiencies. Models of pathogenesis of Acute Leukemia. Tyrosinchinase. Pathogenesis models of lymphoproliferative disorders. Myeloma pathogenesis models. Models of pathogenesis of solid tumors (lung, breast, colon).
Reference texts The material will be provided by professor
Teaching methods Frontal lessons
Seminars
Learning verification modality Multiple choice quiz or oral exam
Extended program Technological approaches for the study of the genome. Leukemic and tumor stem cells, multistep process of oncogenesis, mechanisms of alteration of oncogenes, tumor suppressors, shelter genes and check-point genes. Models of pathogenesis of congenital and acquired medullary insufficiencies. Models of pathogenesis of Acute Leukemia. Tyrosinchinase. Pathogenesis models of lymphoproliferative disorders. Myeloma pathogenesis models. Models of pathogenesis of solid tumors (lung, breast, colon).

REUMATHOLOGY

Code GP005657
Location PERUGIA
CFU 2
Teacher Roberto Gerli
Teachers
  • Roberto Gerli
Hours
  • 25 ore - Roberto Gerli
Learning activities Caratterizzante
Area Clinica delle specialità medico-chirurgiche
Academic discipline MED/16
Type of study-unit Obbligatorio (Required)
Language of instruction ITALIAN
Contents Classification, epidemiology and pathogenesis of rheumatic disease. Clinical features of most common acute and chronic osteoarticular disease, inflammatory and not, of extra-articular rheumatism, of systemic autoimmunitary disease and of systemic vasculitides.
Reference texts REUMATOLOGIA per studenti e Medici di a cura di UNIREUMA. IDELSON GNOCCHI IV Ed. 2022.
HARRISON et al. Principles of Internal Medicine XX Ed.
McGraw Hill Ed.
Educational objectives At the end of the Course students are expected to recognize and define the peculiar features of most common chronic articular conditions, both inflammatory and degenerative, extra-articular rheumatic diseases, systemic autoimmune diseases and systemic vasculitis, from an etiologic, pathogenic and, most importantly, clinical point of view. In addition, the students are asked to prove the ability to recognize and interpret the laboratory tests specific for the aforementioned conditions and the most common instrumental procedures employed in rheumatology clinics. The students’ diagnostic approach based on signs and symptoms will also be evaluated.
Prerequisites In order to start Rheumatology lessons, the student should have good knowledge of anatomy and physiopathology and good skill in general phisical examination of the patient.
Teaching methods The Course includes 25 hours with 14 theoretical hours and 11 hours of practical skills and practical training or seminars.
Other information
Learning verification modality The exam includes a multiple choice written test (30 questions with up to 5 possible answers of which only 1 correct). Score: + 1 for correct answer, - 0.25 for wrong answer, 0 points for not done answer. Questions will cover all rheumatology topics and can be afforded with a basic knowledge of such topics.
The test will be performed only if the pandemic risk will allow it.
The oral exam is open to students who passed the first written test (with a score of at least 18/30) and includes wider questions aimed at evaluating theoretical and practical skills as well as deductive processes and communication. The average examination time is 20-25 minutes.
Extended program 1. Definition, classification and epidemiology of rheumatic diseases
2. The musculoskeletal system: anatomic and functional elements
3. Etiopathogenic mechanisms of rheumatic diseases
4. Signs and syntoms of rheumatic diseases
5. Laboratory and imaging diagnosis and synovial fluid analysis
6. Inflammatory joint diseases
a) Rheumatoid arthritis and other related joint diseases
b) Spondyloarthritis
i. Ankylosing Spondylitis
ii. Reactive arthritis
iii. Psoriatic arthritis
iv. Enteropathic arthritis
c. Polymyalgia rheumatica

7. Connective tissue diseases
a) Systemic lupus erythematosus
b) Antiphospholipid syndrome
c) Systemic sclerosis
d)Polymyositis/Dermatomyositis/Inflammatory myopathies/Anti-synthetasis antibody syndrome
e) Sjögren's syndrome
f) Overlap syndromes, included mixed connective tissue disesase
g) Undifferentiated connective tissue diseases (UCTD)

8. Primary systemic vasculitides
a) Large size-arteries: Takayasu arteritis, Horton arteritis
b) Medium-size arteries: polyarteritis nodosa
c) Medium and small-size vessels ANCA-associated (micropolyangioitis, granulomatosis with polyangioitis - Wegener's granulomatosis, with eosinophilic granulomatosis with polyangioitis - Churg-Strauss syndrome)
9. Small-size vessels
a) Behçet's disease
b) cryoglobulinemia
c) IgA vasculitis - Schönlein-Henoch purpura

10. Septic and post-infective arthritis (rheumatic fever)

11. Microcrystal arthropaties (Gout, Calcium pyrophosphate dihydrate and hydroxyapatite deposition disorders)

12. Osteoarthritis

13. Localized and generalized extra-articular rheumatic diseases and fibromyalgia

14. Neurovascular and neurologic syndrome
a) Raynaud 's phenomenon
b) Carpal tunnel syndrome

15. Autoinflammatory disorders
a. Adult Still disease

16. Miscellaneous disorders associated with rheumatologic manifestations
a. Sarcoidosis

PROFESSIONALISING TRAINING IN BLOOD DISEASES

Code GP004624
Location PERUGIA
CFU 1
Teacher Roberto Gerli
Learning activities Altro
Area Tirocini formativi e di orientamento
Academic discipline MED/15
Type of study-unit Obbligatorio (Required)

Cognomi A-L

CFU
1
Teacher
Cristina Mecucci
Teachers
  • Cristina Mecucci
Hours
  • 25 ore - Cristina Mecucci
Language of instruction
Italian
Contents
Clinical activity in the hospital ward: general approach to the patient with blood count changes.
Discussion of normal and abnormal blood counts: anemia and erythrocytosis
leukopenias and leukocytosis
platelet disorders and platelet diseases
pancytopenias
General approach to the patient with lymphadenomegalyGeneral approach to the patient with splenomegaly
Reference texts
Harrison's - Principles of Internal Medicine
Hoffbrand/Moss - Essential Haematology
Bosi, De Stefano, Di Raimondo, La Nasa – Manuale di Malattie del Sangue
Avvisati – Ematologia di Mandelli
Hoffman - Hematology basic principles and practice
Educational objectives
http://www.med.unipg.it/ccl
Prerequisites
Attendance of the Blood Diseases course
Teaching methods
Training in hospital wards and laboratory
Other information
Site:
Reparto/Day Hospital Ematologia - Ospedale Santa Maria della Misericordia-Perugia
Learning verification modality
Discussion of clinical cases. Practical exam n the hospital ward
Extended program
Clinical activity in the hospital ward: general approach to the patient with blood count changes.
Discussion of normal and abnormal blood counts: anemia and erythrocytosis
leukopenias and leukocytosis
platelet disorders and platelet diseases
pancytopenias
General approach to the patient with lymphadenomegalyGeneral approach to the patient with splenomegaly

Cognomi M-Z

CFU
1
Teacher
Maria Paola Martelli
Teachers
  • Maria Paola Martelli
Hours
  • 25 ore - Maria Paola Martelli

PROFESSIONALISING TRAINING IN DISEASES OF THE IMMUNE SYSTEM

Code GP005658
Location PERUGIA
CFU 1
Teacher Roberto Gerli
Learning activities Altro
Area Tirocini formativi e di orientamento
Academic discipline MED/09
Type of study-unit Obbligatorio (Required)

Cognomi A-L

CFU
1
Teacher
Antonio Pierini
Teachers
  • Antonio Pierini
Hours
  • 25 ore - Antonio Pierini

Cognomi M-Z

CFU
1
Teacher
Antonio Pierini
Teachers
  • Antonio Pierini
Hours
  • 25 ore - Antonio Pierini

PROFESSIONALISING TRAINING IN MOLECULAR MEDICINE

Code GP004625
Location PERUGIA
CFU 1
Teacher Cristina Mecucci
Learning activities Altro
Area Tirocini formativi e di orientamento
Academic discipline MED/15
Type of study-unit Obbligatorio (Required)

Cognomi A-L

CFU
1
Teacher
Cristina Mecucci
Teachers
  • Cristina Mecucci
Hours
  • 25 ore - Cristina Mecucci
Language of instruction
Italian
Contents
Technological approaches to genome surveys. Protocols and their applications.
Educational objectives
Ability to address diagnostic investigations and optimize procedures.
Prerequisites
Knowledge of the genetic basis of tumors.
Teaching methods
Tutor system in working groups.
Learning verification modality
During the exam
Extended program
Conventional cytogenetics. FISH, PCR, sequencing. Telomeres, Chromosomal instability test. Test on paraffin sections. Nucleic acids, separation. Microarrays.

Cognomi M-Z

CFU
1
Teacher
Cristina Mecucci
Teachers
  • Cristina Mecucci
Hours
  • 25 ore - Cristina Mecucci
Language of instruction
Italian
Contents
Technological approaches to genome surveys. Protocols and their applications.
Educational objectives
Ability to address diagnostic investigations and optimize procedures.
Prerequisites
Knowledge of the genetic basis of tumors.
Teaching methods
Tutor system in working groups.
Learning verification modality
during the exam
Extended program
Conventional cytogenetics. FISH, PCR, sequencing. Telomeres, Chromosomal instability test. Test on paraffin sections. Nucleic acids, separation. Microarrays.

PROFESSIONALISING TRAINING IN REUMATHOLOGY

Code GP005659
Location PERUGIA
CFU 1
Teacher Roberto Gerli
Learning activities Altro
Area Tirocini formativi e di orientamento
Academic discipline MED/16
Type of study-unit Obbligatorio (Required)

Cognomi A-L

CFU
1
Teacher
Roberto Gerli
Teachers
  • Roberto Gerli
Hours
  • 25 ore - Roberto Gerli
Language of instruction
Italian
Contents
Clinical activity with Rheumatologist, included clinical history, physical examination, diagnosis and therapeutic intervention; infusion of biotechnological agents; instrumental diagnosis by ultrasound evaluation of muscle-skeletal areas and ultrasound-driven interventions for joints, tendons, ...; diagnosis of microcirculation disorders by videocapillaroscopic examination; evaluations of foot and posture disorders.
Reference texts
REUMATOLOGIA per studenti e Medici a cura di UNIREUMA. IDELSON GNOCCHI IV Ed. 2022.
HARRISON et al. Principles of Internal Medicine XX Ed.
McGraw Hill Ed.
Educational objectives
Results based on check of the acquired ability, behavior and interaction degree of the student.
Prerequisites
For the purpose of learning, the student should have good knowledge of anatomy and physiopathology and good skill in general phisical examination of the patient.
Teaching methods
Partecipation to the above described activities
Learning verification modality
For the professionalizing intership, there is no a specific exam, but this included in the final oral exam.
Extended program
1. Definition, classification and epidemiology of rheumatic diseases
2. The musculoskeletal system: anatomic and functional elements
3. Etiopathogenic mechanisms of rheumatic diseases
4. Signs and syntoms of rheumatic diseases
5. Laboratory and imaging diagnosis and synovial fluid analysis
6. Inflammatory joint diseases
a) Rheumatoid arthritis and other related joint diseases
b) Spondyloarthritis
i. Ankylosing Spondylitis
ii. Reactive arthritis
iii. Psoriatic arthritis
iv. Enteropathic arthritis
c. Polymyalgia rheumatica

7. Connective tissue diseases
a) Systemic lupus erythematosus
b) Antiphospholipid syndrome
c) Systemic sclerosis
d)Polymyositis/Dermatomyositis/Inflammatory myopathies/Anti-synthetasis antibody syndrome
e) Sjögren's syndrome
f) Overlap syndromes, included mixed connective tissue disesase
g) Undifferentiated connective tissue diseases (UCTD)

8. Primary systemic vasculitides
a) Large size-arteries: Takayasu arteritis, Horton arteritis
b) Medium-size arteries: polyarteritis nodosa
c) Medium and small-size vessels ANCA-associated (micropolyangioitis, granulomatosis with polyangioitis - Wegener's granulomatosis, with eosinophilic granulomatosis with polyangioitis - Churg-Strauss syndrome)
9. Small-size vessels
a) Behçet's disease
b) cryoglobulinemia
c) IgA vasculitis - Schönlein-Henoch purpura

10. Septic and post-infective arthritis (rheumatic fever)

11. Microcrystal arthropaties (Gout, Calcium pyrophosphate dihydrate and hydroxyapatite deposition disorders)

12. Osteoarthritis

13. Localized and generalized extra-articular rheumatic diseases and fibromyalgia

14. Neurovascular and neurologic syndrome
a) Raynaud 's phenomenon
b) Carpal tunnel syndrome

15. Autoinflammatory disorders
a. Adult Still disease

16. Miscellaneous disorders associated with rheumatologic manifestations
a. Sarcoidosis

Cognomi M-Z

CFU
1
Teacher
Carlo Perricone
Teachers
  • Carlo Perricone
Hours
  • 25 ore - Carlo Perricone
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