Unit CHEMISTRY AND BIOCHEMISTRY I

BIOCHEMISTRY I - MOD. 1

Code	GP004762
CFU	3
Teacher	Davide Chiasserini
Teachers	Davide Chiasserini
Hours	37.5 ore - Davide Chiasserini
Learning activities	Base
Area	Struttura, funzione e metabolismo delle molecole d'interesse biologico
Academic discipline	BIO/10
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Structural biochemistry: carbohydrates, lipids, nucleotides, nucleic acids, amino acids, proteins. Hemoglobin and myoglobin
Reference texts	Biochimica Medica Siliprandi, Tettamanti Piccin I principi di Biochimica del Lehninger - Nelson, Cox, Zanichelli Harper's Biochimica Illustrata - Murray et al - EMSI Biochimica Umana Salvatore Idelson Gnocchi Biochimica Devlin EdiSES Biochimica Berg, Tymoczko, Stryer Zanichelli
Educational objectives	The main competence will be to have a general knowledge necessary to address the classes of Module 2.
Prerequisites	The student must have acquired basic knowledge of the main topics of General Chemistry and Organic Chemistry
Teaching methods	The course is organized in theoretical classroom lessons
Other information	The attendance is compulsory at least for 75% of classes. Terni School of Medicine – Educational and Scientific Center
Learning verification modality	The final exam consists of a written test with multiple choice questions and an oral exam
Extended program	Structure and chemical properties of biological compounds. Carbohydrates: monosaccharides and disaccharides. homopolisaccharides (cellulose, starch and glycogen). heteropolysaccharides (hyaluronic acid, chondroitin sulfate, dermatan sulfate, keratan, heparin). Lipids: fatty acids, acylglycerols, phospholipids. Cholesterol. Nucleosides, nucleotides and nucleic acids. Proteins: Structure and properties of amino acids. Peptide bond. Structural organization of proteins. Denaturation. Outline of analytical techniques for the separation and balance of proteins. Globular proteins. Fibrous proteins (collagen, keratin and elastin). Physico-chemical properties of proteins. Immunoglobulins and conjugated proteins. Myoglobin (structure and function). Hemoglobin (structure and function). Molecular mechanism of oxygen transport. Factors that alter the affinity of hemoglobin for oxygen. Hemoglobin as buffer. Hemoglobin role in the transport of carbon dioxide. Types of hemoglobin and glycated hemoglobin, mutation of hemoglobin.

BIOCHEMISTRY I - MOD. 2

Code	GP004764
CFU	3
Teacher	Ilaria Bellezza
Teachers	Ilaria Bellezza
Hours	37.5 ore - Ilaria Bellezza
Learning activities	Base
Area	Struttura, funzione e metabolismo delle molecole d'interesse biologico
Academic discipline	BIO/10
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	The Module 2 program covers the following topics: Enzymes. Coenzyme structure and mechanism of action. Biological membranes. Signal transduction. Catabolism and Anabolism. Bioenergetics. High-energy bonds. ATP. Respiratory chain and oxidative phosphorylation
Reference texts	I principi di Biochimica del Lehninger - Nelson, Cox, Zanichelli Harper's Biochimica Illustrata - Murray et al - EMSI Biochimica Umana Salvatore Idelson Gnocchi Biochimica Devlin EdiSES Biochimica Berg, Tymoczko, Stryer Zanichelli Biochimica Medica Siliprandi, Tettamanti Piccin
Educational objectives	At the end of the course the student should be in possession of the main knowledge related to Structural Biochemistry, Catabolism and Anabolism and Energy Biochemistry
Prerequisites	The student must have acquired basic knowledge of the main topics of General Chemistry and Organic Chemistry and Structural Biochemistry
Teaching methods	The course is organized in classroom theoretical lessons
Other information	The attendance is compulsory at least to 75% of classes. Terni School of Medicine – Educational and Scientific Center
Learning verification modality	The final exam consists of a written test with multiple choice questions and an oral exam
Extended program	Enzymes: enzymatic catalysis. Active site. Specificity. Nature of enzymes and their classification. Constitutive and inducible enzymes. Kinetics of enzymatic reactions. Michaelis-Menten constant and its significance. Factors influencing enzyme activity. Enzyme inhibition. Mechanisms of enzyme inhibition. Regulation of enzyme activity. Hints of clinical enzymology. Vitamins and coenzymes: dietary sources of vitamins. Water-soluble vitamins (C, biotin, niacin, thiamin, pantothenate, riboflavin, pyridoxine, folate, B12) and their coenzyme action. Notes on fat-soluble vitamins (A, E, K, D). General aspects of metabolism: Catabolism and Anabolism. Bioenergetics: general principles of chemical thermodynamics. Oxidation-reduction potential. High energy hydrolysis bonds. ATP: structure and role in energy transfer. Phosphorylation at substrate level. Respiratory chain and oxidative phosphorylation. Respiratory chain inhibitors and uncoupling agents.

CHEMISTRY - MOD. 1

Code	GP004761
CFU	3
Teacher	Veronica Ceccarelli
Teachers	Veronica Ceccarelli
Hours	37.5 ore - Veronica Ceccarelli
Learning activities	Base
Area	Struttura, funzione e metabolismo delle molecole d'interesse biologico
Academic discipline	BIO/10
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	The electronic structure and the properties of atoms: the quantum numbers, the atomic orbitals, the electronic configurations of the elementsPeriodic table of the elements and the properties of elements: ionization potential, electron affinity and electronegativityCovalent molecules: the combination of s orbitals, the combination of p orbitals, the formation of diatomic molecules; poliatomic molecules.Chemical bonds: covalent bonds, ionic bonds, idrogen bond, ibridization, Inorganic moleculesSolid state, liquid state and vapor stateSolution chemistryAcids and bases and chemical balancepH measurements of different solutionsPrinciples of thermodynamics, chemical kinetics and oxidation status
Reference texts	Chimica e Propedeutica Biochimica - Luciano Binaglia e Bruno Giardina
Educational objectives	The main competence will be to have a general knowledge of inorganic chemistry
Prerequisites	In order to be able to understand and apply the majority of the contents described within the course, the student must have acquired basic knowledge of chemistry and mathematics studied for access to the Faculty of Medicine.
Teaching methods	The course is organized with face to face lessons on all subjects of the course using slide projections.Students are stimulated to interact with the teacher during the lectures.Hours available to the students to be established during the course for clarification and insights.During the course you will have an ongoing learning test
Other information	The attendance is compulsory at least 75% of lessonsTerni - School of Medicine - Educational and Scientific Center
Learning verification modality	The final exam consists of a pratical test and an oral exam
Extended program	The electronic structure and the properties of atoms: the quantum numbers, the atomic orbitals, the electronic configurations of the elementsPeriodic table of the elements and the properties of elements: ionization potential, electron affinity and electronegativityCovalent molecules: the combination of s orbitals, the combination of p orbitals, the formation of diatomic molecules; poliatomic molecules.Chemical bonds: covalent bonds, ionic bonds, idrogen bond, ibridization, Inorganic moleculesSolid state, liquid state and vapor stateSolution chemistryAcids and bases and chemical balancepH measurements of different solutionsPrinciples of thermodynamics, chemical kinetics and oxidation status

CHEMISTRY - MOD. 2

Code	GP004763
CFU	2
Teacher	Veronica Ceccarelli
Teachers	Veronica Ceccarelli
Hours	25 ore - Veronica Ceccarelli
Learning activities	Affine/integrativa
Area	Attività formative affini o integrative
Academic discipline	BIO/10
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Hydrocarbons: alkanes, alkenes, alkines and their characteristic reactionsaromatic hydrocarbons and their characteristic reactionsstereoisomery and enantiomersalcohols, phenols and their characteristic reactionsalkyl halidesaldehydes and ketones and reactions aliphatic and aromatic amines carboxylic acids and their reactions derivatives of carboxylic acidsaromatic heterocycles
Reference texts	Chimica e Propedeutica Biochimica - Luciano Binaglia e Bruno Giardina
Educational objectives	The main competence will be to have a general knowledge of organic chemistry in order to approach the study of biochemistry
Prerequisites	In order to be able to understand and apply the majority of the contents described within the course, the student must have acquired basic knowledge of Inorganic chemistry
Teaching methods	The course is organized with face to face lessons on all subjects of the course using slide projections.Students are stimulated to interact with the teacher during the lectures.Hours available to the students to be established during the course for clarification and insights.During the course you will have an ongoing learning test
Other information	The attendance is compulsory at least 75% of lessonsTerni - School of Medicine - Educational and Scientific Center
Learning verification modality	The final exam consists of a pratical test and an oral exam
Extended program	Hydrocarbons: alkanes, alkenes, alkines and their characteristic reactionsaromatic hydrocarbons and their characteristic reactionsstereoisomery and enantiomersalcohols, phenols and their characteristic reactionsalkyl halidesaldehydes and ketones and reactions aliphatic and aromatic amines carboxylic acids and their reactions derivatives of carboxylic acidsaromatic heterocycles