| Code |
GP000527 |
| CFU |
6 |
| Teacher |
Cinzia Antognelli |
| Teachers |
|
| Hours |
- 42 ore - Cinzia Antognelli
|
| Learning activities |
Base |
| Area |
Discipline biologiche e morfologiche |
| Sector |
BIOS-10/A |
| Type of study-unit |
Opzionale (Optional) |
| Language of instruction |
Italian |
| Contents |
Characteristics of living organisms. Biological macromolecules. Prokaryotic and eukaryotic cells. Viruses (general overview). Information flow in living matter (gene expression) and its regulation. The cell cycle and its control. Mutations. Reproduction of multicellular organisms: meiosis and gametogenesis. Introduction to tissue biology. |
| Reference texts |
McGraw-Hill; P. Bonaldo, S. Suga, R. Pierantoni, P. Riva, M.G. Romanelli – Biology and Genetics – EdiSES. R. Roberti, G. Alunni Bistocchi, C. Antognelli, V.N. Talesa – Biochemistry and Biology for Health Professions. |
| Educational objectives |
To provide the foundational knowledge necessary to approach the study of more complex basic disciplines (Anatomy, Physiology, Microbiology, and Pharmacology). The main competencies acquired will concern the integrated study of the cell and living organisms, with particular focus on: molecular mechanisms involved in the biogenesis of organelles and cellular structures, interactions between cells and between cells and the extracellular environment, duplication, transmission and expression of genetic information, and cellular proliferation. |
| Prerequisites |
To provide students with the foundational knowledge needed to successfully engage with more advanced basic sciences such as Anatomy, Physiology, Microbiology, and Pharmacology. The primary learning outcomes will focus on the integrated study of cells and living organisms, with particular emphasis on: the molecular mechanisms involved in the biogenesis of organelles and cellular structures, cell-to-cell and cell–extracellular environment interactions, the duplication, transmission, and expression of genetic information, and cellular proliferation. |
| Teaching methods |
Lectures supported by PowerPoint presentations featuring images and animations (including video clips). Attendance is strongly recommended in order to facilitate learning and ensure effective and meaningful student training. |
| Other information |
Instructor’s Office: Department of Medicine and Surgery – Building B, 4th floor – P.le L. Severi 1 – Sant'Andrea delle Fratte – Perugia. Student Office Hours: The instructor is always available to meet with students upon request via email (cinzia.antognelli@unipg.it). |
| Learning verification modality |
The exam consists of a final written test (multiple-choice questions requiring reasoning). The test includes 60 questions, each with 5 answer options, only one of which is correct. The duration of the exam is 60 minutes. One point is awarded for each correct answer; incorrect or unanswered questions receive 0 points. The exam as a whole is designed to assess the student’s knowledge and understanding of the course content. Students with Specific Learning Disorders (SLD) and/or disabilities are entitled to the compensatory and/or dispensatory measures provided by current legislation and the University of Perugia regulations. For information about support services for students with disabilities and/or DSA, visit the page http://www.unipg.it/disabilita-e-dsa. |
| Extended program |
Characteristics of living organisms. Biological macromolecules: proteins, lipids, and carbohydrates (overview). Cellular organization models: prokaryotes and eukaryotes. Viruses: general overview. Animal eukaryotic cell. Plasma membrane: structure and functions, with particular focus on transport mechanisms and cell communication; cytoplasm; ribosomes; smooth and rough endoplasmic reticulum; Golgi apparatus; lysosomes; peroxisomes; mitochondria and the energy problem; cytoskeleton (overview); nucleus and nucleolus. DNA and RNA: structure and function. Chromatin organization, chromosomes. Eukaryotic gene. Gene expression: transcription, processing of primary transcripts, genetic code, translation. Regulation of gene expression: overview. Cell cycle: interphase, DNA replication, mitosis. Cell cycle regulation: checkpoints and CdK-cyclin complexes. Proto-oncogenes and tumor suppressor genes. Gene mutations (point mutations: missense, silent, nonsense, neutral), genomic mutations (aneuploidy and polyploidy), and chromosomal mutations (deletion, duplication, inversion, translocation). Normal and pathological human karyotype. X chromosome inactivation (heterochromatinization). Reproduction of multicellular organisms; meiosis and its significance, male and female gametogenesis. Introduction to tissue biology. |
| Obiettivi Agenda 2030 per lo sviluppo sostenibile |
3. Health and Well-being – 4. Quality Education |
