Unit PROPAEDEUTICS

ANESTHESIOLOGY

Code	50A00182
CFU	1
Teacher	Laura Marchesini
Teachers	Laura Marchesini
Hours	12 ore - Laura Marchesini
Learning activities	Caratterizzante
Area	Scienze interdisciplinari cliniche
Academic discipline	MED/41
Type of study-unit	Obbligatorio (Required)

PHARMACOLOGY

Code	50A00187
CFU	2
Teacher	Emira Maria Ayroldi
Teachers	Emira Maria Ayroldi
Hours	24 ore - Emira Maria Ayroldi
Learning activities	Caratterizzante
Area	Scienze medico-chirurgiche
Academic discipline	BIO/14
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Pharmacokinetic: Absorption, Distribution, Elimination, Metabolism Pharmacodynamics: Interaction drug/receptor Radio-drugs Sedative-hypnotic Treatment of pain, inflammation and allergic reactions (NSAIDs, glucocorticoids and antihistamines)
Reference texts	- Mario Furlanut Farmacologia Principi e applicazioni, casa editrice Piccin - SG Cella, AM DI Giulio, A. Gorio, F. Scaglione Farmacologia generale e speciale per le lauree sanitarie , casa editrice Piccin
Educational objectives	After concluding the course, students: 1) should know and understand (To know) the mechanism of action, pharmacokinetics, side effects, toxicological aspects, and contraindications of the drugs contained in the program with a focus on treatment and / or diagnosis with radionuclides. Students will also learn about adverse reactions to contrast agents and their treatment; 2) should apply independently and critically the acquired knowledge to their work (Know-how), and they must be able to supervise, when performing an instrumental examination with contrast medium and/or that requires drug treatment, the physical and mental wellbeing of the patient (Knowing how to be).
Prerequisites	To fully understand the items contained within the programs, students must have a good knowledge of biology, physiology, and anatomy and possess the basics of electrophysiology and pathophysiology of inflammation.
Teaching methods	The lessons will be divided in: 1) General pharmacology, which lays the basis for the study of the mechanism of action of drugs; 2) Special pharmacology, which analyzes the mechanism of action, clinical use and side effects of the most common drugs. Each new lesson will be preceded by a summary of the previous lesson, with the help of students, who are often encouraged to intervene in the course of the lesson, with the aim to achieve maximum understanding and learning of the topic, directly in classroom.
Other information	The frequency is mandatory The lessons will be held at the University Hospital Santa Maria della Misericordia, Building C
Learning verification modality	The exam is an oral test consisting of a discussion lasting about 20 minutes, which will be aimed not only to test knowledge of the programs, but also to judge the student's ability to critical associations, for example, pharmacological effects with the pathophysiology and side effects. The potential to apply the acquired knowledge and presentation skills and reasoning, will compete for the final judgment of the student.
Extended program	GENERAL PHARMACOLOGY - Pharmacokinetic: 1) Absorption: factors that influence the passage of drugs across biological membranes. Routes of drug administration 2) Distribution: factors affecting the distribution of drugs 2) Targeting mechanisms of the radio-drug 3) Characteristics and clinical uses of the main radio drugs used in nuclear medicine, [18F] -FDG (Fluorodeoxyglucose), 131I-sodium iodide, 89Strontium chloride (89Sr), sodium-32P-phosphate (32P), 67Gallium and positive indicators - Adverse drug reactions (ADRs) and drug treatments: 1) Glucocorticoids: mechanism of action and hypothalamus pituitary axis, physiological effects and pharmacological effects, side effects, outline of clinical uses 2) Antihistamines: mechanism of action, histamine and histamine receptors, side effects, notes on clinical uses - Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): 3) Metabolism: phase I and II reactions. Induction and inhibition of drug metabolism. Factors affecting the biotransformation 4) Excretion of drugs: renal and biliary excretion. Other routes of excretion of drugs 5) Bioavailability and first pass effect. Volume of distribution, clearance, half-life - Pharmacodynamic: 1) Receptors: definition and characteristics, specificity, signal transduction, saturable and reversible binding 2) Quantitative aspects of drug-receptor interactions: affinity, efficacy and intrinsic activity 3) Agonists and antagonists (competitive and non-competitive) 4) Classification of receptors and mechanism of action SPECIAL PHARMACOLOGY - Radionuclide therapy: 1) Radioactive isotope, radio-drug, radionuclide production, preparation of radio-drug

ONCOLOGY

Code	A000442
CFU	1
Teacher	Mario Mandala'
Teachers	Mario Mandala'
Hours	12 ore - Mario Mandala'
Learning activities	Caratterizzante
Area	Scienze interdisciplinari cliniche
Academic discipline	MED/06
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Tumors definition Tumors classification Tumors grading Tumors staging Diagnosis of tumors (lab and imaging tests, tumor markers) Tumors epidemiology (incidence, prevalence and mortality) Primary prevention of tumors Secondary prevention of tumors (early diagnosis) Oncological patients management (multisciplinary oncological groups, regional oncological network) Principles of medical therapy in oncology Toxicity of oncological treatments Supportive and palliative therapy in oncology Oncological emergencies Update on the prophylaxis and therapy of some symptoms and adverse events of antineoplastic agents. Diagnostic and therapeutic approach to some tumors: breast, lung, prostate and colo-rectal cancers Myths and misconceptions on cancer
Reference texts	Slides shared with students AIOM Guidelines
Educational objectives	Basic knowledge of general pathology aspects, of tumors diagnostics and therapies.
Prerequisites	Notions on the tumors characteristics, on the modality of prevention and early diagnosis, on the diagnostic tests and on therapies (from surgery to radiotherapy, from hormonotherapy to target therapies and to immunotherapy) including supportive therapies and palliative care with the objective to have a wide panorama of the medical oncology.
Teaching methods	Frontal interactive lessons
Other information	Interactive clinical cases
Learning verification modality	HOW WILL THE EXAM BE CARRIED OUT: Written answers to multiple choice questions There will be 30 questions, 1 point for each question. For each question there will be only one correct answer. The questions will focus on the program carried out METHOD OF ALLOCATION OF THE FINAL SCORE: arithmetic mean of the scores obtained in the individual disciplines (This calculation is in charge of coordinator of the integrative course).
Extended program	Cancer definition (difference between normal and neoplastic cells, cancer metastases, tumors classification, grades and stages of tumors); epidemiology and risk factors; primary prevention in the general population and in patients at risk; secondary prevention: screening tests; tumor diagnosis and TMN stadiation; principles of locoregional therapy (surgery and radiotherapy); general concepts of systemic anti-tumor therapy with reference to chemotherapy, hormone therapy, molecular target therapy, immunotherapy. Main organ toxicities of systemic therapies and their management with particular reference to bone marrow toxicity, gastrointestinal toxicity, skin toxicity; cardiotoxicity, pulmonary and neurological toxicity, autoimmune toxicity during immunotherapy. Oncological emergencies (superior vena cava syndrome, spinal cord compression, brain metastases, hypercalcemia, hyponatremia), infectious emergencies and septic shock, metabolic syndromes. Treatment of neoplastic pain in oncological patients.
Obiettivi Agenda 2030 per lo sviluppo sostenibile	Promoting health, reducing inequalities

PATIENT HANDLING AND MOVEMENT

Code	A000443
CFU	1
Teacher	Luca Collebrusco
Teachers	Luca Collebrusco
Hours	12 ore - Luca Collebrusco
Learning activities	Caratterizzante
Area	Scienze della prevenzione e dei servizi sanitari
Academic discipline	MED/48
Type of study-unit	Obbligatorio (Required)

PSYCHOLOGY

Code	A000444
CFU	1
Teacher	Claudia Mazzeschi
Teachers	Claudia Mazzeschi
Hours	12 ore - Claudia Mazzeschi
Learning activities	Affine/integrativa
Area	Attività formative affini o integrative
Academic discipline	M-PSI/07
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian.
Contents	The course aims to introduce the student to the knowledge of the biopsychosocial model for defining health, the medical approach and the psychological approach, the functioning of personality and defence mechanisms, emotions, and the human reaction in relation to diagnosis.
Reference texts	- Munno, D. (2008). Psicologia clinica per medici. Chapters: 1, 3, 4 - Articles covered in the lecture Further reading: - Lingiardi, V. (2018). Diagnosi e destino. Giulio Einaudi Editore. - Pervin, A.l., John, O. (1997). La scienza della personalità. Raffaello Cortina Editore. Chap. 1, 3
Educational objectives	The main objective of the course is to provide students with knowledge and skills concerning human mechanisms and reactions when faced with a disease diagnosis.
Prerequisites	To understand the planning and evaluation of psychological interventions, it is advisable to have a basic knowledge of the biomedical model of health. Furthermore, it is advisable to be able to read and comprehend scientific articles in English.
Teaching methods	The lectures will take place as face-to-face lecture for most of the arguments. Student’s active interaction is welcome.
Other information	The student can check the course material and any announcements/notices from the Professor on UniStudium during the course.
Learning verification modality	Written and/or oral examination. For written examination: 15 MULTIPLE-CHOICE QUESTIONS ON THE SYLLABUS. EVALUATION: 2 = CORRECT ANSWER; 0 = WRONG ANSWER OR NOT GIVEN If the student intends to take the examination a year before the year scheduled in the study plan, it is recommended that he/she attend the cycle of lectures and take the examination in the first useful call after the lectures have ended, thus respecting the semester in which the course is scheduled.
Obiettivi Agenda 2030 per lo sviluppo sostenibile	Goal 3. Ensure healthy lives and promote well-being for all at all ages