Unit BIOMEDICAL SCIENCES
- Course
- Midwifery
- Study-unit Code
- A000966
- Curriculum
- In all curricula
- Teacher
- Silvia Bozza
- CFU
- 5
- Course Regulation
- Coorte 2022
- Offered
- 2023/24
- Type of study-unit
- Obbligatorio (Required)
- Type of learning activities
- Attività formativa integrata
MEDICAL GENETICS
Code | GP003922 |
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CFU | 1 |
Teacher | Antonio Orlacchio |
Teachers |
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Hours |
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Learning activities | Base |
Area | Scienze biomediche |
Academic discipline | MED/03 |
Type of study-unit | Obbligatorio (Required) |
Language of instruction | Italian |
Contents | Structural and functional organization of the human genome. DNA mutations and their correlation with: i) mode of inheritance; ii) diagnostic procedures; iii) pathogenetic role; iv) clinical manifestations. Classification of genetic diseases (Mendelian inheritance, multifactorial, chromosomal, and mitochondrial). Atypical inheritance. Taking care of the patient and/or the family with hereditary disease: "genetic counseling." General and specific criteria with reference to the different clinical conditions. Genetic counseling aimed to prenatal diagnosis, before and after genetic testing. Preimplantation diagnosis. The causal treatment of genetic diseases. |
Reference texts | Genetica umana e medica Authors: Neri Giovanni, Genuardi Maurizio Publisher: Edra Masson (4th Edition - 2017) Genetica & Genomica nelle scienze mediche Authors: Strachan Tom, Read Andrew P. Publisher: UTET (3rd Edition - 2021) Genetica Medica Authors: Dallapiccola Bruno, Novelli Giuseppe Publisher: Edizioni Scientifiche Falco (4th Edition - 2022) |
Educational objectives | To know the contents and methods of communication of the genetic counseling. To recognize the clinical manifestations of the major classes of genetic diseases with prenatal and post-natal care. To be able to correlate the clinical phenotype with the corresponding biological causal factors (phenotype-genotype correlation) with the following purposes: 1) setting of an analytical path, 2) identification of mutations responsible for the disease (etiologic diagnosis) and 3) interpretation of the results for diagnostic purposes, assessment of prognosis, and clinical follow-up, 4) risk assessment procreative and relatives of the proband (risk of recurrence), based on the model of inheritance; 5) planning of interventions aimed to prevention (prenatal diagnosis). |
Prerequisites | The student must have argued with success the examination of "Physiology, Biochemistry, and Applied Biology". Furthermore, must have acquired a good research methodology. |
Teaching methods | The teaching will be carried out with face-to-face lessons that will cover the entire program of study. |
Other information | Oral explanations will be coadiuvated by PowerPoint presentations. Summaries of these presentations, other additional didactic materials and possible updatings and communications, will be made available to students, in pdf format for download, through a dedicated homepage of the University of Perugia. During the whole Academic Year, students may request by e-mail personal reception to the teacher. |
Learning verification modality | The examination will consist in an oral test on the topics listed in the syllabus. |
Extended program | - Introduction to the course - Organization and changes in the human genome - Methods for molecular analysis of nucleic acids - Human Chromosomes and mechanisms of formation of chromosomal abnormalities - Cytogenetics techniques - Mendelian inheritance and fundamental principles of medical genetics - Atypical mechanisms of inheritance - Genetic counseling - Chromosome number abnormalities - Chromosomal structural abnormalities - Abnormalities of the sex chromosomes - Monogenic diseases - Multifactorial diseases - Disorders related to CFTR gene - Congenital defects |
Obiettivi Agenda 2030 per lo sviluppo sostenibile | Quality education |
MICROBIOLOGY AND CLINICAL MICROBIOLOGY
Code | 50252602 |
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CFU | 2 |
Teacher | Silvia Bozza |
Teachers |
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Hours |
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Learning activities | Base |
Area | Scienze biomediche |
Academic discipline | MED/07 |
Type of study-unit | Obbligatorio (Required) |
Language of instruction | Italian |
Contents | General bacteriology General Vitology General mycology General parasitology Pathogenesis microbiome Special bacteriology in obstetric-gynecological infections Special Virology in obstetric-gynecological infections Special Mycology in obstetric-gynecological infections Special Protozoology in obstetric-gynecological infections Clinical Microbiology The vaginal swab, the cervical swab, the rectal swab, the urethral swab. |
Reference texts | P.R. Murray, K.S. Rosenthal, M. A. Pfaller. MICROBIOLOGIA MEDICA - nona edizione. Edra Masson Sherris Microbiologia Medica, 2012, EMSI Editore Lessons' slides |
Educational objectives | The purpose of this course is to provide students with the contents and skills necessary to understand the causes, pathogenesis, and prevention actions of the main diseases in particular regard of obstetric-gynecological. In this regard, the fundamental aspects of infections, the diagnostic procedures, the prophylaxis, and the therapy of the infections will be discussed. |
Prerequisites | Knowledge of Biology, Immunology and Anatomy. |
Teaching methods | The course will be held through lectures |
Other information | Compulsory attendance |
Learning verification modality | The oral examination will last at least 20 minutes, divided into 2 questions relating to the topics covered in class. A third question on the minimum indispensable knowledge can be made in the case of an unsatisfactory answer to the 2 questions. FINAL GRADE: average of the grades of the individual teachings. |
Extended program | The world of microorganisms The basic structure of the bacterial cell (cell wall of Gram + and Gram bacteria, Cytoplasm, Nucleus, Cytoplasmic membrane, Mesosomes) The optional structures of the bacterial cell (pili, flagella, capsule, spore), Bacterial metabolism Bacterial genetics (genetic exchange between bacteria, Conjugation, Transduction, Transformation), Plasmids, Transposons, Insertion sequences Transmission paths of microorganisms Pathogenesis and virulence factors of bacteria (Capsules, Adhesins, Toxins, Esoenzymes). General Virology: Structure of viruses Viral replication Viral pathogenesis General Mycology The Miceti structure The pathogenesis of mycetes General protozoology The structure of protozoa Pathogenesis, concepts of parasitism. The Communal Microbial Flora Vaccines Sera Serological tests (Antibody titre, seroconversion) Disinfection and sterilization Special bacteriology in obstetric-gynecological infections: Streptococcus agalactiae, Neisseria gonorrhoeae, Treponema pallidum, Mycoplasma spp. Ureaplasma spp., Chlamydia trachomatis, Listeria monocytogenes. The vaginal microbiome Special Virology in obstetric-gynecological infections: Parvovirus B19, Hepatitis A virus, B, C, D, E, HPV, Herpesvirus, HIV, Togavirus Special Mycology in obstetric-gynecological infections: Candida albicans Special Protozoology in obstetric-gynecological infections: Trichomonas vaginalis, Toxoplasma gondii Sexually transmitted diseases (MST) Obstetric-gynecological infections:Vaginosis, Vaginitis, Vulvovaginitis, Urretitis, Cervicitis, Salpingitis Clinical Microbiology. The vaginal swab, the cervical swab, the rectal swab, the urethral swab |
GENERAL PATHOLOGY
Code | 50562602 |
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CFU | 2 |
Teacher | Giuseppe Servillo |
Teachers |
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Hours |
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Learning activities | Base |
Area | Scienze biomediche |
Academic discipline | MED/04 |
Type of study-unit | Obbligatorio (Required) |
Language of instruction | Italian |
Contents | - Molecular Pathology - Major genetic diseases - Diseases to environmental causes - Cellular pathology and cell death - Inflammation - Molecular Oncology - Elements of the pathophysiology of organs and apparatuses |
Reference texts | 1. G.M. Pontieri. Patologia e fisiopatologia generale. Per i corsi di laurea in professioni sanitarie. Piccin 2.Spector. Introduzione alla Patologia Generale, Casa editrice Ambrosiana 3. Pontieri. Patologia generale, Piccin 4. Robbins. Le basi patologiche delle malattie, Elsevier |
Educational objectives | - Molecular Pathology - Major genetic diseases - Diseases to environmental causes - Cellular pathology and cell death - Inflammation - Molecular Oncology - Elements of the pathophysiology of organs and apparatuses mainly related to pregnancy. |
Prerequisites | In order to understand and know how to apply most of the knowledge provided by the teaching it is important to have successfully defended the exams of the first year of the degree course. The student must in fact possess the knowledge of the processes that take place within the cell and within and between the various organs and body systems. Students must know the basics of the profession of midwifery. |
Teaching methods | Frontal lectures. The lectures are on the whole program of the course of study, but are also on specialized topics that emerge from the specific needs of learners, all in a view of a highly vocational intent of the course. Each lesson has a duration of two hours on a specific topic, but relating it to others already exposed, to allow the student to have an integrated vision. |
Other information | Compulsory attendance |
Learning verification modality | According to the demands of the students, even though it is integrated, the exam includes an oral testing the pipeline for the form of Microbiology and Clinical Microbiology and a final examination of General Pathology with a final score derived from the mediation between the votes obtained in the two modules. The oral tests consist of discussions lasting 30 minutes on average on 3 questions, designed to ascertain: - Level of knowledge of the topics - Ability of understanding, connection and integration of informations -Capacity and exhibition of language |
Extended program | 1. Introduction to the concept of health and disease. The field of interest of the general pathology. 2. The communication between cells. The structural basis of communication. The cellular signaling: endocrine, autocrine and paracrine. Interactions between cells and matrix. Pathology of cellular signaling. 3. The cell damage and adaptive mechanisms. Causes and mechanisms of intrinsic cellular damage (genetic diseases. Mendelian diseases. Polygenic diseases. Diseases cytogenetics. The molecular diagnosis of genetic diseases and genomics-based) and environmental diseases (Environmental Pollution. Damage to chemical and physical agents. Nutritional diseases. The diseases infectious. Teratogenicity). Morphological and molecular aspects of cell damage. The answer to the subcellular damage. The cellular adaptation. Hypertrophy and ipotrofie. Cell death. 4. Elements of immunology and immunopathology. The acute and chronic inflammation. Acute inflammation. Vascular changes. Cellular events: the exudation and leukocyte phagocytosis. The chemical mediators of inflammation. Chronic inflammation: definition and causes. The role of the lymphatic system and lymphoid tissue in inflammatory processes. Systemic manifestations of the inflammatory process. 5. The healing process. The cell cycle and the control of cell proliferation. The repair to scar. Mechanisms of wound healing. Pathology of healing process. Integration of inflammatory and reparative processes. 6. The tumor and cell transformation. Definitions and nomenclature. Characteristics of benign and malignant neoplasms. Malignancies. Cancer epidemiology. Carcinogenesis and the molecular basis of cancer. Biology of the neoplastic proliferation. Etiology of cancer: carcinogens. 7. Essentials of pathophysiology of the blood, the endocrine system, the cardiovascular system, liver, respiratory system, urogenital system. |
Obiettivi Agenda 2030 per lo sviluppo sostenibile |