Unit INFECTIOUS DISEASES PREVENTIVE MEDICINE

EPIDEMIOLOGY

Code	85008002
CFU	2
Teacher	Fabrizio Passamonti
Learning activities	Caratterizzante
Area	Discipline delle malattie infettive ed infestive
Academic discipline	VET/05
Type of study-unit	Obbligatorio (Required)

LARGE ANIMAL INFECTIOUS DISEASES

Code	GP005418
CFU	4
Teacher	Fabrizio Passamonti
Teachers	Fabrizio Passamonti
Hours	100 ore - Fabrizio Passamonti
Learning activities	Caratterizzante
Area	Discipline delle malattie infettive ed infestive
Academic discipline	VET/05
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	The course focuses on with the major infectious diseases of domestic and wild animals with particular reference to etiological, epidemiological, diagnostic and prophylactic features. Theoretical lessons: Course introduction (organization and final exam information). Equine Herpetic infections: EHV-1, EHV-4, EHV-3, EHV-2 and EHV-5 (1.5 hours); Equine viral arteritis (1.5 hours), Influenza viruses (1.5 hours), Equine infectious anemia (1.5 hours), Rhodococcus equi infection, Strangles, Contagious Equine Metritis (1.5 hours). Brucellosis (1.5 hours); Tuberculosis (1.5 hours); Paratuberculosis (1.5 hours); Mastitis (1.5 hours); Bovine rhinotracheitis virus, Parainfluenza-3 virus, Viral Respiratory Syncytial virus (1.5 hours); Bovine Viral Diarrhea / Mucosal Disease virus, Border disease (1.5 hours); Enzootic Bovine Leukosis, Visna-Maedi, Caprine Arthritis Encephalitis virus, Sheep Pulmonary Adenomatosis (1.5 hours) Caseous Lymphadenitis (CLA), Contagious Ecthyma (1 hour), Infectious Abortion in ruminants (1.5 hours). Aujeszky's disease/Pseudorabies (1.5 hours), Classical Swine Fever (1.5 hours), Swine Erysipelas (1 hour), Parvovirosis in pigs, Porcine Reproductive and Respiratory Syndrome, Swine Circovirus (1.5 hours) Diseases sustained by bacteria belonging to the Pasteurellaceae family (Gen. Pasteurella, Mannheimia, Actinobacillus, Histophilus, Haemophilus) in pigs, ruminants and horses (1.5 hours). Mycoplasmosis of ruminants and pigs (1.5 hours). Vesicular diseases: Foot-and-mouth disease, swine vesicular disease, Vesicular Exanthema, Vesicular Stomatitis (1.5 hours). Infections sustained by bacteria belonging to the Enterobacteraceae family (Gen. Escherichia coli, Salmonella spp., Klebsiella spp., Yersinia spp.). (1.5 hours) Clostridiosis: Tetanus, Botulism, Gas Gangrene (Blackleg, Malignant Edema), Clostridium perfringens infections (1.5 hours). Neonatal Diarrhea (Rotavirus and Coronavirus Infections), Brachyspira hyodysenteriae infection, Proliferative enteritis sustained by Lawsonia intracellularis (1 hour). Prion diseases: Scrapie, Bovine Spongiformis Encephalitis, Cronic Wasting Disease (1.5 hours). Practical lessons: Diagnostic Protocols in Infectious Diseases (2 hours) Experience on field at a Breeding Station and English Thoroughbred farm (2 hours) Experience on field at a dairy farm (2 hours) Experience on field at a beef cattle farm (2 hours) Experience on field at a sheep farm (2 hours) Experience on field at a pig farm (2 hours) Clinical Rotations (4 hours): Participation in the activities of the Microbiological Diagnostic Laboratory of the Department Veterinary Teaching Hospital. Acceptance of biological samples and medical history. Performing bacteriological and serological examinations, bacterial typification and diagnostic staining. Setting and Interpreting Antimicrobial sensitivity tests.
Reference texts	Farina-Scatozza :Malattie infettive degli animali UTET II° edizione O.M. Radostits, J.H. Arundel, Clive C. Gay: Veterinary Medicine: a textbook of the diseases of cattle, sheep, pigs, goats and horses, Ed. Saunders, 2007, 10 edizione. Sellon-Long: Equine Infectious diseases, Ed. Saunders, 2007 Zimmerman J.J., Karrieker L., Ramirez A., Schwartz K.J., Stevenson G.W.: Diseases of swine. Wiley -Blackwell, 2012. Coetzer J.A.W., Tustin R.C. : Infectious Diseases of livestock., Oxford University 2004. Benazzi P., Il Regolamento di Polizia veterinaria Esculapio 2011. Manuale OIE (Manual of Diagnostic Tests and Vaccines for Terrestrial Animals 2012) http://www.oie.int/international-standard-setting/terrestrial-manual/access-online/) In addition to texts recommended other educational material available is used by the teacher during lessons.
Educational objectives	The main objective of this course is to provide students notions of infectious diseases, knowledge about diagnostic methods used to diagnose diseases and what preventive measures should be taken to limit its spread. More specifically: - Improve basic knowledge skills about the relationships between hosts, pathogens and environment and biosafety measures appliocation and management of health and hygiene in farms. - Know etiopathogenesis, epidemiology, diagnosis, prophylaxis and therapy of infectious diseases of livestock and zoonotic emphasizing their socio-economic significance. - Acquiring diagnostic skills and interpretation of the results obtained. - Know both the national and international legislation on prevention and control. - Knowing both direct and indirect preventive measures and monitoring plans against infectious animal diseases and zoonoses.
Teaching methods	The course is organized as follows: 36 hours of lectures in the classroom on the different topics of the teaching course, in particular related to the etiology, pathogenesis, symptoms, diagnosis and prophylaxis of infectious diseases of cattle, sheeps, goats, pigs and horses; 12 hours of practical lessons (4 student groups) that are carried out in part in the workshops of the Department and the rest at farms (cattle, sheep, pigs, horses). Field activities include identification and assessment of the main risk factors related to infectious diseases (acquisition of vocational skills). During the external activities it will be discussed about any problem present in the farm, by an analysis of the protocols of prophylaxis used in the specific context of production and identification of opportunities for health improvement (acquisition of processing capacity and synthesis; acquisition of communication skills and team work). 4 hours of Clinical rotation ....
Extended program	Theoretical lessons: Course introduction (organization and final exam information). Equine Herpetic infections: EHV-1, EHV-4, EHV-3, EHV-2 and EHV-5 (1.5 hours); Equine viral arteritis (1.5 hours), Influenza viruses (1.5 hours), Equine infectious anemia (1.5 hours), Rhodococcus equi infection, Strangles, Contagious Equine Metritis (1.5 hours). Brucellosis (1.5 hours); Tuberculosis (1.5 hours); Paratuberculosis (1.5 hours); Mastitis (1.5 hours); Bovine rhinotracheitis virus, Parainfluenza-3 virus, Viral Respiratory Syncytial virus (1.5 hours); Bovine Viral Diarrhea / Mucosal Disease virus, Border disease (1.5 hours); Enzootic Bovine Leukosis, Visna-Maedi, Caprine Arthritis Encephalitis virus, Sheep Pulmonary Adenomatosis (1.5 hours) Caseous Lymphadenitis (CLA), Contagious Ecthyma (1 hour), Infectious Abortion in ruminants (1.5 hours). Aujeszky's disease/Pseudorabies (1.5 hours), Classical Swine Fever (1.5 hours), Swine Erysipelas (1 hour), Parvovirosis in pigs, Porcine Reproductive and Respiratory Syndrome, Swine Circovirus (1.5 hours) Diseases sustained by bacteria belonging to the Pasteurellaceae family (Gen. Pasteurella, Mannheimia, Actinobacillus, Histophilus, Haemophilus) in pigs, ruminants and horses (1.5 hours). Mycoplasmosis of ruminants and pigs (1.5 hours). Vesicular diseases: Foot-and-mouth disease, swine vesicular disease, Vesicular Exanthema, Vesicular Stomatitis (1.5 hours). Infections sustained by bacteria belonging to the Enterobacteraceae family (Gen. Escherichia coli, Salmonella spp., Klebsiella spp., Yersinia spp.). (1.5 hours) Clostridiosis: Tetanus, Botulism, Gas Gangrene (Blackleg, Malignant Edema), Clostridium perfringens infections (1.5 hours). Neonatal Diarrhea (Rotavirus and Coronavirus Infections), Brachyspira hyodysenteriae infection, Proliferative enteritis sustained by Lawsonia intracellularis (1 hour). Prion diseases: Scrapie, Bovine Spongiformis Encephalitis, Cronic Wasting Disease (1.5 hours). Practical lessons: Diagnostic Protocols in Infectious Diseases (2 hours) Experience on field at a Breeding Station and English Thoroughbred farm (2 hours) Experience on field at a dairy farm (2 hours) Experience on field at a beef cattle farm (2 hours) Experience on field at a sheep farm (2 hours) Experience on field at a pig farm (2 hours) Clinical Rotations (4 hours): Participation in the activities of the Microbiological Diagnostic Laboratory of the Department Veterinary Teaching Hospital. Acceptance of biological samples and medical history. Performing bacteriological and serological examinations, bacterial typification and diagnostic staining. Setting and Interpreting Antimicrobial sensitivity tests.

SMALL ANIMAL INFECTIOUS DISEASES

Code	GP005420
CFU	2
Teacher	Fabrizio Passamonti
Teachers	Maria Luisa Marenzoni (Codocenza)
Hours	50 ore (Codocenza) - Maria Luisa Marenzoni
Learning activities	Caratterizzante
Area	Discipline delle malattie infettive ed infestive
Academic discipline	VET/05
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Introduction to Infectious Diseases of the animals; Impact of Infectious Diseases in domestic animals; emerging and re-emerging Infectious Diseases; notifiable Infectious Diseases;Transboundary Infectious Diseases, Infectious Diseases in wildlife; zoonosis (3 hours). Leptospirosis (2 hours). Rabies; Coxiellosis (2 hours). Canine Distemper (1.5 hours). Infectious hepatitis; Canine Herpesvirus infection; Kennel Cough and Canine Respiratory Disease Complex 1,5 hours). Lyme Disease; Ehrlichiosis; Rickettsiosis; Anaplasmosis (1.5 hours). Canine Parvovirus infection and Panleukopenia (1.5 hours). Coronavirus infection and Feline Infectious Peritonitis (1.5 hours). Feline Respiartory Disease Complex (infection by Feline Herpesvirus, Calicivirus and Chlamydophila felis) (1.5 hours). Parapoxvirus infection; infection by Mycoplasma haemofelis and haemominutum; Bartonella infection; Feline retroviruses (feline immunodeficiency virus; feline leukemia virus) (2 hours). Diagnostic protocols of infectious diseases in dogs and cats (2 practical hours). Vaccinal protocols in dogs and cats (2 practical hours). Visit to a public kennel and a private one in collaboration with the veterinary services of the territory of Perugia (2 practical hours). Clinical rotation with simulation of submission, processing and execution of biomolecular tests from suspected infectious samples. Interpretation of results of clinical cases present in the database of the hospital (2 practical hours).
Reference texts	C. E. Greene: Infectious Diseases Of The Dog And Cat, Ed. Saunders, 2012, 3° edizione J. E. Sykes, Canine and Feline Infectious Diseases Ed. Elsevier Saunders, 2013, 1 ed. Slides of the lecturer will be available on the system unistudium. The access will be explained during the course.
Educational objectives	The main aim of the course is to make students able to recognize different Infectious Diseases and identify their specific features to diagnose and control them. Main knowledge acquired will be: -general knowledge of Infectious Diseases, their economic and sanitary impact; -concepts of evolution of etiological agents; -features of each etiological agent causing specific Infectious Diseases of dog and cat; epidemiology, pathogenesis, clinical signs, lesions of the Infectious Diseases of dog and cat discussed during the course; -knowledge of the main diagnostic and preventive methods applied for each Infectious Diseases. The main competence will be: -to recognize the main features of each Infectious Diseases of dog and cat; -to apply the best diagnostic procedures in different clinical cases; -to apply the best vaccine protocol, based on the risk/benefit analysis.
Teaching methods	The course is developed in 18 hours face-to-face; 6 hours for practical training (for 4 groups) and 2 hours for clinical rotation (for 12 groups). Each Infectious Disease of dog and cat is described in a face-to-face lesson. Seminars about diagnosis of infectious diseases in different veterinary settings and about vaccine protocols and their possible consequences will be performed. At the end of the course students will visit a public and a private canine and feline shelter.
Extended program	Introduction to Infectious Diseases of the animals; Impact of Infectious Diseases in domestic animals; emerging and re-emerging Infectious Diseases; notifiable Infectious Diseases;Transboundary Infectious Diseases, Infectious Diseases in wildlife; zoonosis (3 hours). Leptospirosis (2 hours). Rabies; Coxiellosis (2 hours). Canine Distemper (1.5 hours). Infectious hepatitis; Canine Herpesvirus infection; Kennel Cough and Canine Respiratory Disease Complex 1,5 hours). Lyme Disease; Ehrlichiosis; Rickettsiosis; Anaplasmosis (1.5 hours). Canine Parvovirus infection and Panleukopenia (1.5 hours). Coronavirus infection and Feline Infectious Peritonitis (1.5 hours). Feline Respiartory Disease Complex (infection by Feline Herpesvirus, Calicivirus and Chlamydophila felis) (1.5 hours). Parapoxvirus infection; infection by Mycoplasma haemofelis and haemominutum; Bartonella infection; Feline retroviruses (feline immunodeficiency virus; feline leukemia virus) (2 hours). Diagnostic protocols of infectious diseases in dogs and cats (2 practical hours). Vaccinal protocols in dogs and cats (2 practical hours). Visit to a public kennel and a private one in collaboration with the veterinary services of the territory of Perugia (2 practical hours). Clinical rotation with simulation of submission, processing and execution of biomolecular tests from suspected infectious samples. Interpretation of results of clinical cases present in the database of the hospital (2 practical hours).

VETERINARY TROPICAL PATHOLOGY

Code	GP005419
CFU	2
Teacher	Fabrizio Passamonti
Teachers	Fabrizio Passamonti
Hours	50 ore - Fabrizio Passamonti
Learning activities	Caratterizzante
Area	Discipline delle malattie infettive ed infestive
Academic discipline	VET/05
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Emphasize the importance in terms of economic and social impact of tropical diseases in the twenty-first century, deepening the aspects related to the mode of diffusion diagnostics and preventive measures. Definition of tropical desease; listing of tropical diseases according to their spreading capability and possibility (1 hour) Diseases caused by viruses : Family Flaviviridae: Japanese encephalitis complex:Usutu virus West Nile Disease Fam. Togaviride: Estern equine encephalitis; Western equine encephalitis; Venezuelan equine encephalitis (3 hours) Fam. Paramyxoviridae:goat plague, Virus Hendra, Virus Nipah (1 hour) Fam. Reoviridae: African horse sickness, Blue tongue (3 hours) Fam. Asfarviridae: African swine fever (1,5 hours) Fam. Bunyaviridae: Schmallenberg disease, Rift valley fever, Nairobi sheep disease (1 hour) Fam. Herpesviridae: Malignant catarrhal fever (1 hour) Fam. Poxviridae: Lumpy skin disease (1 hour). Diseases caused by bacteria: Family Mycoplasmataceae: Contagious bovine pleuropneumonia Fam. Anaplasmataceae: Heartwater; (1,5 hours) Fam. Burkholderiaceae: Glanders, Melioidosis (1,5 hours) Fam. Bacillaceae: Antrax (1,5 hours) Cross-border interventions,interventions at a contry's border, inland interventions (1 hour) Isolation and typing techniques of bacterial and viral agents (3 hours practical lesson) Serological tests (3 hours practical lesson) Clinical rotation (2 hours)
Reference texts	Farina-Scatozza :Malattie infettive degli animali UTET II° edizione O.M. Radostits, J.H. Arundel, Clive C. Gay: Veterinary Medicine: a textbook of the diseases of cattle, sheep, pigs, goats and horses, Ed. Saunders, 2007, 10 edizione. Benazzi P., Il Regolamento di Polizia veterinaria Esculapio 2011. OIE Manual (Manual of Diagnostic Tests and Vaccines for Terrestrial Animals 2012) http://www.oie.int/international-standard-setting/terrestrial-manual/access-online/) Teaching material used by the lecturer during the lesson and available in Unistudium https://www.unistudium.unipg.it
Educational objectives	After completing the course, students will acquire useful knowledge to identify and address a tropical disease. They will have to know how to set up a diagnostic protocol based on both the clinical and pathological characteristics of the etiological agents examined. To know the prophylactic measures both direct and indirect to be put in place in order to limit the spreading of the disease in relation to the provisions in the Regulations of Veterinary Police and the OIE Manual.
Teaching methods	The course is organized as follows: 18 hours - lectures on all the topics of the program; 6 hours - laboratory exercises on the main techniques of isolation and typing of infectious agents, bacteria and viruses, on biomolecular methods and the most used serological tests. The students are divided into 4 groups. 2 hours of clinical rotation: students divided into 11 teams of 5 students, collaborate with the teacher in the management, processing, and execution of laboratory methods from suspected infectious disease etiology
Extended program	Definition of tropical desease; listing of tropical diseases according to their spreading capability and possibility (1 hour) Diseases caused by viruses : Family Flaviviridae: Japanese encephalitis complex:Usutu virus West Nile Disease Fam. Togaviride: Estern equine encephalitis; Western equine encephalitis; Venezuelan equine encephalitis (3 hours) Fam. Paramyxoviridae:goat plague, Virus Hendra, Virus Nipah (1 hour) Fam. Reoviridae: African horse sickness, Blue tongue (3 hours) Fam. Asfarviridae: African swine fever (1,5 hours) Fam. Bunyaviridae: Schmallenberg disease, Rift valley fever, Nairobi sheep disease (1 hour) Fam. Herpesviridae: Malignant catarrhal fever (1 hour) Fam. Poxviridae: Lumpy skin disease (1 hour). Diseases caused by bacteria: Family Mycoplasmataceae: Contagious bovine pleuropneumonia Fam. Anaplasmataceae: Heartwater; (1,5 hours) Fam. Burkholderiaceae: Glanders, Melioidosis (1,5 hours) Fam. Bacillaceae: Antrax (1,5 hours) Cross-border interventions,interventions at a contry's border, inland interventions (1 hour) Isolation and typing techniques of bacterial and viral agents (3 hours practical lesson) Serological tests (3 hours practical lesson) Clinical rotation (2 hours)