Unit CLINICAL SCIENCES

HAEMATOLOGY

Code	50018202
CFU	2
Teacher	Paolo Sportoletti
Teachers	Paolo Sportoletti
Hours	24 ore - Paolo Sportoletti
Learning activities	Caratterizzante
Area	Scienze interdisciplinari cliniche
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	The module in question is intended to bring to the attention of the student the most important hematologic disorders, new diagnostic tests and their correlation with specific diseases. Provides the necessary elements in order to interpret the meaning of changes in the main laboratory tests
Reference texts	MALATTIE DEL SANGUE E DEGLI ORGANI EMOLINFOPOIETICI- Sante Tura - Editrice ESCULAPIO
Educational objectives	It aims to raise awareness and understanding of the student the meaning of laboratory tests for the purpose of major diseases. In particular, it aims to make early detection of diseases that may emerge from the evaluation of the laboratory tests at the end of the course the student should be able to use the acquired knowledge to identify the most common hematologic diseases
Prerequisites	N/A
Teaching methods	Lectures with presentation of reports and case studies that will give students the chance to meet with real cases in order to learn to be inferred from laboratory data sottese diseases and problems related to them.
Other information	N/A
Learning verification modality	The learning and the degree of preparation is checked by written examination concerning the arguments discussed during the lessons. The students must demonstrate that they have acquired adequate knowledge and skills to recognize the main hematological diseases and related alterations of laboratory tests.
Extended program	1) Hematopoiesis: concepts of general biology and laboratory techniques related to the identification and study of hematopoietic stem cells normal and pathological conditions. 2) leukemogenesis: general overview and pathogenetic mechanisms: laboratory tests related to diagnosis, prognosis, response to treatment and monitoring over time. 3) acute myeloid leukemia and acute leukemias LYMPHOID: generali. Esami concepts inherent laboratory diagnosis, prognosis, response to treatment and monitoring over time. 4) lymphoproliferative syndromes CHRONIC: general overview and differential diagnosis between the various lymphoproliferative diseases 5) chronic myeloproliferative disorders: general overview and differential diagnosis between the various myeloproliferative diseases

OCCUPATIONAL MEDICINE

Code	50788102
CFU	2
Teacher	Giacomo Muzi
Teachers	Giacomo Muzi
Hours	24 ore - Giacomo Muzi
Learning activities	Caratterizzante
Area	Scienze della prevenzione e dei servizi sanitari
Academic discipline	MED/44
Type of study-unit	Obbligatorio (Required)

LEGAL MEDICINE

Code	50667601
CFU	1
Teacher	Laura Paglicci Reattelli
Teachers	Laura Paglicci Reattelli
Hours	12 ore - Laura Paglicci Reattelli
Learning activities	Caratterizzante
Area	Scienze della prevenzione e dei servizi sanitari
Academic discipline	MED/43
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Biomedical lab technician activities in the judicial inspection and in the forensic tossicology and medico-legal laboratories.
Reference texts	Paolo Arbarello et al. “Medicina Legale per le Professioni Sanitarie: Diritto, Deontologia, Legislazione Sociale” Ed. Minerva Medica, 2010Material provided by the professorSlides
Educational objectives	Know the judicial inspection operating methods and the forensic tossicology and medico-legal analyses.
Prerequisites	Non ci sono pre-requisiti specifici per questa disciplina
Teaching methods	Lessons
Learning verification modality	Oral or written examination
Extended program	Judicial inspectionExamination of the placeExamination of the corpseSurvey of biological tracesThe identification of tracesTraces of bloodTraces of semenForensic toxicologyRegulatory frameworkNeurodepressing drugsOpiatesBarbituratesEthyl alcoholPsychostimulantCocaineHallucinogenic drugsPreparations of cannabis sativaAmphetaminesLSDEthyl alcohol intoxicationPoisoning by carbon monoxide

MEDICAL ONCOLOGY

Code	50667701
CFU	1
Teacher	Giulio Metro
Teachers	Giulio Metro
Hours	12 ore - Giulio Metro
Learning activities	Caratterizzante
Area	Scienze interdisciplinari cliniche
Academic discipline	MED/06
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italiano
Contents	Fattori predittivi di risposta a terapie biologiche nel carcinoma del colon, carcinoma mammario, melanoma, tumore gastrointestinale stromale; concetti di immunoterapia; principali tecniche di misurazione delle mutazioni genetiche predittive su tessuto tumorale e plasma
Reference texts	Materiale didattico fornito dal docente
Educational objectives	Nell’era della medicina di precisione, la quale comporta una personalizzazione del trattamento sistemico anti-tumorale sempre più selettiva, il presente corso si prefigge lo scopo fornire allo studente il razionale alla base dell’utilizzo delle principali tecniche di biologia molecolare applicata ai tumori solidi, nonché le competenze essenziali per il loro svolgimento
Prerequisites	Non ci sono pre-requisiti specifici per questa disciplina
Teaching methods	Lezioni frontali e dimostrazioni pratiche in laboratorio di oncologia
Learning verification modality	Esame orale
Extended program	Generalità di epidemiologia e carcinogenesi; chemioterapia e meccanismo d’azione; vie di trasduzione del segnale intracellulare; terapia biologica e classificazione (anticorpi monoclonali, anticorpi monoclonali farmaco-coniugati, piccole molecole inibitrici delle tirosino-chinasi); carcinoma del colon, ruolo delle mutazioni di RAS e BRAF nel carcinoma del colon, terapie anti-EGFR nel carcinoma del colon; carcinoma mammario, sottotipi del carcinoma mammario, carcinoma mammario HER2-positivo, misurazione dello stato di HER2, terapie anti-HER2; carcinoma polmonare non microcitoma, sottotipi molecolari nell’adenocarcinoma polmonare, mutazione di EGFR, ALK, ROS1 ed altri “minor drivers” e loro risvolto terapeutico nell’adenocarcinoma polmonare; melanoma, mutazione di BRAF e sensibilità agli inibitori di BRAF +/- inibitori di MEK; tumore gastrointestinale stromale, mutazione C-KIT e sensibilità all’imatinib; immunoterapia nei tumori solidi, generalità ed applicazioni; marcatori di sensibilità all’immunoterapia, PD-L1 e TMB; principali tecniche di sequenziamento genetico su tessuto tumorale per la ricerca di mutazioni predittive di risposta alla terapia biologica con particolare riferimento alla “next-generation sequencing” (NGS); biopsia liquida e sue applicazioni nel trattamento dei tumori solidi, con particolare riferimento al tumore del polmone; metodiche per l’esecuzione della biopsia liquida (real time PCR, digital PCR, NGS)