Unit PHARMACOLOGICAL SCIENCES

ELEMENTS OF CLINICAL PHARMACOLOGY

Code	A001523
CFU	1
Teacher	Alessandro D'arpino
Teachers	Alessandro D'arpino
Hours	12 ore - Alessandro D'arpino
Learning activities	Caratterizzante
Area	Scienze della prevenzione e dei servizi sanitari
Academic discipline	MED/50
Type of study-unit	Obbligatorio (Required)

PHARMACY TOXICOLOGY

Code	A001521
CFU	1
Teacher	Simona Ronchetti
Teachers	Simona Ronchetti
Hours	12 ore - Simona Ronchetti
Learning activities	Base
Area	Primo soccorso
Academic discipline	BIO/14
Type of study-unit	Obbligatorio (Required)
Language of instruction	italian
Contents	Toxicology: general principles, Drug adverse reactions, antidotes, drug-drug interaction, drug-food interactions, pre-clinical and clinical trials
Reference texts	- F. Rossi, V. Cuomo, C. Riccardi, Farmacologia: principi di base e applicazioni terapeutiche, III Edizione, Edizioni Minerva Medica ¿- Rang, Dale, Ritter, Flower. Farmacologia-C.L. Galli, E. Corsini, M. Marinovich, Tossicologia, Piccin
Educational objectives	The course will allow the student to acquire knowledge about the adverse and toxic effects, as well as the therapeutic bases and the administration route of the most important drugs. The student will be aware of those factors that influence the desired pharmacological and undesired toxicologic effects.
Prerequisites	none requested
Teaching methods	face-to-face lessons
Other information	compulsory course attendance
Learning verification modality	written exam
Extended program	Toxicology: general principles, dose-toxic effect relationship, toxicity curves, organ toxicity drug adverse reactions: classification and examplesantidotes: the most important for poisoning. Drug-drug interaction, drug-food interactions, pre-clinical and clinical trials

GENERAL PHARMACOLOGY

Code	A001520
CFU	2
Teacher	Giada Mondanelli
Teachers	Giada Mondanelli
Hours	24 ore - Giada Mondanelli
Learning activities	Base
Area	Primo soccorso
Academic discipline	BIO/14
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Definitions: drug, desired, unwanted and toxic effects. Pharmacokinetics: description of absorption, distribution, metabolism and elimination of drugs. Pharmacodynamics: definition of pharmacologic receptor, classes of receptors and known mechanisms of signal transduction. Overview of clinical pharmacology.
Reference texts	R. Paoletti, S. Nicosia, F Clementi, G. Fumagalli Farmacologia generale e molecolare, EDRA.
Educational objectives	The student will achieve the following skills: 1) understand the concept of drug bioavailability 2) calculate the correct dosage of a drug 2) understand the mechanism of action of a drug 3) understand the relevance of the dose-effect concept
Prerequisites	The student must possess notions of anatomy, physiology and general pathology. The student must also comply with the required prerequisites.
Teaching methods	Lectures on all the topics of the course.
Other information	The student can reach the teacher at the following email address: giada.mondanelli@unipg.it
Learning verification modality	The final exam consists of a multiple choice test.
Extended program	Definition of drug. Features of the conventional drug. Natural and synthetic drugs. Biodrugs and biotechnological drugs. Primary, side, unwanted and toxic effects. Cellular basis of pharmacokinetics (cell barriers and drug transport across membranes). Absorption and routes of drug administration. Distribution, metabolism and elimination of drugs. Interaction between drugs. Pharmacodynamics: receptors and receptor activation theories. Classes of receptors and mechanisms of signal transduction. Agonists, antagonists. Dose-response curve.

PHARMACOLOGY AND TOXICOLOGY METHODS AND TECHNIQUES

Code	A001522
CFU	1
Teacher	Marilena Micheli
Teachers	Marilena Micheli
Hours	18 ore - Marilena Micheli
Learning activities	Caratterizzante
Area	Scienze e tecniche di laboratorio biomedico
Academic discipline	MED/46
Type of study-unit	Obbligatorio (Required)