Unit BLOOD DISEASES
- Course
- Biology
- Study-unit Code
- 50A00126
- Curriculum
- Biosanitario
- Teacher
- Cristina Mecucci
- Teachers
-
- Cristina Mecucci
- Roberta La Starza (Codocenza)
- Enrico Tiacci (Codocenza)
- Hours
- 7 ore - Cristina Mecucci
- 38 ore (Codocenza) - Roberta La Starza
- 7 ore (Codocenza) - Enrico Tiacci
- CFU
- 6
- Course Regulation
- Coorte 2019
- Offered
- 2019/20
- Learning activities
- A scelta dello studente
- Area
- A scelta dello studente
- Academic discipline
- MED/15
- Type of study-unit
- Opzionale (Optional)
- Type of learning activities
- Attività formativa monodisciplinare
- Language of instruction
- Italian
- Contents
- Hematopoiesis (erythropoiesis, granulocytopoiesis, monocytopoiesis, plateletopoiesis, lymphocytopoiesis). Characteristics of blood cells. Mechanisms of gene regulation (gene mutations, chromosomal rearrangements, mutations in non-coding sequences with formation of new enhancers, gene silencing, methylation, role of telomeric and centromeric regions, oncogenes, tumor suppressors
Molecular bases and molecular mechanisms of: Chronic myeloproliferative syndromes
Myelodysplastic syndromes
Acute leukemia (lymphoid and myeloid)
Chronic lymphatic leukemia; non-Hodgkin's lymphomas
Cellular plasma discrasias - Reference texts
- Corso di malattie del sangue e degli organi emolinfopoietici (S.Tura, Esculapio Ed)
Introduzione alla Medicina Molecolare (D Ross, Springer Biomed) - Educational objectives
- At the end of the course the student will have to know the main elements of genetics, and epigenetics, that underlie the pathogenesis and / or progression of onco-hematological diseases
- Prerequisites
- Knowledge of the main causes of the disease and the related etiopathogenetic mechanisms. Basic physiopathological mechanisms of the main systems and systems. Elements of pathological anatomy, histological and cytological examinations
- Teaching methods
- Lessons
excercises - Learning verification modality
- Written open questions
- Extended program
- Hematopoiesis, stem cells, myeloid lineage differentiation and lymphonodes, organs of hematopoiesis (bone marrow, liver, spleen, yolk sac) lymphatic system; Blood: corpuscular elements, plasma.
Diseases of the red blood cell: Anemias (due to iron deficiency, vit b12 and folate, hemoglobinopatio-thalassemia, sickle cell anemia - hemolytic from intrinsic, extrinsic and mixed defect) and polyglobulias (secondary); basic parameters for the diagnostic classification of anemias; blood count, reticulocyte count; leucopenie; thrombocytopenia: thromboctiopenic idiopathic purpura, thrombotic thrombocytopenic purpura; Acute leukemias: LAM, LAL B cells, LAL T cells: clinical and diagnostic tests; chronic myeloproliferative diseases: chronic myeloid leukemia, polycythemia vera, essential thrombocythemia, idiopathic myelofibrosis, chronic eosinophilia leukemia; Myeloid and lymphoid neoplasms with tyrosine kinase involvement FGFR1, PDGFRA, PDGFRB; Chronic lymphatic leukemia, hairy cell leukemia, indolent and aggressive, B-cell and T-cell non-Hodgkin's lymphomas; Monoclonal gammopathies: MGUS, multiple-smoldering and symptomatic myeloma, solitary plasmacytoma of bone; medullary aplasia; Myelodysplastic syndromes; chemotherapy and use of autologous and allogeneic marrow transplantation