Unit SYSTEMIC PATHOLOGY V

BLOOD DISEASES - MOD. 1

Code	GP001451
Location	PERUGIA
CFU	2
Teacher	Brunangelo Falini
Teachers	Andrea Velardi (Codocenza) Brunangelo Falini
Hours	4 ore (Codocenza) - Andrea Velardi 14 ore - Brunangelo Falini
Learning activities	Caratterizzante
Area	Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)

BLOOD DISEASES - MOD. 2

Code	GP001452
Location	PERUGIA
CFU	1
Teacher	Maria Paola Martelli
Teachers	Maria Paola Martelli
Hours	9 ore - Maria Paola Martelli
Learning activities	Caratterizzante
Area	Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)

DISEASES OF THE IMMUNE SYSTEM

Code	GP001449
Location	PERUGIA
CFU	2
Teacher	Andrea Velardi
Teachers	Andrea Velardi
Hours	24 ore - Andrea Velardi
Learning activities	Caratterizzante
Area	Medicina delle attività motorie e del benessere
Academic discipline	MED/09
Type of study-unit	Obbligatorio (Required)

MOLECULAR MEDICINE

Code	GP001453
Location	PERUGIA
CFU	1
Teacher	Cristina Mecucci
Teachers	Cristina Mecucci
Hours	12 ore - Cristina Mecucci
Learning activities	Caratterizzante
Area	Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Approcci tecnologici per lo studio del genoma. - Cellula staminale leucemica e tumorale, processo multistep dell'oncogenesi, meccanismi di alterazione di oncogeni, oncosoppressori, geni del riparo e geni check-point. - Modelli di patogenesi di insufficienze midollari congenite e acquisite. - Modelli di patogenesi di Leucemie Acute. - Tirosinchinasi. - Modelli di patogenesi di disordini linfoproliferativi. - Modelli di patogenesi di Mieloma. - Modelli di patogenesi di tumori solidi (polmone; mammella; colon).
Reference texts	il materiale sarà fornito dal docente.
Teaching methods	lezioni frontali
Learning verification modality	Schede di verifiche a risposta multipla Per informazioni sui servizi di supporto agli studenti con disabilità e/o DSA visita la pagina http://www.unipg.it/disabilita-e-dsa
Extended program	Approcci tecnologici per lo studio del genoma. - Cellula staminale leucemica e tumorale, processo multistep dell'oncogenesi, meccanismi di alterazione di oncogeni, oncosoppressori, geni del riparo e geni check-point. - Modelli di patogenesi di insufficienze midollari congenite e acquisite. - Modelli di patogenesi di Leucemie Acute. - Tirosinchinasi. - Modelli di patogenesi di disordini linfoproliferativi. - Modelli di patogenesi di Mieloma. - Modelli di patogenesi di tumori solidi (polmone; mammella; colon).

REUMATHOLOGY

Code	GP001450
Location	PERUGIA
CFU	2
Teacher	Roberto Gerli
Teachers	Roberto Gerli
Hours	24 ore - Roberto Gerli
Learning activities	Caratterizzante
Area	Clinica delle specialità medico-chirurgiche
Academic discipline	MED/16
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Classification, epidemiology and pathogenesis of rheumatic disease. Clinical features of most common acute and chronic osteoarticular disease, inflammatory and not, of extra-articular rheumatism, of systemic autoimmunitary disease and of systemic vasculitides.
Reference texts	REUMATOLOGIA per studenti e Medici di Medicina Generale; a cura di UNIREUMA. IDELSON GNOCCHI II Ed. 2014. ¿ HARRISON et al. - Principi di Medicina Interna - McGraw Hill Edizione XIX, 2016
Educational objectives	At the end of the Course students are expected to recognize and define the peculiar features of most common chronic articular conditions, both inflammatory and degenerative, extra-articular rheumatic diseases, systemic autoimmune diseases and systemic vasculitis, from an etiologic, pathogenic and, most importantly, clinical point of view. In addition, the students are asked to prove the ability to recognize and interpret the laboratory tests specific for the aforementioned conditions and the most common instrumental procedures employed in rheumatology clinics. The students’ diagnostic approach based on signs and symptoms will also be evaluated.
Teaching methods	16 theoretical hours, 8 practical hours and practical training or seminars.
Learning verification modality	Oral testing after passing written tests.
Extended program	1. Definition, classification and epidemiology of rheumatic diseases 2. The musculoskeletal system: anatomic- functional elements (signs) 3. Etiopathogenetic mechanism of rheumatic diseases 4. Signs and syntoms of rheumatic diseases 5. Laboratory and imaging diagnosis and synovial liquid analysis 6. Articular inflammatory reumatism i. Rheumatoid arthritis and other arthritis ii. Spondyloarthropathies (overview) iii. Ankylosing Spondylitis iv. Reactive arthritis v. Psoriatic arthritis vi. Enteropathic arthropaties 7. Connective tissue disease i. Systemic Lupus erythematosus ii. Antiphospholipid syndrome iii. Systemic Sclerosis iv. Polymyositis/ Dermatomyositis v. Sjögren syndrome vi. Overlap syndrome vii. Undifferentiated connective tissue diseases (UCTD) 8. Primitive systemic vasculitides i. Large sized-arteries: Takayasu arteritis, temporal arteritis ii. Medium -sized arteries: polyarteritis nodosa iii. Medium and small-sized arteries ANCA-associated ( Wegener's granulomatosis, Churg-Strauss syndrome, micropolyangiitis) iv. Small- sized arteries (Schönlein-Henoch purpura, cryoglobulinemia) 9. Secondary systemic vasculitides 10. Behçet's syndrome 11. Polymyalgia rheumatica 12. Septic and post-infective arthritis (rheumatic fever) 13. Microcrystal arthropaties (Gout, Calcium pyrophosphate dihydrate and hydroxyapatite deposition disorders) 14. Osteoarthrosis 15. Localized extra-articular rheumatic diseases and fibromyalgia 16. Neurovascular and neurologic syndrome i. Algodystrophi syndrome ii. Raynaud 's phenomenon 17. Miscellaneous disorders associated with articular manifestations i. Sarcoidosis ii. Amyloidosis

PROFESSIONALISING TRAINING IN BLOOD DISEASES

Code	GP001456
Location	PERUGIA
CFU	1
Teacher	Roberto Gerli
Learning activities	Altro
Area	Tirocini formativi e di orientamento
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)

Canale A

CFU

1

Teacher

Brunangelo Falini

Teachers

• Brunangelo Falini

Hours

• 20 ore - Brunangelo Falini

Canale B

CFU

1

Teacher

Maria Paola Martelli

Teachers

• Maria Paola Martelli

Hours

• 20 ore - Maria Paola Martelli

PROFESSIONALISING TRAINING IN DISEASES OF THE IMMUNE SYSTEM

Code	GP001454
Location	PERUGIA
CFU	1
Teacher	Roberto Gerli
Learning activities	Altro
Area	Tirocini formativi e di orientamento
Academic discipline	MED/09
Type of study-unit	Obbligatorio (Required)

Canale A

CFU

1

Teacher

Andrea Velardi

Teachers

• Andrea Velardi

Hours

• 20 ore - Andrea Velardi

Canale B

CFU

1

Teacher

Antonio Pierini

Teachers

• Antonio Pierini

Hours

• 20 ore - Antonio Pierini

PROFESSIONALISING TRAINING IN MOLECULAR MEDICINE

Code	GP001457
Location	PERUGIA
CFU	1
Teacher	Cristina Mecucci
Learning activities	Altro
Area	Tirocini formativi e di orientamento
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)

Canale A

CFU

1

Teacher

Cristina Mecucci

Teachers

• Cristina Mecucci

Hours

• 20 ore - Cristina Mecucci

Canale B

CFU

1

Teacher

Cristina Mecucci

Teachers

• Cristina Mecucci

Hours

• 20 ore - Cristina Mecucci

Language of instruction

Italian

PROFESSIONALISING TRAINING IN REUMATHOLOGY

Code	GP001455
Location	PERUGIA
CFU	1
Teacher	Roberto Gerli
Learning activities	Altro
Area	Tirocini formativi e di orientamento
Academic discipline	MED/16
Type of study-unit	Obbligatorio (Required)

Canale A

CFU

1

Teacher

Roberto Gerli

Teachers

• Roberto Gerli

Hours

• 20 ore - Roberto Gerli

Language of instruction

Italian

Contents

Clinical activity with Rheumatologist, included clinical history, physical examination, diagnosis and therapeutic prescription; infusion of biotechnological agents; instrumental diagnosis by ultrasound evaluation of muscle-skeletal areas and ultrasound-driven interventions for joints, tendons, ...; diagnosis of microcirculation disorders by capillaroscopic examination; evaluations of foot and posture disorders.

Reference texts

REUMATOLOGIA per studenti e Medici di a cura di UNIREUMA. IDELSON GNOCCHI II Ed. 2014. ¿ HARRISON et al. Principles of Internal Medicin 19th McGraw Hill Edizione XIX, 2016

Educational objectives

Results based on check of the acquired ability, behavior and interaction degree of the student.

Teaching methods

Partecipation to the above described activities

Canale B

CFU

1

Teacher

Alessia Alunno

Teachers

• Alessia Alunno

Hours

• 20 ore - Alessia Alunno