Unit GENERAL PATHOLOGY AND PHYSIOPATHOLOGY
- Course
- Medicine and surgery
- Study-unit Code
- A000347
- Location
- PERUGIA
- Curriculum
- In all curricula
- CFU
- 8
- Course Regulation
- Coorte 2017
- Offered
- 2018/19
- Type of study-unit
- Obbligatorio (Required)
- Type of learning activities
- Attività formativa integrata
GENERAL PATHOLOGY AND PHYSIOPATHOLOGY - MOD. 1
| Code | A000348 |
|---|---|
| Location | PERUGIA |
| CFU | 6 |
| Learning activities | Caratterizzante |
| Area | Patologia generale e molecolare, immunopatologia, fisiopatologia generale, microbiologia e parassitologia |
| Academic discipline | MED/04 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 6
- Teacher
- Andrea Bartoli
- Teachers
- Andrea Bartoli
- Hours
- 72 ore - Andrea Bartoli
- Language of instruction
- Italian
- Contents
- CONCEPT OF DISEASE
INTRINSIC CAUSES - genetic pathology and congenital disorders; genomic medicine - Reference texts
- Robbins & Cotran LE BASI PATOLOGICHE DELLE MALATTIE 8ø EDIZIONE. Elsevier Italia.
Pontieri. Patologia e Fisiopatologia Generale. UTET - Educational objectives
- The main objective of this moduleis to provide students with the foundation for studying the causes of intrinsic (genetic and congenital) diseases.
The main knowledge gained in this form will be:
•meaning of health and disease
• knowledge about the genetic mutations and the molecular pathology;
• effects of chromosomal alterations;
• assessment of the differences between genetic diseases and congenital diseases;
•elements of genomic medicine
The main skill expectations will to acquire the basic knowledge on the molecular mechanisms to provide adequate basis for a correct clinical approach to diseases and to evaluate and use the information obtained from the main biomedical diagnostic techniques. - Prerequisites
- The acquisitionof of an in deep knowledge of main topics in the course of General Pathology, requires relevant knowledge on Biology and Genetics, Biochemistry and Physiology. The skill so btained in these disciplines are essential so that students can understand the concepts of etiopathology of Molecular and Cellular Pathology and Pathophysiology of organs. The student so well prepared in teaching the course will draw a considerable profit.
- Teaching methods
- Lectures with discussion of the topics of the module.
Discussions on current literature.
Laboratory exercises on demand - Learning verification modality
- The student evaluation consists of an oral exam at the end of the course lessons. The assessment of the preparation of the student lasts an average of thirty minutes depending on the degree of knowledge of the topics covered and the presentation skills of the student. The test consists of three questions regarding the discipline studied related to: molecular and cellular pathology of the intrinsic and extrinsic causes of disease; cellular pathology and molecular oncology and inflammation; general pathophysiology of organs. The questions are administered by different teachers to ensure maximum consistency and objectivity of evaluation. The oral examination is essential for the assessment of the knowledge acquired by the students, exhibition of his skills and mastery of the subject studied with particular referenceto the ability to link between different topics.
- Extended program
- CONCEPT OF DISEASE
Health status and causes of disease. Concept of etiology and pathogenesis.
INTRINSICCAUSES-PATHOLOGYANDGENETICSCONGENITA
Experimental models of genetic diseases.
Monogenic autosomal and eterochromosomal diseases. Genetic heterogeneity, allelic heterogeneity, interaction between genesand their products, gene-environment interactions, dynamic and somatic mutations, epigenetic modifications.
DNA mutationsandrepair mechanisms.
Genetic susceptibility to disease in humans. Concept of penetrance and expressivity.
Pathology of blood genetic diseases: Thalassemia - Spherocytosis - Depranocytosis - Hemophilia. Deficiency of G-6-PD.
Muscular dystrophies.
Metabolism of amino acids: Fenilchetonuria- Albinismo- AKU.
Mutation of receptor proteins and transport systems: cysticfibrosis, familial hypercholesterolemia.
Deficit of lysosomal enzymes: Wolman disease, lipidosis, gangliosidosis, mucopolysaccharidosis and glycogen storage.
Mutation of extracellular structural proteins: Hereditary pathology of collagen (S. Ehler's Danlos) hereditary pathology of elastic fibers (S. Marfan).
Diseases from mitochondrial DNA mutations and Impriniting.
Complex diseases and multifactorial inheritance.
Chromosomal alterations. Numerical and structural chromosome abnormalities: Down syndrome, Turner's syndrome and Klinefelter's syndrome.
Brief Analysis of gene instrumental in the diagnosis of human diseases and Genomic Medicine.
Embryopathies and fetopathies (physical,infectious, endocrineandtoxic mechanisms).
Cognomi M-Z
- CFU
- 6
- Teacher
- Francesco Grignani
- Teachers
- Francesco Grignani
- Hours
- 72 ore - Francesco Grignani
GENERAL PATHOLOGY AND PHYSIOPATHOLOGY - MOD. 2
| Code | A000349 |
|---|---|
| Location | PERUGIA |
| CFU | 1 |
| Learning activities | Caratterizzante |
| Area | Patologia generale e molecolare, immunopatologia, fisiopatologia generale, microbiologia e parassitologia |
| Academic discipline | MED/04 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 1
- Teacher
- Giuseppe Servillo
- Teachers
- Andrea Bartoli (Codocenza)
- Hours
- 12 ore (Codocenza) - Andrea Bartoli
- Language of instruction
- Italian
- Contents
- CELLULAR PATHOLOGY - Mechanisms of cell damage, degeneration and adaptive phenomena. Cell death, autophagy, cell senescence.
Regeneration and repair - Reference texts
- Robbins & Cotran LE BASI PATOLOGICHE DELLE MALATTIE 8ø EDIZIONE. Elsevier Italia.
Pontieri. Patologia e Fisiopatologia Generale. UTET - Educational objectives
- main objective of this module is to provide students with the foundation to address the study of the pathological effectson cells and tissues, consolidating prior knowledge to understand the pathological processes from the molecule to the cell, as the basis of the pathophysiological phenomena.
The main knowledge gained in this form will be:
• cell responses to different causes of disease and its consequences and molecular pathophysiology;
• cell death, autophagy, cell senescence
• adaptive phenomena
•Repair and Regeneration
The main skill expectations will be the basic knowledge on the molecular causes of disease to provide adequate preparation to the correct clinical approach to diseases and to evaluate andu se the information from the main biomedical diagnostic techniques. - Prerequisites
- The acquisition of of an in deep knowledge of main topics in the course of General Pathology, requires relevant knowledge on Biology and Genetics, Biochemistry and Physiology. The skill so btained in these disciplines are essential so that students can understand the concepts of etiopathology of Molecular and Cellular Pathology and Pathophysiology of organs. The student so well prepared in teaching the course will draw a considerable profit.
- Teaching methods
- Lectures with discussion of the topics of the module.
Discussions on current literature.
Laboratory exercises on demand - Learning verification modality
- The student evaluation consists of an oral exam at the end of the course lessons. The assessment of the preparation of the student lasts an average of thirty minutes depending on the degree of knowledge of the topics covered and the presentation skills of the student. The test consists of three questions regarding the discipline studied related to: molecular and cellular pathology of the intrinsic and extrinsic causes of disease; cellular pathology and molecular oncology and inflammation; general pathophysiology of organs. The questions are administered by different teachers to ensure maximum consistency and objectivity of evaluation. The oral examination is essential for the assessment of the knowledge acquired by the students, exhibition of his skills and mastery of the subject studied with particular referenceto the ability to link between different topics.
- Extended program
- CELLULAR PATHOLOGY
Mechanisms of cellular damage.
Vacuolar, cloudy swelling and hydropic degeneration. Hyaline degeneration. Steatosis.
Extracellular degenerative processes . Amyloidosis. Hyaline, fibrinoidandmucous degeneration.
Extracellular matrix and its components: structure, biosynthesis and degradation of matrix components and its alterations. Cell-matrix interactions and their alterations. Fibrosis, cirrhosis, sclerosis.
Cell death. Necrosis. Various types ofnecrosis.Gangrene. The resultsof thenecrotic process. Autolysis. Necroptosis and pyroptosis. Apoptosis. Molecular eventsof the apoptotic death.
Pathological pigmentations. Calcification and heterotopic ossification. Autophagy. Cellular senescence.
Adaptive phenomena: atrophies physiological and pathological causes. Ipetrophies physiological and pathological conditions.
Outcomes of tissue damage (with introductionto inflammation): molecular mechanisms of regeneration and repair.
Cognomi M-Z
- CFU
- 1
- Teacher
- Francesco Grignani
- Teachers
- Francesco Grignani
- Hours
- 12 ore - Francesco Grignani
GENERAL PATHOLOGY AND PATHOPHYSIOLOGY - MOD. 3
| Code | GP004612 |
|---|---|
| Location | PERUGIA |
| CFU | 1 |
| Learning activities | Caratterizzante |
| Area | Patologia generale e molecolare, immunopatologia, fisiopatologia generale, microbiologia e parassitologia |
| Academic discipline | MED/04 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 1
- Teacher
- Giuseppe Servillo
- Teachers
- Giuseppe Servillo
- Hours
- 12 ore - Giuseppe Servillo
- Language of instruction
Italian- Contents
Molecular basis of extrinsic causes of pathology in human.- Reference texts
-PONTIERI FRATI, RUSSO: - Due Volumi- Patologia Generale. Fisiopatologia Generale Ed. PICCIN
-DIANZANI : Istituzioni di Patologia Generale Ed. UTET- Educational objectives
Module 3 of General Pathology is part of the teaching of General Pathology, the Degree in Medicine and Surgery, who studies the causes (etiology) and pathological phenomena at the molecular and cellular disease than the biology and physiology of cell. The course intends to acquire knowledge about the basic mechanisms underlying the most common diseases in humans and the cell response to changes in the external environment. The main objective of the course is to acquire knowledge about:
• intrinsic molecular pathology
• causes physical, chemical and biological disease
• molecular mechanisms of cell death
The oral examination and optional seminars are tools to assess the degree of learning and the ability to communicate and explain, in a simple, yet rigorous, immediate and thorough knowledge gained. The skills acquired in the study of this discipline allows the student to achieve a broad overview of the relationship between the human genome, the environment and the development of diseases and allows to obtain the means to have a clear picture of the causes of pathologies and their specific mechanism of occurrence and development and general pathophysiology of the most common diseases in order to propose behaviors and appropriate treatment as a future Medical Doctor.- Prerequisites
The acquisitionof of an in deep knowledge of main topics in the course of General Pathology, requires relevant knowledge on Biology and Genetics, Biochemistry and Physiology. The skill so btained in these disciplines are essential so that students can understand the concepts of etiopathology of Molecular and Cellular Pathology and Pathophysiology of organs. The student so well prepared in teaching the course will draw a considerable profit.- Teaching methods
To the students are given lectures. The lectures deal with the part of the program of the course of study on the extrinsic causes of disease, with greater reference to the Environmental Pathology, issues of common disorders, that the future physician will face in the course of his profession. Each lesson has a duration of two hours that is given to the specific topic, relating it to others already exposed, to allow the student to have a broad vision of the topics covered. Students are proposed to conduct, at its option, seminars about the arguments in class. The seminars were held in groups of two or three people. The seminars were held in groups of two or three students in the presence of the other students in the course. To this end, the teacher provides students with bibliographical material in English concerning the subject, the subject of the seminar will be presented using computer media (Power-Point and / or similar).- Learning verification modality
The student evaluation consists of an oral exam at the end of the course lessons. The assessment of the preparation of the student lasts an average of thirty minutes depending on the degree of knowledge of the topics covered and the presentation skills of the student. The test consists of three questions regarding the discipline studied related to: molecular and cellular pathology of the intrinsic and extrinsic causes of disease; cellular pathology and molecular oncology and inflammation; general pathophysiology of organs. The questions are administered by different teachers to ensure maximum consistency and objectivity of evaluation. The oral examination is essential for the assessment of the knowledge acquired by the students, exhibition of his skills and mastery of the subject studied with particular referenceto the ability to link between different topics.- Extended program
Extrinsic Causes of Disease -Physical agents. Non ionizing and ionizing radiation. Low and high temperature: freezing and burn. Electric and electromagnetic energy. -Chemical and Environmental agents. Environment pollution, Drugs. -Alimentary causes. Vitamins: A, D, E, K, B and C group. -Free Radical: Oxidative stress. -Causes of Embryopathy and Fetopathy: physical, infective, endocrine and toxic.
Cognomi M-Z
- CFU
- 1
- Teacher
- Francesco Grignani
- Teachers
- Francesco Grignani
- Hours
- 12 ore - Francesco Grignani