Unit GENERAL PATHOLOGY AND PATHOPHYSIOLOGY

GENERAL PATHOLOGY AND PATHOPHYSIOLOGY - MOD. 4

Code	GP005764
Location	PERUGIA
CFU	3
Teacher	Francesco Grignani
Teachers	Francesco Grignani
Hours	36 ore - Francesco Grignani
Learning activities	Caratterizzante
Area	Formazione clinica interdisciplinare e medicina basata sulle evidenze
Academic discipline	MED/04
Type of study-unit	Obbligatorio (Required)

GENERAL PATHOLOGY AND PATHOPHYSIOLOGY - MOD. 5

Code	GP005765
Location	PERUGIA
CFU	2
Teacher	Francesco Grignani
Teachers	Francesco Grignani
Hours	24 ore - Francesco Grignani
Learning activities	Caratterizzante
Area	Formazione clinica interdisciplinare e medicina basata sulle evidenze
Academic discipline	MED/04
Type of study-unit	Obbligatorio (Required)

GENERAL PATHOLOGY AND PATHOPHYSIOLOGY - MOD. 6

Code	GP005766
Location	PERUGIA
CFU	2
Teacher	Luigina Romani
Teachers	Luigina Romani
Hours	24 ore - Luigina Romani
Learning activities	Caratterizzante
Area	Formazione clinica interdisciplinare e medicina basata sulle evidenze
Academic discipline	MED/04
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	The essential elements of the course are: The inflammation Alteration of the immune system.
Reference texts	G.M. Pontieri, M.A. Russo, L. Frati - Patologia Generale - Ed. Piccin Robbins e Cotran - Le basi patologiche delle malattie - Ed. Elsevier E. Rubin - Patologia. Fondamenti clinico patologici in medicina - Ed. Ambrosiana
Educational objectives	At the end of the course students are expected to have obtained sufficient basic knowledge on molecular aspects of inflammation and oncogenesis, as well as on elements of the pathophysiology of organs and systems, with the intent to provide clinical perspectives.
Teaching methods	Frontal lessons
Learning verification modality	Oral exam
Extended program	The inflammation - General characters. Definition of inflammation. Distinguishing acute vs chronic inflammation. - Acute exudative inflammation (Angiophlogosis). The phases. The plasma and tissue mediators. The exudation: the different types of exudate. The acute phase proteins. The cells of acute inflammation. Diapedesis, chemotaxis and phagocytosis. The different types of acute inflammation: serous, sero-fibrinous, fibrinous, catarrhal, purulent, hemorrhagic, necrotic and allergic. - Chronic Inflammation (Istoflogosi). The cells of chronic inflammation. - Chronic inflammation: interstitial and granulomatous. Structure of granuloma: tuberculoma, chancre, rheumatic nodule, leproma, granuloma of viral origin, foreign body granuloma. - Outcome of inflammatory process. The repair processes and the granulation tissue. Alteration of the immune system - Pathology of the monocyte-macrophage system. - Type I, II, III and IV Hypersensitivity - Diseases and major histocompatibility system. - Immunodeficiencies. Autoimmune diseases. - Transplants and the mechanism of acute and chronic rejection. - Intestinal microbiota and inflammation - New anti-inflammatory drugs - Drugs and biological therapy