Unit SYSTEMIC PATHOLOGY V
- Course
- Medicine and surgery
- Study-unit Code
- GP004561
- Location
- PERUGIA
- Curriculum
- In all curricula
- Teacher
- Roberto Gerli
- CFU
- 12
- Course Regulation
- Coorte 2015
- Offered
- 2018/19
- Type of study-unit
- Obbligatorio (Required)
- Type of learning activities
- Attività formativa integrata
BLOOD DISEASES - MOD. 1
Code | GP004621 |
---|---|
Location | PERUGIA |
CFU | 2 |
Teacher | Brunangelo Falini |
Teachers |
|
Hours |
|
Learning activities | Caratterizzante |
Area | Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica |
Academic discipline | MED/15 |
Type of study-unit | Obbligatorio (Required) |
Language of instruction | Italian |
Contents | Blood Diseases |
Reference texts | Harrison's - Principles of Internal Medicine Hoffbrand/Moss - Essential Haematology Bosi, De Stefano, Di Raimondo, La Nasa - Manuale di Malattie del sangue Avvisati - Ematologia di Mandelli Hoffman - Hematology basic priniples and practice |
Educational objectives | The general objective of education is to provide students with the foundation to address the study of blood diseases (either malignant or not). The main skills that will be acquired: - Analyze a CBC - Identify the diagnostic procedure for alterations in the numbers of blood elements - Identify the diagnostic procedure in case of lymphadenopathy - Identify the diagnostic procedure in case of splenomegaly |
Teaching methods | The course is organized as follows: - Lectures on the main topics of the course - Discussion of clinical cases to completion of the main topics |
Learning verification modality | ORAL EXAM |
Extended program | The myeloproliferative syndromes: - Chronic myeloid leukemia - Idiopathic myelofibrosis - Polycythemia Vera - Essential thrombocythemia The myelodysplastic syndromes The acute leukemias - Acute myeloid and lymphoid leukemias - Classification and clinical presentation. - Key molecular alterations associated - Examples of 'target' therapy Chronic lymphoproliferative disorders: - Chronic lymphocytic leukemia - The hairy cell leukemia The malignant lymphomas - Hodgkin's disease - Non-Hodgkin's Lymphoma The monoclonal gammopathy - MGUS - Multiple Myeloma - Waldenstrom's Macroglobulinemia Transfusion therapy: treatment with blood components or blood components |
BLOOD DISEASES - MOD. 2
Code | GP004622 |
---|---|
Location | PERUGIA |
CFU | 1 |
Teacher | Maria Paola Martelli |
Teachers |
|
Hours |
|
Learning activities | Caratterizzante |
Area | Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica |
Academic discipline | MED/15 |
Type of study-unit | Obbligatorio (Required) |
Language of instruction | Italian |
Contents | The anemias The thrombocytopenia Issues of general haematological interest |
Reference texts | Harrison's - Principles of Internal Medicine Hoffbrand/Moss - Essential Haematology Bosi, De Stefano, Di Raimondo, La Nasa – Manuale di Malattie del Sangue Avvisati – Ematologia di Mandelli Hoffman - Hematology basic principles and practice |
Educational objectives | Acquisition of knowledge on the main causes of changes in blood count and in particular of anemias and platelets. Differential diagnostic capacity within the various morbid conditions. |
Prerequisites | In order to understand and know how to tackle the course, students must have the basic understanding on: - Physiology of blood, features and functions of the elements of blood (leukocytes, erythrocytes and platelets) - Anatomy, organization and functions of the lymphatic system - Cellular and humoral immunity - Structure of the bone marrow and hematopoiesis - The blood count - Principles of Serum protein electrophoresis - The monoclonal antibodies |
Teaching methods | - Lectures on the main topics of the course - Discussion of clinical cases to completion of the main topics |
Other information | None |
Learning verification modality | The assessment method includes an oral test which will assess the acquired knowledge and the ability of the student to communicate and reason in front of a specific question. The oral exam consists of a discussion-interview related to the topics covered during the course or otherwise provided for by the program and in-depth on the recommended texts. For the teaching of Blood Diseases will be addressed a topic of oncohematological pathology and one of non-oncohematological pathology. |
Extended program | The anemias: - General aspects of anemia and erythropoiesis - Classification of anemia: a. etiopathogenetic; b. morphological - Morphological alterations of red blood cells. The smear of peripheral venous blood - Iron deficiency anemia - Megaloblastic Anemia and other macrocytic anemias - Anemia of chronic disorders - Hemolytic anemias Hemolytic hereditary disorders Extraglobular causes of hemolytic disorders - Thalassemias - Aplastic anemia and other selective cytopenias (erythroblastopenia isolated, neutropenia and thrombocytopenia) - Differential diagnosis of anemic syndromes. Discussion of clinical cases and diagnostic work. The thrombocytopenia. - Idiopathic Thrombocytopenia Purpura - Thrombotic thrombocytopenia purpura Issues of general haematological interest: - Numerical changes of blood elements: a. differential diagnosis of erythrocytosis b. leukopenia and leukocytosis (lymphopenia and lymphocytosis, neutropenia and neutrophilia) c. thrombocytopenia and thrombocytosis - Splenomegaly. - Splenectomy. Indications in hematology and complications - Lymphadenopathy: Differential Diagnosis - Hematological alterations in systemic diseases |
DISEASES OF THE IMMUNE SYSTEM
Code | GP005656 |
---|---|
Location | PERUGIA |
CFU | 2 |
Teacher | Andrea Velardi |
Teachers |
|
Hours |
|
Learning activities | Caratterizzante |
Area | Medicina delle attività motorie e del benessere |
Academic discipline | MED/09 |
Type of study-unit | Obbligatorio (Required) |
Language of instruction | Italian |
Contents | Diseases of the Immune System |
Reference texts | HARRISON " MEDICINE INTERNAL" |
Educational objectives | At the end of the course the student will have to be able to know and to frame, from a clinical and diagnostic point of view , the main diseases of the immunity system., pimary and secondary systemic autoimmunities and immunodeficiency. |
Prerequisites | It is mandatory that students already passed the exams of physiology and general pathology to allow a global comprehension of the topics included in the course. |
Teaching methods | the course is organized in the following way: lecture on all subjects of the course practices that the students, divided in small groups, they will hold both in ambulatory that in department |
Learning verification modality | The exam includes a multiple choice written test (30 questions with up to 5 possible answers of which only 1 correct). Questions will cover all rheumatology topics and can be afforded with a basic knowledge of such topics. The oral exam is open to students who passed the first written test and includes wider questions aimed at evaluating theoretical and practical skills as well as deductive processes and communication. |
Extended program | The immunodeficiencies: pathogenic mechanisms and risk nfettivo diagnosis of immunodeficiencies. Primary immunodeficiencies: Antibody deficiency diseases: X-linked agammaglobulinemia, Camune Variable immunodeficiency, IgA deficiency. Severe Combined Immunodeficiency: Interleukin receptor gamma chain deficiency, recombinase activating gene deficiency. Immunodeficiencies deficit granulocyte function: Chronic Granulomatous Disease The immunideficienze secondary AIDS: immunopatogeensi, natural history of the disease, the main clinical features. Secondary immunodeficiencies (not AIDS): after splenectomy In the course of lymphoproliferative disorders In the course of immunosuppressive and cytostatic After transplantation of hematopoietic cells, etc.. Immediate hypersensitivity diseases: Urticaria and angioedema, food Allergies Allergic rhinitis, Asthma. Autoimmune diseases: Immunological pathogenesis of organ-specific autoimmune diseases principalei: Hashimoto's thyroiditis, diabetes mellitus, multiple sclerosis, aplastic anemia, and autoimmune pistrinipenie, etc.. Immune diseases (vasculitis): immunopathogenesis and clinical pictures: From genes Infected: Schonlein-Henoch purpura, hepatitis .. The malettia serum drug and vasculitis. Sindromei clinical immune complex amlattie associated with systemic autoimmune (SLE, RA etc;) with cancer. the crioglobulinemie The systemic vasculitinecrotizzanti: immunopathogenesis and clinical pictures: Panarteritis Gnarled, microscipica polyangiitis, Churg-Strauss disease Wegener's granulomatosis Aterite time Disease Behce Systemic autoimmune diseases: immunopathogenesis and clinical Systemic lupus erythematosus Scleroderma and overlap syndromes sarcoidosis |
MOLECULAR MEDICINE
Code | GP004623 |
---|---|
Location | PERUGIA |
CFU | 1 |
Teacher | Cristina Mecucci |
Teachers |
|
Hours |
|
Learning activities | Caratterizzante |
Area | Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica |
Academic discipline | MED/15 |
Type of study-unit | Obbligatorio (Required) |
Language of instruction | Italian |
Contents | Technological approaches for the study of the genome. - Leukemic and tumor stem cells, multistep process of oncogenesis, mechanisms of alteration of oncogenes, tumor suppressors, shelter genes and check-point genes. - Models of pathogenesis of congenital and acquired medullary insufficiencies. - Models of pathogenesis of Acute Leukemia. - Tyrosinchinase. - Pathogenesis models of lymphoproliferative disorders. - Myeloma pathogenesis models. - Models of pathogenesis of solid tumors (lung, breast, colon). |
Reference texts | The material will be provided by the professor |
Teaching methods | Frontal lessons Seminars |
Learning verification modality | Multiple choice quiz |
Extended program | Technological approaches for the study of the genome. - Leukemic and tumor stem cells, multistep process of oncogenesis, mechanisms of alteration of oncogenes, tumor suppressors, shelter genes and check-point genes. - Models of pathogenesis of congenital and acquired medullary insufficiencies. - Models of pathogenesis of Acute Leukemia. - Tyrosinchinase. - Pathogenesis models of lymphoproliferative disorders. - Myeloma pathogenesis models. - Models of pathogenesis of solid tumors (lung, breast, colon). |
REUMATHOLOGY
Code | GP005657 |
---|---|
Location | PERUGIA |
CFU | 2 |
Teacher | Roberto Gerli |
Teachers |
|
Hours |
|
Learning activities | Caratterizzante |
Area | Clinica delle specialità medico-chirurgiche |
Academic discipline | MED/16 |
Type of study-unit | Obbligatorio (Required) |
Language of instruction | Italian |
Contents | Classification, epidemiology and pathogenesis of rheumatic disease. Clinical features of most common acute and chronic osteoarticular disease, inflammatory and not, of extra-articular rheumatism, of systemic autoimmunitary disease and of systemic vasculitides. |
Reference texts | UNIREUMA - REUMATOLOGIA per studenti e Medici di Medicina Generale; edizioni IDELSON-GNOCCHI III ed. 2018. HARRISON et al. - Principi di Medicina Interna - McGraw Hill Edizione XIX, 2016 |
Educational objectives | At the end of the Course students are expected to recognize and define the peculiar features of most common chronic articular conditions, both inflammatory and degenerative, extra-articular rheumatic diseases, systemic autoimmune diseases and systemic vasculitis, from an etiologic, pathogenic and, most importantly, clinical point of view. In addition, the students are asked to prove the ability to recognize and interpret the laboratory tests specific for the aforementioned conditions and the most common instrumental procedures employed in rheumatology clinics. The students’ diagnostic approach based on signs and symptoms will also be evaluated. |
Teaching methods | 16 theoretical hours, 8 practical hours and practical training or seminars. |
Learning verification modality | Oral testing after passing written tests. |
Extended program | 1. Definition, classification and epidemiology of rheumatic diseases 2. The musculoskeletal system: anatomic- functional elements (signs) 3. Etiopathogenetic mechanism of rheumatic diseases 4. Signs and syntoms of rheumatic diseases 5. Laboratory and imaging diagnosis and synovial liquid analysis 6. Articular inflammatory reumatism i. Rheumatoid arthritis and other arthritis ii. Spondyloarthropathies (overview) iii. Ankylosing Spondylitis iv. Reactive arthritis v. Psoriatic arthritis vi. Enteropathic arthropaties 7. Connective tissue disease i. Systemic Lupus erythematosus ii. Antiphospholipid syndrome iii. Systemic Sclerosis iv. Polymyositis/ Dermatomyositis v. Sjögren syndrome vi. Overlap syndrome vii. Undifferentiated connective tissue diseases (UCTD) 8. Primitive systemic vasculitides i. Large sized-arteries: Takayasu arteritis, temporal arteritis ii. Medium -sized arteries: polyarteritis nodosa iii. Medium and small-sized arteries ANCA-associated ( Wegener's granulomatosis, Churg-Strauss syndrome, micropolyangiitis) iv. Small- sized arteries (Schönlein-Henoch purpura, cryoglobulinemia) 9. Secondary systemic vasculitides 10. Behçet's syndrome 11. Polymyalgia rheumatica 12. Septic and post-infective arthritis (rheumatic fever) 13. Microcrystal arthropaties (Gout, Calcium pyrophosphate dihydrate and hydroxyapatite deposition disorders) 14. Osteoarthrosis 15. Localized extra-articular rheumatic diseases and fibromyalgia 16. Neurovascular and neurologic syndrome i. Algodystrophi syndrome ii. Raynaud 's phenomenon 17. Miscellaneous disorders associated with articular manifestations i. Sarcoidosis ii. Amyloidosis |
PROFESSIONALISING TRAINING IN BLOOD DISEASES
Code | GP004624 |
---|---|
Location | PERUGIA |
CFU | 1 |
Teacher | Brunangelo Falini |
Teachers |
|
Hours |
|
Learning activities | Altro |
Area | Tirocini formativi e di orientamento |
Academic discipline | MED/15 |
Type of study-unit | Obbligatorio (Required) |
PROFESSIONALISING TRAINING IN DISEASES OF THE IMMUNE SYSTEM
Code | GP005658 |
---|---|
Location | PERUGIA |
CFU | 1 |
Teacher | Andrea Velardi |
Teachers |
|
Hours |
|
Learning activities | Altro |
Area | Tirocini formativi e di orientamento |
Academic discipline | MED/09 |
Type of study-unit | Obbligatorio (Required) |
Language of instruction | Italian |
Contents | Professionalising Training in Diseases of the Immune System |
Reference texts | HARRISON " MEDICINE INTERNAL" |
Educational objectives | The results of the learning are based on the verification of acquired ability,on the verification of knowledge from a clinical and diagnostic point of view of the main infectious complications caused by Immunodeficiency States. |
Prerequisites | It is mandatory that students already passed the exams of physiology and general pathology to allow a global comprehension of the topics included in the training. |
Teaching methods | Departmental activities frequency |
Extended program | The training program provides the stake amount to clinical activity, with the specialist, in the unit allogeneic marrow transplantation, and gives you a nearly complete vision of infectious complications caused by Immunodeficiency States. |
PROFESSIONALISING TRAINING IN MOLECULAR MEDICINE
Code | GP004625 |
---|---|
Location | PERUGIA |
CFU | 1 |
Teacher | Cristina Mecucci |
Teachers |
|
Hours |
|
Learning activities | Altro |
Area | Tirocini formativi e di orientamento |
Academic discipline | MED/15 |
Type of study-unit | Obbligatorio (Required) |
PROFESSIONALISING TRAINING IN REUMATHOLOGY
Code | GP005659 |
---|---|
Location | PERUGIA |
CFU | 1 |
Teacher | Roberto Gerli |
Teachers |
|
Hours |
|
Learning activities | Altro |
Area | Tirocini formativi e di orientamento |
Academic discipline | MED/16 |
Type of study-unit | Obbligatorio (Required) |
Language of instruction | Italian |
Contents | Clinical activity with Rheumatologist, included clinical history, physical examination, diagnosis and therapeutic prescription; infusion of biotechnological agents; instrumental diagnosis by ultrasound evaluation of muscle-skeletal areas and ultrasound-driven interventions for joints, tendons, ...; diagnosis of microcirculation disorders by capillaroscopic examination; evaluations of foot and posture disorders. |
Reference texts | UNIREUMA-REUMATOLOGIA per studenti e Medici di Medicina Generale, EDIZIONI IDELSON-GNOCCHI III Ed. 2018. HARRISON et al. Principles of Internal Medicin 19th McGraw Hill Edizione XIX, 2016 |
Educational objectives | Results based on check of the acquired ability, behavior and interaction degree of the student. |
Teaching methods | Partecipation to the above described activities |