Unit PHARMACOLOGY

PHARMACOLOGY - MOD. 1

Code	GP004687
Location	PERUGIA
CFU	2
Teacher	Graziella Migliorati
Teachers	Graziella Migliorati
Hours	24 ore - Graziella Migliorati
Learning activities	Caratterizzante
Area	Farmacologia, tossicologia e principi di terapia medica
Academic discipline	BIO/14
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	General principles Pharmacokinetics Pharmacodynamics Molecular mechanisms of drug action
Reference texts	Recommended reading: - F. Rossi, V. Cuomo, C. Riccardi, Pharmacology: Basic principles and therapeutic applications, Third Edition, published by Minerva Medica - Katzung, general and clinical pharmacology, Piccin, Seventh Edition Italian - F. Clementi, G. Fumagalli, General and Molecular Pharmacology, Third Edition, UTET Reference books: A. Goodman & Gilman, The pharmacological basis of therapy, eleventh edition, McGraw Hill
Educational objectives	At the end of the course students will have learned the pharmacodynamics, pharmacokinetics, undesirable side effects, toxicological aspects, the therapeutic foundations and methods of administration of drugs most important in medical practice. Should be aware of the factors that influence the pharmacological effect and / or therapeutic, as well as the risk / benefit ratio of drug therapy. Must know how to make a reasoned choice of drugs in relation to different pathological situations.
Prerequisites	In order to achieve the intended learning outcomes, the student must have a solid background in anatomy, physiology and general pathology. The student must have already passed the other exams considered as preparatory by the Academic Regulations.
Teaching methods	lessons face-to-face Mandatory attendence
Learning verification modality	Written exam and oral exam The test focuses globally on the entire program. The test consists of 62 multiple choice quiz with five possible answers of which only one is correct; The exam duration time is 1 hour and 15 minutes. For the evaluation of the test takes into account the following criteria: - 0.5 points for each correct answer; - Less than 0.1 points for each wrong answer; - 0 points for each question not answered; The written exam is passed if is obtained a score of at least 18/30. The oral test is mandatory, concerns topics of the entire program and is primarily designed to evaluate the ability to apply their knowledge for the proper use of the drugs in clinical practice. Final vote accounts for 40% of the vote overall written test and 60% vote of the oral test.
Extended program	General principles Origin and Drug Classification Pharmacokinetics Routes of administration Absorption, bioavailability Distribution Metabolism Elimination Main pharmacokinetic parameters: volume of distribution, half-life, clearance Pharmacokinetics quantitative kinetics of zero order and first order Clinical pharmacokinetics, kinetics of the drug administered in repeated doses, the concept of steady state Pharmacodynamics Drug-drug interaction recetthours Agonists, antagonists, partial agonists and inverse Dose-response curves and curves quantal Affinity, potency, efficacy, therapeutic index Molecular structure of receptors Mechanisms of signal transduction Regulation of receptor response Mechanism of action of drugs and correlation between concentration and pharmacological effect of drugs

PHARMACOLOGY - MOD. 2

Code	GP004688
Location	PERUGIA
CFU	2
Teacher	Graziella Migliorati
Teachers	Graziella Migliorati
Hours	24 ore - Graziella Migliorati
Learning activities	Caratterizzante
Area	Farmacologia, tossicologia e principi di terapia medica
Academic discipline	BIO/14
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Principles of clinical pharmacology and therapy Drugs acting at synaptic and neuroeffector junctions
Reference texts	Recommended reading: - F. Rossi, V. Cuomo, C. Riccardi, Pharmacology: Basic principles and therapeutic applications, Third Edition, published by Minerva Medica - Katzung, general and clinical pharmacology, Piccin, Seventh Edition Italian - F. Clementi, G. Fumagalli, General and Molecular Pharmacology, Third Edition, UTET Reference books: A. Goodman & Gilman, The pharmacological basis of therapy, eleventh edition, McGraw Hill
Educational objectives	At the end of the course students will have learned the pharmacodynamics, pharmacokinetics, undesirable side effects, toxicological aspects, the therapeutic foundations and methods of administration of drugs most important in medical practice. Should be aware of the factors that influence the pharmacological effect and / or therapeutic, as well as the risk / benefit ratio of drug therapy. Must know how to make a reasoned choice of drugs in relation to different pathological situations.
Prerequisites	In order to achieve the intended learning outcomes, the student must have a solid background in anatomy, physiology and general pathology. The student must have already passed the other exams considered as preparatory by the Academic Regulations.
Teaching methods	lessons face-to-face Mandatory attendence
Learning verification modality	Written exam and oral exam The test focuses globally on the entire program. The test consists of 62 multiple choice quiz with five possible answers of which only one is correct; The exam duration time is 1 hour and 15 minutes. For the evaluation of the test takes into account the following criteria: - 0.5 points for each correct answer; - Less than 0.1 points for each wrong answer; - 0 points for each question not answered; The written exam is passed if is obtained a score of at least 18/30. The oral test is mandatory, concerns topics of the entire program and is primarily designed to evaluate the ability to apply their knowledge for the proper use of the drugs in clinical practice. Final vote accounts for 40% of the vote overall written test and 60% vote of the oral test.
Extended program	Principles of clinical pharmacology and therapy Adverse drug reaction Variability in individual response to drugs: pharmacokinetic and pharmacodynamic variables, tolerance Pharmacogenetics Drug interactions Drugs acting at synaptic and neuroeffector junctions Neurohumoral transmission: the autonomic and somatic motor Cholinergic Agonists Anticholinesterases Muscarinic antagonists Drugs acting on the neuromuscular junction and autonomic ganglia Catecholamines and sympathomimetic drugs Adrenergic neuron antagonist

PHARMACOLOGY - MOD.3

Code	GP004689
Location	PERUGIA
CFU	2
Teacher	Graziella Migliorati
Teachers	Graziella Migliorati
Hours	24 ore - Graziella Migliorati
Learning activities	Caratterizzante
Area	Farmacologia, tossicologia e principi di terapia medica
Academic discipline	BIO/14
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Cardiovascular system drugs
Reference texts	Recommended reading: - F. Rossi, V. Cuomo, C. Riccardi, Pharmacology: Basic principles and therapeutic applications, Third Edition, published by Minerva Medica - Katzung, general and clinical pharmacology, Piccin, Seventh Edition Italian - F. Clementi, G. Fumagalli, General and Molecular Pharmacology, Third Edition, UTET Reference books: A. Goodman & Gilman, The pharmacological basis of therapy, eleventh edition, McGraw Hill
Educational objectives	At the end of the course students will have learned the pharmacodynamics, pharmacokinetics, undesirable side effects, toxicological aspects, the therapeutic foundations and methods of administration of drugs most important in medical practice. Should be aware of the factors that influence the pharmacological effect and / or therapeutic, as well as the risk / benefit ratio of drug therapy. Must know how to make a reasoned choice of drugs in relation to different pathological situations.
Prerequisites	In order to achieve the intended learning outcomes, the student must have a solid background in anatomy, physiology and general pathology. The student must have already passed the other exams considered as preparatory by the Academic Regulations
Teaching methods	lessons face-to-face Mandatory attendence
Learning verification modality	Written exam and oral exam The test focuses globally on the entire program. The test consists of 62 multiple choice quiz with five possible answers of which only one is correct; The exam duration time is 1 hour and 15 minutes. For the evaluation of the test takes into account the following criteria: - 0.5 points for each correct answer; - Less than 0.1 points for each wrong answer; - 0 points for each question not answered; The written exam is passed if for each test is obtained a score of at least 18/30. The oral test is mandatory, concerns topics of the entire program and is primarily designed to evaluate the ability to apply their knowledge for the proper use of the drugs in clinical practice. Final vote accounts for 40% of the vote overall written test and 60% vote of the oral test.
Extended program	Cardiovascular system drugs Drugs that affect renal function and electrolyte metabolism Pharmacological control of the renin-angiotensin-aldosterone Antihypertensive drugs Antianginal drugs Cardiac glycosides Antiarrhythmic drugs Drugs for treatment of dyslipidemia

PHARMACOLOGY - MOD. 4

Code	GP004690
Location	PERUGIA
CFU	3
Teacher	Graziella Migliorati
Teachers	Graziella Migliorati
Hours	36 ore - Graziella Migliorati
Learning activities	Caratterizzante
Area	Farmacologia, tossicologia e principi di terapia medica
Academic discipline	BIO/14
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Drugs acting on the central nervous system Autacoids and anti-inflammatory drugs Drugs that affect gastrointestinal function Pharmacology of the immune system Drugs acting on blood and blood-forming organs Toxicology Principles of pharmacoeconomics
Reference texts	Recommended reading: - F. Rossi, V. Cuomo, C. Riccardi, Pharmacology: Basic principles and therapeutic applications, Third Edition, published by Minerva Medica - Katzung, general and clinical pharmacology, Piccin, Seventh Edition Italian - F. Clementi, G. Fumagalli, General and Molecular Pharmacology, Third Edition, UTET Reference books: A. Goodman & Gilman, The pharmacological basis of therapy, eleventh edition, McGraw Hill
Educational objectives	At the end of the course students will have learned the pharmacodynamics, pharmacokinetics, undesirable side effects, toxicological aspects, the therapeutic foundations and methods of administration of drugs most important in medical practice. Should be aware of the factors that influence the pharmacological effect and / or therapeutic, as well as the risk / benefit ratio of drug therapy. Must know how to make a reasoned choice of drugs in relation to different pathological situations.
Prerequisites	In order to achieve the intended learning outcomes, the student must have a solid background in anatomy, physiology and general pathology. The student must have already passed the other exams considered as preparatory by the Academic Regulations
Teaching methods	lessons face-to-face Mandatory attendence
Learning verification modality	Written exam and oral exam The test focuses globally on the entire program. The test consists of 62 multiple choice quiz with five possible answers of which only one is correct; The exam duration time is 1 hour and 15 minutes. For the evaluation of the test takes into account the following criteria: - 0.5 points for each correct answer; - Less than 0.1 points for each wrong answer; - 0 points for each question not answered; The written exam is passed if for each test is obtained a score of at least 18/30. The oral test is mandatory, concerns topics of the entire program and is primarily designed to evaluate the ability to apply their knowledge for the proper use of the drugs in clinical practice. Final vote accounts for 40% of the vote overall written test and 60% vote of the oral test.
Extended program	Drugs acting on the central nervous system Neurotransmission and the central nervous system Anxiolytics and sedative-hypnotics Drugs of Affective Disorders, antipsychotics, antidepressants Drugs for the treatment of migraine and the control of vomiting Autacoids and anti-inflammatory drugs General information on inflammation and mediators involved Histamine and antihistamines Non-steroidal anti-inflammatory drugs, drugs used in the treatment of rheumatoid arthritis and gout Steroidal anti-inflammatory drugs Drugs used to treat asthma Drugs that affect gastrointestinal function Antiulcer drugs Drugs that affect gastrointestinal motility Pharmacology of the immune system Serums and Vaccines Immunosuppressants and immunostimulants Drugs acting on blood and blood-forming organs Emopietici agents: growth factors and vitamins Anticoagulants, thrombolytics, and antiplatelet Toxicology Principles of Toxicology Mechanisms of toxicity Fetotoxicity Abuse, Drug Addiction Rational basis of treatment of drug addiction Principles of pharmacoeconomics

PHARMACOLOGY - MOD. 5

Code	GP004691
Location	PERUGIA
CFU	3
Teacher	Graziella Migliorati
Teachers	Graziella Migliorati
Hours	36 ore - Graziella Migliorati
Learning activities	Caratterizzante
Area	Formazione clinica interdisciplinare e medicina basata sulle evidenze
Academic discipline	BIO/14
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Drugs acting on the central nervous system Endocrine Drugs Drugs affecting uterine motility Chemotherapy Pharmacological trials, pharmacovigilance
Reference texts	Recommended reading: - F. Rossi, V. Cuomo, C. Riccardi, Pharmacology: Basic principles and therapeutic applications, Third Edition, published by Minerva Medica - Katzung, general and clinical pharmacology, Piccin, Seventh Edition Italian - F. Clementi, G. Fumagalli, General and Molecular Pharmacology, Third Edition, UTET Reference books: A. Goodman & Gilman, The pharmacological basis of therapy, eleventh edition, McGraw Hill
Educational objectives	At the end of the course students will have learned the pharmacodynamics, pharmacokinetics, undesirable side effects, toxicological aspects, the therapeutic foundations and methods of administration of drugs most important in medical practice. Should be aware of the factors that influence the pharmacological effect and / or therapeutic, as well as the risk / benefit ratio of drug therapy. Must know how to make a reasoned choice of drugs in relation to different pathological situations.
Prerequisites	In order to achieve the intended learning outcomes, the student must have a solid background in anatomy, physiology and general pathology. The student must have already passed the other exams considered as preparatory by the Academic Regulations.
Teaching methods	lessons face-to-face Mandatory attendence
Learning verification modality	Written exam and oral exam The test focuses globally on the entire program. The test consists of 62 multiple choice quiz with five possible answers of which only one is correct; The exam duration time is 1 hour and 15 minutes. For the evaluation of the test takes into account the following criteria: - 0.5 points for each correct answer; - Less than 0.1 points for each wrong answer; - 0 points for each question not answered; The written exam is passed if is obtained a score of at least 18/30. The oral test is mandatory, concerns topics of the entire program and is primarily designed to evaluate the ability to apply their knowledge for the proper use of the drugs in clinical practice. Final vote accounts for 40% of the vote overall written test and 60% vote of the oral test.
Extended program	Drugs acting on the central nervous system General Anesthetics Anticonvulsants Drugs for treatment of neurodegenerative diseases Endocrine Drugs Thyroid and Antithyroid Estrogens, progestins, birth control Androgens and anabolic steroids Insulin and oral hypoglycemic Drugs affecting uterine motility Chemotherapy General principles Antibacterial chemotherapy: Drugs inhibiting cell wall synthesis Drugs inhibiting protein synthesis Fluoroquinolones Sulfonamides and trimethoprim Metronidazole Anti-tuberculosis Antiprotozoal chemotherapy Antiviral chemotherapy Antifungal chemotherapy Antineoplastic chemotherapy Pharmacological trials, pharmacovigilance

PHARMACOLOGY - MOD. 6

Code	GP004692
Location	PERUGIA
CFU	1
Teacher	Domenico Vittorio Delfino
Teachers	Domenico Vittorio Delfino
Hours	12 ore - Domenico Vittorio Delfino
Learning activities	Affine/integrativa
Area	Attività formative affini o integrative
Academic discipline	BIO/14
Type of study-unit	Obbligatorio (Required)