Unit CLINICAL SCIENCES

HAEMATOLOGY

Code	50018202
CFU	2
Teachers	Paolo Sportoletti (Codocenza)
Hours	24 ore (Codocenza) - Paolo Sportoletti
Learning activities	Caratterizzante
Area	Scienze interdisciplinari cliniche
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	The module in question is intended to bring to the attention of the student the most important hematologic disorders, new diagnostic tests and their correlation with specific diseases. Provides the necessary elements in order to interpret the meaning of changes in the main laboratory tests
Reference texts	MALATTIE DEL SANGUE E DEGLI ORGANI EMOLINFOPOIETICI- Sante Tura - Editrice ESCULAPIO
Educational objectives	It aims to raise awareness and understanding of the student the meaning of laboratory tests for the purpose of major diseases. In particular, it aims to make early detection of diseases that may emerge from the evaluation of the laboratory tests at the end of the course the student should be able to use the acquired knowledge to identify the most common hematologic diseases
Prerequisites
Teaching methods	Lectures with presentation of reports and case studies that will give students the chance to meet with real cases in order to learn to be inferred from laboratory data sottese diseases and problems related to them.
Other information
Learning verification modality	The learning and the degree of preparation is checked by written examination concerning the arguments discussed during the lessons. The students must demonstrate that they have acquired adequate knowledge and skills to recognize the main hematological diseases and related alterations of laboratory tests.
Extended program	1) Hematopoiesis: concepts of general biology and laboratory techniques related to the identification and study of hematopoietic stem cells normal and pathological conditions. 2) leukemogenesis: general overview and pathogenetic mechanisms: laboratory tests related to diagnosis, prognosis, response to treatment and monitoring over time. 3) acute myeloid leukemia and acute leukemias LYMPHOID: generali. Esami concepts inherent laboratory diagnosis, prognosis, response to treatment and monitoring over time. 4) lymphoproliferative syndromes CHRONIC: general overview and differential diagnosis between the various lymphoproliferative diseases 5) chronic myeloproliferative disorders: general overview and differential diagnosis between the various myeloproliferative diseases

OCCUPATIONAL MEDICINE

Code	50788102
CFU	2
Teacher	Giacomo Muzi
Teachers	Giacomo Muzi
Hours	24 ore - Giacomo Muzi
Learning activities	Caratterizzante
Area	Scienze della prevenzione e dei servizi sanitari
Academic discipline	MED/44
Type of study-unit	Obbligatorio (Required)

LEGAL MEDICINE

Code	50667601
CFU	1
Teachers	Laura Paglicci Reattelli (Codocenza)
Hours	12 ore (Codocenza) - Laura Paglicci Reattelli
Learning activities	Caratterizzante
Area	Scienze della prevenzione e dei servizi sanitari
Academic discipline	MED/43
Type of study-unit	Obbligatorio (Required)

MEDICAL ONCOLOGY

Code	50667701
CFU	1
Teachers	Giulio Metro (Codocenza)
Hours	12 ore (Codocenza) - Giulio Metro
Learning activities	Caratterizzante
Area	Scienze interdisciplinari cliniche
Academic discipline	MED/06
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Factors predicting response to targeted therapies in colon cancer, breast cancer, lung cancer, gastrointestinal stromal tumor; concepts of immunotherapy; techniques used for the detection of genetic mutations that predict sensitivity to treatment performed on tumor tissue and plasma
Reference texts	Teaching material provided by the professor
Educational objectives	In the precision era medicine, in view of the personalization of cancer treatment, this course aims at providing the student with knowledge on the rationale behind the main techniques of molecular biology for solid tumors, as well as on the skills required to perform them
Prerequisites	Those required by the study plan
Teaching methods	Taught class
Other information	Practical exercise of 4 hours at the laboratory of Medical Oncology
Learning verification modality	Written exam consisting of 12 multiple choice quizzes and one open-ended question
Extended program	Principles of epidemiology and carcinogenesis; chemotherapy and mechanism of action; intracellular signaling pathways; targeted therapy and classification (monoclonal antibodies, antibodies-drug conjugates, small molecules tyrosine kinase inhibitors); colon cancer, role of RAS and BRAF mutations in colon cancer, anti-EGFR therapies in colon cancer; breast cancer and its subtypes, HER2-positive breast cancer, methods for HER2 assessment, anti-HER2 therapies; non-small cell lung cancer, molecular subtyped of adenocarcinoma of the lung, EGFR, ALK, ROS1 mutations and other minor genetic drivers in lung adenocarcinoma; melanoma, BRAF mutation and sensitivity to BRAF inhibitors +/- MEK inhibitors; gastrointestinal stromal tumors, C-KIT mutation and sensitivity to imatinib; immunotherapy and its application in the treatment of solid tumors; markers of sensitivity to immunotherapy, PD-L1 and TMB; main techniques of genetic sequencing aimed at measuring predictive mutations on tumor tissue, with a focus on next-generation sequencing (NGS); liquid biopsy and its application in solid tumors, with a focus on lung cancer; techniques for performing a liquid biopsy (real time PCR, digital PCR, NGS)