Unit PHARMACOLOGICAL SCIENCES

DRUG TOXICOLOGY

Code	50667201
CFU	1
Teacher	Simona Ronchetti
Teachers	Simona Ronchetti
Hours	12 ore - Simona Ronchetti
Learning activities	Base
Area	Primo soccorso
Academic discipline	BIO/14
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Toxicology: general principlesDrug adverse reactionsantidotesdrug-drug interaction, drug-food interactionspre-clinical and clinical trials
Reference texts	- F. Rossi, V. Cuomo, C. Riccardi, Farmacologia: principi di base e applicazioni terapeutiche, III Edizione, Edizioni Minerva Medica ¿- Rang, Dale, Ritter, Flower. Farmacologia-C.L. Galli, E. Corsini, M. Marinovich, Tossicologia, Piccin
Educational objectives	The course will allow the student to acquire knowledge about the adverse and toxic effects, as well as the therapeutic bases and the administration route of the most important drugs. The student will be aware of those factors that influence the desired pharmacological and undesired toxicologic effects.
Prerequisites	none requested
Teaching methods	face-to-face lessons
Other information	compulsory course attendance
Learning verification modality	written exam, multiple choice
Extended program	Toxicology: general principles, dose-toxic effect relationship, toxicity curves, organ toxicitydrug adverse reactions: classification and examplesantidotes: the most important for poisoningdrug-drug interaction, drug-food interactionspre-clinical and clinical trials

GENERAL PHARMACOLOGY

Code	50555502
CFU	2
Teachers	Giada Mondanelli (Codocenza)
Hours	24 ore (Codocenza) - Giada Mondanelli
Learning activities	Base
Area	Primo soccorso
Academic discipline	BIO/14
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Definition of drug. Definition of primary and side effects of drug. Pharmacokinetics: description of absorption, distribution, metabolism and elimination of drugs. Pharmacodynamics: definition of the concept of receptor, classes of receptors and signal transduction mechanisms. Clinical pharmacology aspects.
Reference texts	R. Paoletti, S. Nicosia, F Clementi, G. Fumagalli Farmacologia generale e molecolare, EDRA.
Educational objectives	The main knowledge acquired during the course will relate to: 1) absorption, distribution, metabolism and elimination of drugs 2) routes of administration 3) bioavailability and bioequivalence 4) drug receptors 5) receptor activation theories 6) signal transduction mechanisms 7) toxic effects The knowledge acquired will allow the student to achieve the following skills: 1) calculate the correct dosage of a drug 2) understand the mechanism of action of a drug 3) understand the relevance of the dose-effect concept 4) use drugs rationally and achieve maximum effectiveness with minimum toxicity
Prerequisites	In order to achieve the expected outcomes, the student must have basic knowledge of anatomy, physiology and general pathology. It must also respect the prerequisites envisaged.
Teaching methods	The course consists of classroom lectures on all topics of the course.
Other information	The student can contact the teacher using the following email address: giada.mondanelli@unipg.it
Learning verification modality	The exam includes a written test (multiple choice questions) at the end of the course
Extended program	GENERAL PHARMACOLOGY. Definition of drug. Traditional drug characteristics. Definition of biotechnological drugs. Primary and side effects. General pharmacokinetics: passages of drugs across cell membranes; routes of administration and absorption; bioavailability; distribution of drugs in the body; volume of distribution, binding to plasma proteins; drug metabolism; excretion; time-course of drug plasmatic contents (after single or repeated administration). General pharmacodynamics: targets and mechanisms of drug action; receptors, classification of membrane receptors, intracellular receptors, dose-response curve; agonists, partial agonists, antagonists; individual variations (effects of age, pathological states, drug interactions, tolerance, placebo effects).

METHODS AND TECHNIQUES OF PHARMACOLOGY AND TOXICOLOGY

Code	50667901
CFU	1
Teachers	Marilena Micheli (Codocenza)
Hours	16 ore (Codocenza) - Marilena Micheli
Learning activities	Caratterizzante
Area	Scienze e tecniche di laboratorio biomedico
Academic discipline	MED/46
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Analysis of the role of hospital pharmacy, sterile galenic laboratory (chemotherapy preparations and parenteral nutrition) and non-sterile galenic laboratory
Reference texts	Slides and other material provided by the teacher
Educational objectives	Knowledge of galenic preparation methods and master and officinal chemotherapy, knowledge of appropriate work behavior and safety within the hospital pharmacy
Prerequisites	Knowledge of the concept of sterility and knowledge of personal protective equipment (DPI)
Teaching methods	Theoretical lessons and practical exercises in sterile and non-sterile galenic laboratory
Other information	E-mail of the teacher: marilenamicheli@ibero.it Structure: clinical galenic
Learning verification modality	Written test with multiple choice
Extended program	- Sterile and non-sterile galenic, preparatory procedures, relative standards and instruments -Good preparation standards, PPE - Preparation of antineoplastic drugs and process methodologies - Preparation of parenteral nutrition bags and process automation -Training course of the biomedical laboratory health technician in the hospital pharmacy -Acquisition of theoretical principles and working techniques in hospital pharmacy