Unit GENERAL BIOLOGY AND GENETICS

GENERAL BIOLOGY AND GENETICS - MOD. 1

Code	GP004753
Location	TERNI
CFU	3
Teacher	Maria Laura Belladonna
Teachers	Maria Laura Belladonna
Hours	36 ore - Maria Laura Belladonna
Learning activities	Base
Area	Discipline generali per la formazione del medico
Academic discipline	BIO/13
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Cell organization of living organisms. Chemical components of the cell. Prokaryotic and eukaryotic cells. The eukaryotic cell components: cell membrane, mitochondria, endomembrane system. Cell communication: membrane receptors and signal transduction.
Reference texts	Becker "IL MONDO DELLA CELLULA" Ed. Pearson – 8th edition Solomon et al. "FONDAMENTI DI BIOLOGIA" Ed. EdiSES – 7th edition
Educational objectives	The main objective of the module is the integrated study of animal cell, with particular regard to mechanisms involved in the biogenesis of organels and cell structures, in cell-cell and cell-environment interactions, and bioenergetics. Students should acquire the ability to connect different cellular processes and apply the acquired knowledge to understand the following teachings.
Prerequisites	To effectively follow and understand the topics covered in the course of General Biology and Genetics is necessary for the student to have a basic knowledge of Chemistry and Biology as it is normally acquired in high school. In particular, basic knowledge should be relative to cell structure, atom structure, chemical bonds, simple inorganic and organic molecules.
Teaching methods	Face-to-face and practical training.
Learning verification modality	The exam consists of a written and/or an oral exam. Written exam is a multiple choice test on all the topics covered in the course, lasting 60 minutes. The aim of the written exam is verifying the basic level of knowledge necessary to access to oral examination. The oral examination lasts not longer than 30 minutes and enables to verify the level of knowledge and understanding achieved by the student; the ability of the student to highlight the correlations between the various biological processes. In addition, the oral examination will assess the student's ability to communicate and expose with appropriate language the topics of the cell biology. The exam will be performed at the end of the course according to the exam timetable. The evaluation will be in thirtieths (minimum: 18/30; maximum: 30/30 cum laude)
Extended program	Cell organization of living organisms. Chemical components of the cell: water and macromolecules (proteins, nucleic acids, polysaccharides and lipids). Prokaryotic and eukaryotic cells, viruses and prions. Bioenergetics. Enzymes. The eukaryotic cell components: cell membrane (composition and structure, permeability, ion and molecule transport); mitochondria and chemotrophic energy metabolism; endomembrane system (endoplasmic reticulum, Golgi apparatus, lysosome; vesicular transport, exocytosis and endocytosis); peroxisome. Cell communication: electric signals, chemical signals, membrane receptors and signal transduction.

GENERAL BIOLOGY AND GENETICS - MOD. 2

Code	GP004754
Location	TERNI
CFU	3
Teacher	Maria Laura Belladonna
Teachers	Maria Laura Belladonna
Hours	36 ore - Maria Laura Belladonna
Learning activities	Base
Area	Discipline generali per la formazione del medico
Academic discipline	BIO/13
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Eukaryotic cell components: cytoskeleton and nucleus. Cell adhesion mechanisms. DNA replication and cell cycle. Asexual and sexual reproduction. Transcription and protein synthesis. Regulation of gene expression. Tumor cells.
Reference texts	Becker "IL MONDO DELLA CELLULA" Ed. Pearson – 8th edition Solomon et al. "FONDAMENTI DI BIOLOGIA" Ed. EdiSES – 7th edition
Educational objectives	The main objective of the module is the integrated study of animal cell, with particular regard to mechanisms involved in gene expression process and its regulation, duplication and transmission of genetic information, cell proliferation, and basic elements of recombinant DNA technology. Students should acquire the ability to connect different cellular processes and apply the acquired knowledge to understand the following teachings.
Prerequisites	To effectively follow and understand the topics covered in the course of General Biology and Genetics is necessary for the student to have a basic knowledge of Chemistry and Biology as it is normally acquired in high school. In particular, basic knowledge should be relative to cell structure, atom structure, chemical bonds, simple inorganic and organic molecules.
Teaching methods	Face-to-face and practical training
Learning verification modality	The exam consists of a written and/or an oral exam. Written exam is a multiple choice test on all the topics covered in the course, lasting 60 minutes. The aim of the written exam is verifying the basic level of knowledge necessary to access to oral examination. The oral examination lasts not longer than 30 minutes and enables to verify the level of knowledge and understanding achieved by the student; the ability of the student to highlight the correlations between the various biological processes. In addition, the oral examination will assess the student's ability to communicate and expose with appropriate language the topics of the cell biology. The exam will be performed at the end of the course according to the exam timetable. The evaluation will be in thirtieths (minimum: 18/30; maximum: 30/30 cum laude)
Extended program	Eukaryotic cell components: Cytoskeleton (microtubules, microfilaments and intermediate filament), nucleus (chromatin, chromosomes, nucleolus). Cell adhesion mechanisms. Genetic information and gene expression. Genes and genome in prokaryotes and eukaryotes. DNA replication. Cell cycle phases and control. Apoptosis. Asexual and sexual reproduction. Meiosis. Gene recombination. Gametogenesis and fertilization. Karyotype. Gene, chromosome and genome mutations. Transcription. RNA maturation. Messenger RNA. Transfer RNA. Ribosomal RNA and ribosomes. Genetic code and translation of gene information: protein synthesis. Regulation of gene expression in prokaryotes: bacterial operon. Regulation of gene expression in eukaryotes at transcriptional and post-transcriptional level. Tumor cells.

GENERAL BIOLOGY AND GENETICS - MOD. 3

Code	GP004755
Location	TERNI
CFU	1
Teacher	Maria Laura Belladonna
Teachers	Maria Laura Belladonna
Hours	12 ore - Maria Laura Belladonna
Learning activities	Base
Area	Discipline generali per la formazione del medico
Academic discipline	BIO/13
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Principles of general and human genetics.
Reference texts	Becker "IL MONDO DELLA CELLULA" Ed. Pearson – 8th edition Solomon et al. "FONDAMENTI DI BIOLOGIA" Ed. EdiSES – 7th edition
Educational objectives	The main objective of the module is the integrated study of animal cell, with particular regard to transmission of genetic information, and principles of general and human genetics. Students should acquire the ability to connect different cellular processes and apply the acquired knowledge to understand the following teachings.
Prerequisites	To effectively follow and understand the topics covered in the course of General Biology and Genetics is necessary for the student to have a basic knowledge of Chemistry and Biology as it is normally acquired in high school. In particular, basic knowledge should be relative to cell structure, atom structure, chemical bonds, simple inorganic and organic molecules.
Teaching methods	Face-to-face and practical training
Learning verification modality	The exam consists of a written and/or an oral exam. Written exam is a multiple choice test on all the topics covered in the course, lasting 60 minutes. The aim of the written exam is verifying the basic level of knowledge necessary to access to oral examination. The oral examination lasts not longer than 30 minutes and enables to verify the level of knowledge and understanding achieved by the student; the ability of the student to highlight the correlations between the various biological processes. In addition, the oral examination will assess the student's ability to communicate and expose with appropriate language the topics of the cell biology. The exam will be performed at the end of the course according to the exam timetable. The evaluation will be in thirtieths (minimum: 18/30; maximum: 30/30 cum laude)
Extended program	Principles of general and human genetics. Mendel's Laws. Incomplete dominance and codominance. Multiple alleles. Pleiotropy. Gene interaction. Quantitative traits. Continuous and discontinuous variation. Normal and pathologic human karyotypes. Mendel's inheritance in humans. Genetic pedigrees (Family trees). Dominant and recessive autosomal heredity, sex linkage.