Unit CHEMISTRY AND BIOCHEMISTRY I
- Course
- Medicine and surgery
- Study-unit Code
- GP004730
- Location
- TERNI
- Curriculum
- In all curricula
- Teacher
- Alba Vecchini
- CFU
- 11
- Course Regulation
- Coorte 2017
- Offered
- 2017/18
- Type of study-unit
- Obbligatorio (Required)
- Type of learning activities
- Attività formativa integrata
BIOCHEMISTRY I - MOD. 1
Code | GP004762 |
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Location | TERNI |
CFU | 3 |
Teacher | Alba Vecchini |
Teachers |
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Hours |
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Learning activities | Base |
Area | Struttura, funzione e metabolismo delle molecole d'interesse biologico |
Academic discipline | BIO/10 |
Type of study-unit | Obbligatorio (Required) |
Language of instruction | Italian |
Contents | Structural biochemistry: carbohydrates, lipids, nucleotides, nucleic acids, amino acids, proteins. Hemoglobin and myoglobin |
Reference texts | Biochimica Medica - Silibrandi, Tettamanti - Piccin Editore I Principi della biochimica di Lehninger - Nelson, Cos. V edizione - Zanichelli Biochimica con aspetti clinici Devlin /5e - Edises |
Educational objectives | STRUCTURE, FUNCTION AND METABOLISM OF MOLECULES OF BIOLOGICAL INTEREST |
Prerequisites | Fundamental principles of general chemistry and main functional groups of organic chemistry |
Teaching methods | Lessons |
Other information | Compulsory attendance for 75% of the lessons |
Learning verification modality | Pratical test and oral exam |
Extended program | Structure and chemical properties of biological compounds Carbohydrates: monosaccharides and disaccharides. Omopolisaccharides (cellulose, starch and glycogen). heteropolysaccharides (hyaluronic acid, chondroitin sulfate, dermatan sulfate, keratan, heparin). Lipids: fatty acids, acylglycerols, phospholipids. Cholesterol. Nucleosides, nucleotides and nucleic acids. Proteins: Structure and properties of amino acids. Peptide bond. Structural organization of proteins. Denaturation. Outline of analytical techniques for the separation and balance of proteins. Globular proteins. Fibrous proteins (collagen, keratin and elastin). Physical-chemical properties of proteins. Immunoglobulins and conjugated proteins. Myoglobin (structure and function). Hemoglobin (structure and function). Molecular mechanism of oxygen transport. Factors that alter the affinity of hemoglobin for oxygen. Molecular and functional mechanism of the action of Hb buffer. role in the transport of Hb direct and indirect carbon dioxide. Types of hemoglobin and glycated hemoglobin |
BIOCHEMISTRY I - MOD. 2
Code | GP004764 |
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Location | TERNI |
CFU | 3 |
Teacher | Alba Vecchini |
Teachers |
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Hours |
|
Learning activities | Base |
Area | Struttura, funzione e metabolismo delle molecole d'interesse biologico |
Academic discipline | BIO/10 |
Type of study-unit | Obbligatorio (Required) |
Language of instruction | Italian |
Contents | STRUCTURE, FUNCTION AND METABOLISM OF MOLECULES OF BIOLOGICAL INTEREST |
Reference texts | Biochimica Medica - Silibrandi, Tettamanti - Piccin Editore I Principi della biochimica di Lehninger - Nelson, Cos. V edizione - Zanichelli Biochimica con aspetti clinici Devlin /5e - Edises |
Educational objectives | Mechanisms of action of enzymes and coenzymes and regulation. Aspects of thermodynamics and bioenergetics in biochemical reactions. cellular oxidation and ATP synthesis |
Prerequisites | Knowledge of the main molecules of biological interest |
Teaching methods | Lessons |
Other information | The attendance is compulsory for 75% |
Learning verification modality | Pratical and oral examination |
Extended program | Enzymes: enzyme catalysis. Active site. Specificity. Nature of the Enzyme and their classification. Enzymes constitutive and inductive. Kinetics of enzymatic reactions. Michaelis-Menten constant and its meaning. Factors affecting the activity of enzymes. Enzyme inhibition. Mechanisms of enzyme inhibition. regulation of enzyme activity. signs of clinical enzymology. Vitamins and coenzymes: food sources of vitamins. Determination of the state of nutrition vitamins in humans. water-soluble vitamins (C, biotin, niacin, thiamin, pantothenic acid, riboflavin, pyridoxine, folate, B12). Fat-soluble vitamins (A, E, K, D). Choline, carnitine, taurine. Coenzymes. Structure and function of biological membranes: membrane composition. structure and properties of membrane lipids. systems of transport through the membrane. structure and function of the Na + / K + ATPase. General aspects of metabolism: catabolism and anabolism. Bioenergetics: the general principles of chemical thermodynamics. Redox potential. links to high energy of hydrolysis. ATP: structure and role in the transfer of energy. Organization of metabolic pathways. the pyruvate dehydrogenase complex. Krebs cycle: metabolic role and regulation. respiratory chain and oxidative phosphorylation. Inhibitors of the respiratory chain and uncoupling agents |
CHEMISTRY - MOD. 1
Code | GP004761 |
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Location | TERNI |
CFU | 3 |
Teacher | Veronica Ceccarelli |
Teachers |
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Hours |
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Learning activities | Base |
Area | Struttura, funzione e metabolismo delle molecole d'interesse biologico |
Academic discipline | BIO/10 |
Type of study-unit | Obbligatorio (Required) |
Language of instruction | Italian |
Contents | The electronic structure and the properties of atoms: the quantum numbers, the atomic orbitals, the electronic configurations of the elementsPeriodic table of the elements and the properties of elements: ionization potential, electron affinity and electronegativityCovalent molecules: the combination of s orbitals, the combination of p orbitals, the formation of diatomic molecules; poliatomic molecules.Chemical bonds: covalent bonds, ionic bonds, idrogen bond, ibridization, Inorganic moleculesSolid state, liquid state and vapor stateSolution chemistryAcids and bases and chemical balancepH measurements of different solutionsPrinciples of thermodynamics, chemical kinetics and oxidation status |
Reference texts | Chimica e Propedeutica Biochimica - Luciano Binaglia e Bruno Giardina |
Educational objectives | The main competence will be to have a general knowledge of inorganic chemistry |
Prerequisites | In order to be able to understand and apply the majority of the contents described within the course, the student must have acquired basic knowledge of chemistry and mathematics studied for access to the Faculty of Medicine. |
Teaching methods | The course is organized with face to face lessons on all subjects of the course using slide projections.Students are stimulated to interact with the teacher during the lectures.Hours available to the students to be established during the course for clarification and insights.During the course you will have an ongoing learning test |
Other information | The attendance is compulsory at least 75% of lessonsTerni - School of Medicine - Educational and Scientific Center |
Learning verification modality | The final exam consists of a pratical test and an oral exam |
Extended program | The electronic structure and the properties of atoms: the quantum numbers, the atomic orbitals, the electronic configurations of the elementsPeriodic table of the elements and the properties of elements: ionization potential, electron affinity and electronegativityCovalent molecules: the combination of s orbitals, the combination of p orbitals, the formation of diatomic molecules; poliatomic molecules.Chemical bonds: covalent bonds, ionic bonds, idrogen bond, ibridization, Inorganic moleculesSolid state, liquid state and vapor stateSolution chemistryAcids and bases and chemical balancepH measurements of different solutionsPrinciples of thermodynamics, chemical kinetics and oxidation status |
CHEMISTRY - MOD. 2
Code | GP004763 |
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Location | TERNI |
CFU | 2 |
Teacher | Veronica Ceccarelli |
Teachers |
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Hours |
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Learning activities | Affine/integrativa |
Area | Attività formative affini o integrative |
Academic discipline | BIO/10 |
Type of study-unit | Obbligatorio (Required) |
Language of instruction | Italian |
Contents | hydrocarbons: alkanes, alkenes, alkines and their characteristic reactionsaromatic hydrocarbons and their characteristic reactionsstereoisomery and enantiomersalcohols, phenols and their characteristic reactionsalkyl halidesaldehydes and ketones and reactions aliphatic and aromatic amines carboxylic acids and their reactions derivatives of carboxylic acidsaromatic heterocycles |
Reference texts | Chimica e Propedeutica Biochimica - Luciano Binaglia e Bruno Giardina |
Educational objectives | The main competence will be to have a general knowledge of organic chemistry in order to approach the study of biochemistry |
Prerequisites | In order to be able to understand and apply the majority of the contents described within the course, the student must have acquired basic knowledge of Inorganic chemistry |
Teaching methods | The course is organized with face to face lessons on all subjects of the course using slide projections.Students are stimulated to interact with the teacher during the lectures.Hours available to the students to be established during the course for clarification and insights.During the course you will have an ongoing learning test |
Other information | The attendance is compulsory at least 75% of lessonsTerni - School of Medicine - Educational and Scientific Center |
Learning verification modality | The final exam consists of a pratical test and an oral exam. |
Extended program | hydrocarbons: alkanes, alkenes, alkines and their characteristic reactionsaromatic hydrocarbons and their characteristic reactionsstereoisomery and enantiomersalcohols, phenols and their characteristic reactionsalkyl halidesaldehydes and ketones and reactions aliphatic and aromatic amines carboxylic acids and their reactions derivatives of carboxylic acidsaromatic heterocycles |