Code |
GP004762 |
Location |
TERNI |
CFU |
3 |
Teacher |
Alba Vecchini |
Teachers |
|
Hours |
|
Learning activities |
Base |
Area |
Struttura, funzione e metabolismo delle molecole d'interesse biologico |
Academic discipline |
BIO/10 |
Type of study-unit |
Obbligatorio (Required) |
Language of instruction |
Italian |
Contents |
Structural biochemistry: carbohydrates, lipids, nucleotides, nucleic acids, amino acids, proteins. Hemoglobin and myoglobin |
Reference texts |
To be defined |
Educational objectives |
The main competence will be to have a general knowledge necessary to address the lessons of Module 2. |
Prerequisites |
The student must have acquired basic knowledge of the main topics of General Chemistry and Organic Chemistry |
Teaching methods |
The course is organized in:-frontal lessons-theoretical practical lessons |
Other information |
The attendance is compulsory at least 75% of lessons.Terni –School of Medicine – Educational and Scientific Center |
Learning verification modality |
The final exam consists of a written test with multiple choice questions and an oral exam |
Extended program |
Structure and chemical properties of biological compounds Carbohydrates: monosaccharides and disaccharides. Omopolisaccharides (cellulose, starch and glycogen). heteropolysaccharides (hyaluronic acid, chondroitin sulfate, dermatan sulfate, keratan, heparin). Lipids: fatty acids, acylglycerols, phospholipids. Cholesterol. Nucleosides, nucleotides and nucleic acids. Proteins: Structure and properties of amino acids. Peptide bond. Structural organization of proteins. Denaturation. Outline of analytical techniques for the separation and balance of proteins. Globular proteins. Fibrous proteins (collagen, keratin and elastin). Physical-chemical properties of proteins. Immunoglobulins and conjugated proteins. Myoglobin (structure and function). Hemoglobin (structure and function). Molecular mechanism of oxygen transport. Factors that alter the affinity of hemoglobin for oxygen. Molecular and functional mechanism of the action of Hb buffer. role in the transport of Hb direct and indirect carbon dioxide. Types of hemoglobin and glycated hemoglobin |
Code |
GP004764 |
Location |
TERNI |
CFU |
3 |
Teacher |
Alba Vecchini |
Teachers |
|
Hours |
|
Learning activities |
Base |
Area |
Struttura, funzione e metabolismo delle molecole d'interesse biologico |
Academic discipline |
BIO/10 |
Type of study-unit |
Obbligatorio (Required) |
Language of instruction |
Italian |
Contents |
The Module 2 program covers the following topics: Enzymes. Coenzyme structure and action mechanism. Catabolism and Anabolism. Bioenergetics. High energy bonds. ATP. Pyruvate dehydrogenase. Cycle do Krebs. Respiratory chain and oxidative phosphorylation |
Reference texts |
To be defined |
Educational objectives |
At the end of the course the student should be in possession of the main knowledge related to Structural Biochemistry, Catabolism and Anabolism and Energy Biochemistry |
Prerequisites |
The student must have acquired basic knowledge of the main topics of General Chemistry and Organic Chemistry and Structural Biochemistry |
Teaching methods |
The course is organized in:-frontal lessons-theoretical practical lessons |
Other information |
The attendance is compulsory at least 75% of lessons.Terni –School of Medicine – Educational and Scientific Center |
Learning verification modality |
The final exam consists of a written test with multiple choice questions and an oral exam |
Extended program |
Enzymes: enzyme catalysis. Active site. Specificity. Nature of the Enzyme and their classification. Enzymes constitutive and inductive. Kinetics of enzymatic reactions. Michaelis-Menten constant and its meaning. Factors affecting the activity of enzymes. Enzyme inhibition. Mechanisms of enzyme inhibition. regulation of enzyme activity. signs of clinical enzymology. Vitamins and coenzymes: food sources of vitamins. Determination of the state of nutrition vitamins in humans. water-soluble vitamins (C, biotin, niacin, thiamin, pantothenic acid, riboflavin, pyridoxine, folate, B12). Fat-soluble vitamins (A, E, K, D). Choline, carnitine, taurine. Coenzymes. Structure and function of biological membranes: membrane composition. structure and properties of membrane lipids. systems of transport through the membrane. structure and function of the Na + / K + ATPase. General aspects of metabolism: catabolism and anabolism. Bioenergetics: the general principles of chemical thermodynamics. Redox potential. links to high energy of hydrolysis. ATP: structure and role in the transfer of energy. Organization of metabolic pathways. the pyruvate dehydrogenase complex. Krebs cycle: metabolic role and regulation. respiratory chain and oxidative phosphorylation. Inhibitors of the respiratory chain and uncoupling agents |