Unit GENERAL PATHOLOGY AND PATHOPHYSIOLOGY 1

GENERAL PATHOLOGY AND PATHOPHYSIOLOGY - MOD. 1

Code	GP004709
Location	TERNI
CFU	6
Teacher	Stefano Brancorsini
Teachers	Stefano Brancorsini
Hours	72 ore - Stefano Brancorsini
Learning activities	Caratterizzante
Area	Patologia generale e molecolare, immunopatologia, fisiopatologia generale, microbiologia e parassitologia
Academic discipline	MED/04
Type of study-unit	Obbligatorio (Required)

GENERAL PATHOLOGY AND PATHOPHYSIOLOGY - MOD. 2

Code	GP004710
Location	TERNI
CFU	1
Teacher	Stefano Brancorsini
Teachers	Stefano Brancorsini
Hours	12 ore - Stefano Brancorsini
Learning activities	Caratterizzante
Area	Patologia generale e molecolare, immunopatologia, fisiopatologia generale, microbiologia e parassitologia
Academic discipline	MED/04
Type of study-unit	Obbligatorio (Required)

GENERAL PATHOLOGY AND PATHOPHYSIOLOGY - MOD. 3

Code	GP004711
Location	TERNI
CFU	1
Teacher	Luigina Romani
Teachers	Luigina Romani
Hours	12 ore - Luigina Romani
Learning activities	Caratterizzante
Area	Patologia generale e molecolare, immunopatologia, fisiopatologia generale, microbiologia e parassitologia
Academic discipline	MED/04
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	IMMUNOPATHOLOGY – The immune reactions as a cause of disease (from type I to type VII): autoimmunity (major systemic and organ diseases and related pathogenic mechanisms); atopic diseases (allergies, asthma, anaphylaxis); autoinflammatory diseases. – Transplant rejection and Graft vs. Host Disease. – Immunology and immunotherapy of cancer: immune response against tumors; tumor antigens; tumor immune-evasion; adoptive and active specific immunotherapy.
Reference texts	Abbas A.K., Lichtman A.H., Pillai S. Immunologia Cellulare e Molecolare. Ottava Edizione, 2015, Elsevier-Saunders Editore. Janeway C.A., Murphy K., Travers P., Walport M. Janeway's Immunobiologia. Ottava edizione, 2014, Piccin Editore.
Educational objectives	At the end of the course, the student must demonstrate knowledge and understanding: – The immune system: purpose, organization and components; Innate and adaptive immunity; system immunology. – Inflammation. Regulation of inflammation: The role of the microbiota. – Antigen processing and presentation; activation of lymphocytes T and B. – Central and peripheral immune tolerance. – Immunological memory. The antimicrobial response. Immunology and cancer immunotherapy. Transplantation immunology. – Auto-inflammatory diseases and autoimmune diseases. Allergies. The primary and secondary immunodeficiencies.
Prerequisites	For the understanding of the course are necessary notions of Biochemistry and Molecular Cell Biology, Genetics, Anatomy, Histology.
Teaching methods	Frontal lessons
Other information
Learning verification modality	Oral exam
Extended program	The immune system: purpose, organization and components; Innate and adaptive immunity; systems immunology. Inflammation. Regulation of inflammation: The role of the microbiota. Antigen processing and presentation; activation of lymphocytes T and B. Central and peripheral immune tolerance. Immunological memory. The antimicrobial response. Immunology and cancer immunotherapy. Transplantation immunology. Auto-inflammatory diseases and autoimmune diseases. Allergies. The primary and secondary immunodeficiencies.