Unit INTERNAL MEDICINE 2

INTERNAL MEDICINE - MOD. 1

Code	GP004592
Location	TERNI
CFU	2
Teacher	Stefano Coaccioli
Teachers	Stefano Coaccioli
Hours	24 ore - Stefano Coaccioli
Learning activities	Caratterizzante
Area	Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica
Academic discipline	MED/09
Type of study-unit	Obbligatorio (Required)

INTERNAL MEDICINE - MOD. 2

Code	GP004593
Location	TERNI
CFU	2
Teacher	Gaetano Vaudo
Teachers	Gaetano Vaudo
Hours	24 ore - Gaetano Vaudo
Learning activities	Caratterizzante
Area	Clinica generale medica e chirurgica
Academic discipline	MED/09
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Principles of symptoms and signs of diseases.
Reference texts	1) Harrison. Principi di medicina interna. 19a edizione. Casa Editrice Ambrosiana. 2) Goldman-Cecil. Medicina Interna. 25a edizione. Casa Editrice EDRA.
Educational objectives	Prepare for the approach to internal diseases with the ability to differential diagnose, clinical and diagnostic-therapeutic aspects.
Prerequisites	Knowledge of the pathophysiological basis of the main internal medicine diseases.
Teaching methods	Face to face lessons
Learning verification modality	Oral examination
Extended program	The practice and the global aspects of medicine. Decision-making in clinical medicine. Screening and disease prevention. Principles of clinical pharmacology. Medical evaluation of the surgical patient. Palliative care and assistance to terminally ill patients. Clinical problems of aging. Safety and quality of health care. ALTERATIONS OF THE BODY TEMPERATURE Temperature. Fever and rashes. Fever of unknown origin. ACHE Pain: pathophysiology and treatment. Chest pain. Abdominal pain. Headache. Pain in the back and neck. DYSFUNCTIONS OF THE NERVOUS SYSTEM Syncope. Dizziness and vertigo. Neurological causes of weakness and paralysis. Disorders of walking and balance. Confusion and delirium. Dementia. Aphasia, amnesia and other focal brain disorders. Progressive primary aphasia, loss of memory and other focal brain disorders. ALTERATIONS RESPIRATORY AND CIRCULATORY FUNCTIONS Dyspnea. Cough and hemoptysis. Hypoxia and cyanosis. Edema. ALTERATIONS GASTROINTESTINAL FUNCTIONS Dysphagia. Nausea, vomiting and other digestive disorders. Diarrhea and constipation. Unintentional weight loss. Gastrointestinal bleeding. Jaundice. Abdominal distension and ascites. ALTERATIONS OF THE RENAL FUNCTION AND THE URINARY WAYS Disuria, bladder pain and interstitial cystitis / painful bladder syndrome. Hyperazotemia and urinary changes. Alterations of liquids and electrolytes. Hydroelectrolyte imbalances and acid-base disturbances. Hypercalcemia and hypocalcemia. Acidosis and alkalosis. DERMATOLOGICAL ALTERATIONS Eczema, psoriasis, skin infections, acne and other common skin conditions. Cutaneous manifestations of systemic diseases. Immunomediate skin diseases. Skin reactions from drugs. Photosensitization and other reactions to light. HEMATOLOGICAL ALTERATIONS Anemia and polycythemia. Hemorrhage and thrombosis. Lymphadenopathy and splenomegaly. Alterations of granulocytes and monocytes. GENES, ENVIRONMENT AND DISEASES Principles of human genetics. Chromosomal disorders. Applications of genetics in medicine. Mitochondrial DNA, inheritable traits and diseases. Human microbiome. REGENERATIVE MEDICINE Stem cell biology. Hematopoietic stem cells. Applications of stem cell biology in clinical medicine. Gene therapy in clinical medicine. Tissue engineering. AGING Demography of aging in the world. Biology of aging. WEIGHT NUTRITION AND LOSS Nutritional needs and diet evaluation. Deficiency and excess of vitamins and trace minerals. Malnutrition and evaluation of nutritional status. Enteral and parenteral nutritional therapy.

INTERNAL MEDICINE - MOD. 3

Code	GP004594
Location	TERNI
CFU	2
Teacher	Stefano Coaccioli
Teachers	Stefano Coaccioli
Hours	24 ore - Stefano Coaccioli
Learning activities	Caratterizzante
Area	Clinica generale medica e chirurgica
Academic discipline	MED/09
Type of study-unit	Obbligatorio (Required)

INTERNAL MEDICINE - MOD. 4

Code	GP004798
Location	TERNI
CFU	2
Teacher	Gaetano Vaudo
Teachers	Gaetano Vaudo
Hours	24 ore - Gaetano Vaudo
Learning activities	Caratterizzante
Area	Medicina delle attività motorie e del benessere
Academic discipline	MED/09
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Neoplastic and infectious diseases.
Reference texts	1) Harrison. Principi di medicina interna. 19a edizione. Casa Editrice Ambrosiana. 2) Goldman-Cecil. Medicina Interna. 25a edizione. Casa Editrice EDRA.
Educational objectives	Clinical, diagnostic and therapeutic aspects of neoplastic and infectious diseases.
Prerequisites	Knowledge of the pathophysiological basis of the main internal medicine diseases.
Teaching methods	Face to face lessons.
Learning verification modality	Oral examination.
Extended program	NEOPLASTIC DISEASES Approach to the patient with cancer. Prevention and early diagnosis of tumors. Cancer genetics. Tumor cell biology. Principles of anticancer therapy. Infections in patients with neoplasms. Skin tumors. Cancer of the head and neck. Lung neoplasms. Carcinoma of the breast. Upper gastrointestinal cancer. Lower gastrointestinal cancer. Tumors of the liver and biliary tract. Pancreatic cancer. Endocrine tumors of the gastrointestinal tract and pancreas. Carcinomas of the bladder and kidney. Benign and malignant diseases of the prostate. Testis cancer. Malignant gynecological malignancies. Primitive and metastatic tumors of the nervous system. Soft tissue and bone sarcomas and bone metastases. Carcinoma with unknown primary site. Endocrine / haematological paraneoplastic syndromes. Paraneoplastic neurological syndromes and autoimmune encephalitis. Thymoma. Neoplasms during pregnancy. Late consequences of cancer and its treatment. ALTERATIONS OF THE HEMATOPIESIS Iron deficiency anemia and other hypoproliferative anemia. Haemoglobinopathies. Megaloblastic anemias. Hemolytic anemias and secondary anemias of acute haemorrhage. Medullary insufficiency syndromes: aplastic anemia and myelodysplasia. Polycythemia vera and other myeloproliferative neoplasms. Acute myeloid leukemia. Chronic myelogenous leukemia. Neoplasms of the lymphatic cells. Less common hematological malignancies. Plasmacellular discrasias. Amyloidosis. Biology and transfusion therapy. Hematopoietic cell transplantation. ALTERATIONS OF THE EMOSTASIS Alterations of the platelets and the vessel wall. Coagulation defects. Arterial and venous thrombosis. Anti-platelet drugs, anticoagulants and fibrinolytic drugs. INFECTIOUS DISEASES Approach to the patient with infectious pathology. Molecular mechanisms of microbial pathogenesis. Genomics and infectious diseases. Approach to the patient with acute febrile infection. Immunization principles and use of vaccines. Health recommendations for international travelers. Laboratory diagnosis of infectious diseases. Climate change and infectious diseases. Pneumonia. Lung abscess. Infectious endocarditis. Infections of the skin, muscles and soft tissues. Infectious arthritis. Osteomyelitis. Infections and intra-abdominal abscesses. Acute diarrheal infectious diseases and toxins. Clostridium difficile infection, including pseudomembranous colitis. Urinary tract infections, pyelonephritis and prostatitis. Sexually transmitted infections: general overview and clinical approach. Meningitis, encephalitis, brain abscess and empyema. Chronic and recurrent meningitis. Burns infections. Bite infections. Infections acquired in a healthcare environment. Infections in the patient undergoing transplantation. Treatment and prophylaxis of bacterial infections. Pneumococcal infections. Staphylococcal infections. Streptococcal infections. Enterococcal infections. Diphtheria and other infections caused by Corynebacteria. Listeria monocytogenes infections. Tetanus. Botulism. Gaseous gangrene and other clostridia infections. Meningococcal infections. Gonococcal infections. Haemophilus and Moraxella infections. Bacterial infections of the HACEK group and other Gram-negative bacteria. Legionella infections. Pertussis and other infections with Bordetella. Diseases caused by Gram-negative enteric bacilli. Acinetobacter infections. Helicobacter pylori infections. Pseudomonas infections and related microorganisms. Salmonellosis. Shigellosis. Campylobacter infections and related microorganisms. Cholera and other diseases caused by vibrios. Brucellosis. Tularemia. Plague and other Yersinia infections. Bartonella infections, including cat scratch disease. Tuberculosis. Leprosy. Non-tuberculous mycobacterial infections. Antimycobacterial agents. Syphilis. Endemic treponematosis. Leptospirosis. Recurrent fever. Lyme borreliosis. Diseases from rickettsias. Mycoplasma infections. Chlamydia infections.