Unit SYSTEMIC PATHOLOGY V

BLOOD DISEASES - MOD. 1

Code	GP002620
Location	TERNI
CFU	2
Teacher	Franca Falzetti
Teachers	Franca Falzetti
Hours	18 ore - Franca Falzetti
Learning activities	Caratterizzante
Area	Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)

BLOOD DISEASES - MOD. 2

Code	GP002621
Location	TERNI
CFU	1
Teacher	Franca Falzetti
Teachers	Franca Falzetti
Hours	9 ore - Franca Falzetti
Learning activities	Caratterizzante
Area	Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)

DISEASES OF THE IMMUNE SYSTEM

Code	GP002618
Location	TERNI
CFU	2
Teacher	Loredana Ruggeri
Teachers	Loredana Ruggeri
Hours	24 ore - Loredana Ruggeri
Learning activities	Caratterizzante
Area	Medicina delle attività motorie e del benessere
Academic discipline	MED/09
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Immunodeficenze, autoimmunità organispecifiche e sindromi da ipersensibilità
Reference texts	HARRISON "TRATTATO DI MEDICINA INTERNA"
Educational objectives	capacità di diagnosi di immunoincompetenza e autoimmunità
Prerequisites	Conoscenza della fisiologia del sistema immune
Teaching methods	Lezioni frontali teoriche ed esercitazioni pratiche
Learning verification modality	esami orali
Extended program	Le immunodeficienze: meccanismi patogenetici del rischio infettivo e diagnostica delle immunodeficienze. Quadri clinic. Immunodeficienze primarie: Malattie da deficit anticorporali: X-linked Agammaglobulinemia, Immunodeficienza comune Variabile, Deficit IgA. Immunodeficienze Severe Combinate: Interleukin receptor gamma-chain deficiency, Recombinase activating gene deficiency. Immunodeficienze da deficit di funzione granulocitaria: Malattia granulomatosa cronica Le immunideficienze secondarie: AIDS: immunopatogenesi, storia naturale della malattia, quadri clinici principali. Immunodeficienze secondarie (non AIDS): Dopo splenectomia In corso di malattie linfoproliferative In corso di terapia immunosoppressiva e citostatica Dopo trapianto di cellule ematopoietiche,ecc. Malattie da ipersensibilità immediata: Orticaria e angiodema, Allergie alimentari Rinite allergica, Asma. Le malattie autoimmuni: Patogenesi immunologica delle principalei malattie autoimmuni organo specifiche: Tiroidite di Hashimoto, diabete Mellito, sclerosi multipla, Anemia Aplastica, Anemia e pistrinopenie autoimmuni,ecc. Le malattie da immunocomplessi (vasculiti): immunopatogenesi e quadri clinici: porpora di Schonlein-Henoch, epatiti. La malettia da siero e vasculiti da farmaci. Criglobulinemie

MOLECULAR MEDICINE

Code	GP002622
Location	TERNI
CFU	1
Teacher	Cristina Mecucci
Teachers	Cristina Mecucci
Hours	12 ore - Cristina Mecucci
Learning activities	Caratterizzante
Area	Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Approcci tecnologici per lo studio del genoma. - Cellula staminale leucemica e tumorale, processo multistep dell'oncogenesi, meccanismi di alterazione di oncogeni, oncosoppressori, geni del riparo e geni check-point. - Modelli di patogenesi di insufficienze midollari congenite e acquisite. - Modelli di patogenesi di Leucemie Acute. - Tirosinchinasi. - Modelli di patogenesi di disordini linfoproliferativi. - Modelli di patogenesi di Mieloma. - Modelli di patogenesi di tumori solidi (polmone; mammella; colon).
Reference texts	il materiale sarà fornito dal docente.
Teaching methods	lezione frontale
Learning verification modality	esame scritto Per informazioni sui servizi di supporto agli studenti con disabilità e/o DSA visita la pagina http://www.unipg.it/disabilita-e-dsa
Extended program	Approcci tecnologici per lo studio del genoma. - Cellula staminale leucemica e tumorale, processo multistep dell'oncogenesi, meccanismi di alterazione di oncogeni, oncosoppressori, geni del riparo e geni check-point. - Modelli di patogenesi di insufficienze midollari congenite e acquisite. - Modelli di patogenesi di Leucemie Acute. - Tirosinchinasi. - Modelli di patogenesi di disordini linfoproliferativi. - Modelli di patogenesi di Mieloma. - Modelli di patogenesi di tumori solidi (polmone; mammella; colon).

REUMATHOLOGY

Code	GP002619
Location	TERNI
CFU	2
Teacher	Elena Bartoloni Bocci
Teachers	Elena Bartoloni Bocci
Hours	24 ore - Elena Bartoloni Bocci
Learning activities	Caratterizzante
Area	Clinica delle specialità medico-chirurgiche
Academic discipline	MED/16
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Definition, classification and epidemiology of rheumatic diseases. Etiopathogenesis and clinical manifestations of rheumatic diseases. Chronic inflammatory rheumatic diseases. Connective tissue diseases. Vasculitides. Gout and pseudo-gout. Extra-articular localized and generalized rheumatic diseases.
Reference texts	REUMATOLOGIA per studenti e medici di Medicina Generale- II edizione; a cura di UNIREUMA. IDELSON GNOCCHI Ed. 2014 Fauci A.S., Braunwald E. HARRISON- Principi di Medicina Interna - Edizione XVII - McGraw-Hill Eds 2009.
Educational objectives	At the end of the Course students are expected to recognize and define the peculiar features of most common chronic articular conditions, both inflammatory and degenerative, extra-articular rheumatic diseases, systemic autoimmune diseases and systemic vasculitis, from an etiologic, pathogenic and, most importantly, clinical point of view. In addition, the students are asked to prove the ability to recognize and interpret the laboratory tests specific for the aforementioned conditions and the most common instrumental procedures employed in rheumatology clinics. The students’ diagnostic approach based on signs and symptoms will also be evaluated.
Prerequisites	Knowledge of anatomy and symptoms of the most common diseases of internal medicine. Ability to read and interpret routine laboratory exams.
Teaching methods	Face-to face lessons on all the subjects of the course Practical training in Rheumatology clinic. Students will be divided in groups (maximum 3 students per group) and will be involved in the clincal evaluation of patients with rheumatologic diseases
Other information	Compulsory frequency (at least 75% of lessons) Teaching methods: power-point, radiographic images, clinical picture
Learning verification modality	The exam includes a multiple choice written test (30 questions with up to 5 possible answers of which only 1 correct). Questions will cover all rheumatology topics and can be afforded with a basic knowledge of such topics. The oral exam is open to students who passed the first written test and includes wider questions aimed at evaluating theoretical and practical skills as well as deductive processes and communication. The average examination time is 20-25 minutes.
Extended program	1. Definition, classification and epidemiology of rheumatic diseases 2. Osteoarticular system anatomy 3. Etiopathogenesis of rheumatic diseases 4. Signs and simpthoms of rheumatic diseases 5. Laboratory exams and imaging of rheumatic diseases. Synovial fluid analysis 6. Chronic inflammatory rheumatic diseases: Rheumatoid arthritis Spondyloarthopaties (ankylosing spondylitis, psoriasic arthritis, reactive arthritis, enteropathic arthritis) 7. Connective tissue diseases Systemic lupus erythematosus Antiphospholipid antibodies syndrome Systemic sclerosis Polimyositis/Dermatomyositis Sjogren's syndrome Mixed connective tissue disease Undifferentiated connective tissue disease 8. Systemic vasculitides Takayasu arteritis/ Horton arteritis Panarteritis nodosa ANCA-associated vasculitides 9. Secondary systemic vasculitides 10. Bechet disease 11. Rheumatic polymyalgia 12. Septic arthritis. Post-infection arthritis 13. Gout and pseudo-gout 14. Osteoarthritis 15. Extra-articular localized and generalized rheumatic diseases 16. Neurologic and neurovascular syndrome (algodystrophy, Raynaud's phenomenon) 17. Sarcoidosis

PROFESSIONALISING TRAINING IN BLOOD DISEASES

Code	GP002625
Location	TERNI
CFU	1
Teacher	Anna Marina Liberati
Teachers	Anna Marina Liberati
Hours	20 ore - Anna Marina Liberati
Learning activities	Altro
Area	Tirocini formativi e di orientamento
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)

PROFESSIONALISING TRAINING IN DISEASES OF THE IMMUNE SYSTEM

Code	GP002623
Location	TERNI
CFU	1
Teacher	Andrea Velardi
Teachers	Andrea Velardi
Hours	20 ore - Andrea Velardi
Learning activities	Altro
Area	Tirocini formativi e di orientamento
Academic discipline	MED/09
Type of study-unit	Obbligatorio (Required)

PROFESSIONALISING TRAINING IN MOLECULAR MEDICINE

Code	GP002626
Location	TERNI
CFU	1
Teacher	Cristina Mecucci
Teachers	Cristina Mecucci
Hours	20 ore - Cristina Mecucci
Learning activities	Altro
Area	Tirocini formativi e di orientamento
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)

PROFESSIONALISING TRAINING IN REUMATHOLOGY

Code	GP002624
Location	TERNI
CFU	1
Teacher	Elena Bartoloni Bocci
Teachers	Elena Bartoloni Bocci
Hours	20 ore - Elena Bartoloni Bocci
Learning activities	Altro
Area	Tirocini formativi e di orientamento
Academic discipline	MED/16
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Clinical and practical activity in clinic with Rheumatologists: clinical history, physical examination, diagnosis and therapeutic prescription of all chronic inflammatory and autoimmune diseases and degenerative articular diseases. Evaluation of patients treated with infusion of biologic agents. Opportunity to assist at instrumental activity by ultrasound evaluation of muscle-skeletal diseases and ultrasound-driven arthrocentesis and infiltration of joints, tendons and bursas. Diagnosis of microcirculation disorders by capillaroscopic examination. Evaluation of patients with foot and posture disorders.
Reference texts	REUMATOLOGIA per studenti e medici di Medicina Generale- II edizione; a cura di UNIREUMA. IDELSON GNOCCHI Ed. 2014. ¿ Fauci A.S., Braunwald E. HARRISON- Principi di Medicina Interna - Edizione XVII - McGraw-Hill Eds 2009.
Educational objectives	Differential diagnosis of chronic inflammatory joint diseases and systemic autoimmune diseases.
Prerequisites	Knowledge of anatomy and semiotics
Teaching methods	Partecipation to the above described activities with a specialist physician
Other information	Training can be carried out over the whole academic year. Days to be defined with professor by email.
Learning verification modality	Results based on check of the acquired ability, behaviour and interaction degree of the student.
Extended program	See above.