Medical, veterinary and forensic biotechnological sciences
Study-unit Code
In all curricula
Martina Mandarano
  • Martina Mandarano
  • Stefania Pieroni
  • 28 ore - Martina Mandarano
  • 24 ore - Stefania Pieroni
Course Regulation
Coorte 2023
Learning activities
Medicina di laboratorio e diagnostica
Academic discipline
Type of study-unit
Obbligatorio (Required)
Type of learning activities
Attività formativa monodisciplinare
Language of instruction
Histopathological and molecular study of the causes of human diseases, with particular regard to the etiopathogenetic mechanisms, to the histological presentations (macro- and microscopic); main applications of the histopathological and molecular biology techniques, particularly as regards the diagnostic-therapeutic implications in the oncological field.
Reference texts
- Kumar M, Abbas AK, Aster JC: Robbins e Cotran - Le Basi Patologiche delle Malattie - 2 Volumi X Edizione. 2021 Edizioni EDRA or
- English edition: Kumar M, Abbas AK, Aster JC: Robbins and Cotran - Pathologic Basis of Disease 10th Edition. 2020 Elsevier
- G Pelosi, A Sapino, E Maiorano: Manuale di Anatomia Patologica Funzionale 2022 Edizioni Minerva Medica
- Simon Herrington C: Anatomia Patologica di Muir Quindicesima edizione 2017 EMSI
- A Fassina, R Cappellesso: Anatomia patologica e citopatologia per TLB 2019 Cleup (www.cleup.it)
- L.Ruco, A.Scarpa: Anatomia Patologica - Le Basi. 2007 UTET
Educational objectives
The Histological and Anatomical Basis of Human Diseases studies the causes (etiology) and pathological phenomena (pathogenesis), at both the histopathological and molecular level, as well as the main techniquest for the biopathological characterization of the most common human neoplasms, for prognostic and therapeutic purposes. The course allows students to acquire knowledge about the basic mechanisms underlying the most frequent human diseases, such as oncological or cardiovascular diseases.
The skills acquired in the study of this discipline will allow the student to achieve a broad overview of the correlation between the environment, the main extrinsic and intrinsic risk factors, the etiopathogenetic and molecular mechanisms and the development of pathologies; moreover it will allow to obtain the tools to have a clear picture of the causes of the pathologies and their specific mechanism of onset and development, in order to propose appropriate behaviors and lifestyles and, furthermore, identify the appropriate therapeutic targets/discover new therapeutic targets for treatments, also as personalized as possible.
The acquisition of knowledge relevant to the course of HISTOLOGICAL AND ANATOMICAL BASIS OF HUMAN DISEASES requires the achievement of notions relevant to Biology and Genetics, Histology, Biochemistry, Physiology and General and Molecular Pathology. The skills obtained in the aforementioned disciplines are essential for the student to fully understand the concepts of etio-pathogenesis of histology and pathological anatomy.
The student thus prepared at the didactic level will derive a considerable profit from the course.
Teaching methods
Taught lessons.

Practical activity at the laboratory of General Pathology.

There are courses, materials and/or assessment methods consistent with the needs of students with disabilities and / or SLDs.
Other information
Office hours: Thursday 15-17 (by appointment), also through video call on the Teams platform.
e-mail address: martina.mandarano@unipg.it
Phone number: +39 075 5782510
Learning verification modality
Oral exam

The exam relating to this module includes an oral test of about 15 minutes which will focus on 2 questions relating to theoretical topics indicated in the program (Systematic Pathology e Special part) + 1 question about the special part of laboratory practice (Prof. Stefania Pieroni's program)
The purpose of the oral exam is to verify the level of knowledge reached by the student on the theoretical contents indicated in the program, in order to evaluate the student’s ability to present them, with language properties and terminological appropriateness, as well as student’s problem-solving skills, related to the use of molecular biology techniques in the Anatomic Pathology field.

There are courses, materials and / or assessment methods consistent with the needs of students with disabilities and / or SLDs.

For information on support services for students with disabilities and / or SLDs, visit the page http://www.unipg.it/disabilita-e-dsa
Extended program
Role of Anatomic Pathology in modern medicine and biotechnology
Systematic Pathology:
Aneurysms and dissections
Diseases associated with vascular prostheses
Heart failure
Ischemic heart disease
Valvular heart disease.
Pathologies associated with prosthetic valves
Congenital heart disease
Embolism and pulmonary infarction
Chronic obstructive and restrictive lung disease
Lung tumors
Colorectal cancer
Alcoholic liver disease. Cirrhosis
Breast: inflammatory disorders. Benign and preneoplastic epithelial lesions. Breast carcinoma. Benign breast tumors
Role of Anatomic Pathology in the biopathological characterization of the most common human neoplasms, for prognostic and therapeutic purposes
Special Part:
The Laboratory of Anatomic Pathology: fixation, processing, embedding, sectioning, staining
Histochemical and immunohistochemical techniques. Immunofluorescence
In situ hybridization techniques: FISH; CISH; SISH
Molecular Biology Techniques in Anatomic Pathology
Tissue microarray

Laboratory Practice Prof. Stefania Pieroni
Condividi su