Unit MOLECULAR AND CELLULARBASESOF LIFE
- Course
- Nursing
- Study-unit Code
- GP005080
- Location
- FOLIGNO
- Curriculum
- In all curricula
- Teacher
- Cinzia Antognelli
- CFU
- 5
- Course Regulation
- Coorte 2023
- Offered
- 2023/24
- Type of study-unit
- Obbligatorio (Required)
- Type of learning activities
- Attività formativa integrata
BIOCHEMISTRY
Code | GP005095 |
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Location | FOLIGNO |
CFU | 2 |
Teacher | Tommaso Beccari |
Teachers |
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Hours |
|
Learning activities | Base |
Area | Scienze biomediche |
Academic discipline | BIO/10 |
Type of study-unit | Obbligatorio (Required) |
Language of instruction | Italian |
Contents | Cell biochemistry |
Reference texts | Biochimica e Biologia per le professioni sanitarie Edizioni Mc Graw Education |
Educational objectives | To understand the principle of biochemistry |
Prerequisites | Principles of inorganic and organic chemistry - Biology of the cell |
Teaching methods | Frontal lessons |
Other information | None |
Learning verification modality | Written exam |
Extended program | Water and biological buffers - amino acids, peptides and proteins - tridimensinal strucure of proteins- protein functions - enzyme and enzyme catalysis - carbohydrates and glycobiology - monosaccharides- disaccharides and polysaccharides - nucleic acid - lipids- storage lipis - structural lipids- biological membranes - membrane transport - biosignaling - bioenergetics and metabolism- glycolisis and gluconeogensis - Krebs cycle - catabolism of fatty acids - aminoacids oxidation and urea cycle - oxidative phosphorilation - biosynthesis of carbohydrates - biosynthesis of aminoacids - hormonal regulation - protein metabolism - |
APPLIED BIOLOGY AND GENETICS
Code | GP005097 |
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Location | FOLIGNO |
CFU | 2 |
Teacher | Cinzia Antognelli |
Teachers |
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Hours |
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Learning activities | Base |
Area | Scienze biomediche |
Academic discipline | BIO/13 |
Type of study-unit | Obbligatorio (Required) |
Language of instruction | Italian |
Contents | Characteristics of living organisms. Biological macromolecules. Prokaryotic and eukaryotic cells. Viruses (overview). Flow of genetic information within a biological system and its regulation. Cell cycle and its control. Mutations: types and causes. Reproduction of multicellular living organisms: meiosis and gametogenesis. Basic concepts of formal genetics. Basic concepts of medical genetics. Blood types: immunological and genetic approach. |
Reference texts | R. Roberti, G. Alunni Bistocchi, C. Antognelli, VN Talesa - Biochimica e Biologia per le professioni sanitarie – McGrawHill P. Bonaldo, S. Suga, R. Pierantoni, P. Riva, M.G, Romanelli- Biologia e Genetica – EdiSES |
Educational objectives | The aim of the course is the integrated study of the cell and living organisms, with emphasis on the mechanisms involved in: organelles biogenesis and cellular structures, cell-cell interactions, cell-extracellular matrix interactions, DNA duplication, transmission of the genetic information, gene expression, cell proliferation, general and human genetics. The ability to learn, relate and integrate one concept to another will be considered fundamental issues in order to facilitate the understanding of the disciplines provided in the subsequent years of the Degree Course. |
Prerequisites | Basic elements of chemistry. |
Teaching methods | Face-to-face. |
Other information | Site of the teacher: Department of Medicine and Surgery - Edificio B, 4° floor- P.le L. Severi 1 - Sant'Andrea delle Fratte - Perugia. Student reception: the professor is always available to receive students upon request via email (cinzia.antognelli@unipg.it). |
Learning verification modality | Integrated written examination (with Biochemistry and Physiscs that belong to the same teaching (Molecular and Cellular Bases of Life). 24 questions of Applied Biology, 24 questions of Biochemistry and 12 of Physics are administered (based on the credits of each module, 2,2, and 1 respectively). The written test therefore consists of 60 single-answer questions to be completed in 60 minutes. One point is awarded for correct answers, 0 points for those that are wrong or not given. |
Extended program | The characteristics of living organisms. Biological macromolecules: proteins, lipids and glucides (general characteristics). Models of cellular organization: prokaryotes and eukaryotes. Viruses: general characteristics. Animal eukaryotic cell. Plasma membrane: structure and functions. The main mechanisms of membrane transport and cellular communication; cytoplasm; ribosomes; rough and smooth endoplasmic reticulum; Golgi apparatus; lysosomes; peroxisomes; mitochondria and the energy problem; cytoskeleton (general characteristics), nucleus and nucleolus. DNA and RNA: structure and function. Organization of chromatin, chromosomes. The eukaryotic gene. Gene expression: transcription, maturation of primary transcripts, genetic code, translation. Regulation of gene expression: general characteristics. Cell cycle: interphase, DNA replication, mitosis. Cell cycle control: check-point and CdK-cyclines. Proto-oncogenes, oncogenes and tumor suppressor. Gene mutations (point mutations, missense, nonsense, neutral mutations), genomic mutations (aneuploidy and polyploidy mutations) and chromosomal mutations (deletion, duplication, inversion, translocation). Human normal and pathological karyotype. Heterochromatinization of the X chromosome. Reproduction of multicellular organisms; meiosis and its biological meaning, gametogenesis (spermatogenesis and oogenesis). Basic concepts of formal genetics: allele, haploid and diploid organisms, genotype, phenotype, homozygous and heterozygous organisms, dominance, recessiveness, Mendel's laws and extensions to Mendelian analysis (incomplete dominance, codominance, multiple alleles). Basic concepts of medical genetics: family trees, dominant and recessive autosomal inheritance, sex-linked inheritance (X-linked and Y-linked). Multifactorial and polygenic inheritance. Mitochondrial inheritance. Blood types. |
Obiettivi Agenda 2030 per lo sviluppo sostenibile | Health and wellness. |
PHYSIC
Code | GP005096 |
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Location | FOLIGNO |
CFU | 1 |
Teacher | Massimiliano Paolucci |
Teachers |
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Hours |
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Learning activities | Base |
Area | Scienze propedeutiche |
Academic discipline | FIS/07 |
Type of study-unit | Obbligatorio (Required) |