Unit SYSTEMIC PATHOLOGY V

BLOOD DISEASES - MOD. 1

Code	GP004821
CFU	2
Teacher	Arcangelo Liso
Teachers	Arcangelo Liso
Hours	25 ore - Arcangelo Liso
Learning activities	Caratterizzante
Area	Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)

BLOOD DISEASES - MOD. 2

Code	GP004822
CFU	1
Teacher	Arcangelo Liso
Teachers	Arcangelo Liso
Hours	12.5 ore - Arcangelo Liso
Learning activities	Caratterizzante
Area	Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)

DISEASES OF THE IMMUNE SYSTEM

Code	GP005900
CFU	2
Teacher	Andrea Pierini
Teachers	Antonio Pierini (Codocenza)
Hours	25 ore (Codocenza) - Antonio Pierini
Learning activities	Caratterizzante
Area	Medicina delle attività motorie e del benessere
Academic discipline	MED/09
Type of study-unit	Obbligatorio (Required)

MOLECULAR MEDICINE

Code	GP004823
CFU	1
Teacher	Roberta La Starza
Teachers	Roberta La Starza
Hours	12.5 ore - Roberta La Starza
Learning activities	Caratterizzante
Area	Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Technological approaches for genome study: cytogenetics, molecular cytogenetics, microarrays, NGS, WET assay. Leukemic and cancer stem cells, multistep process of oncogenesis; mechanisms of deregulation of oncogenes, oncosuppressors, repair genes and check-point genes. Basic principles of epigenetic regulation in DNA transcription and gene expression Hematopietic clonality, clonal hematopoiesis and human diseases, and pathogenesis of leukemias. Pathogenesis models of congenital and acquired bone marrow failures. Patterns of pathogenesis of acute leukemias. Function of tyrosine kinases. Models of pathogenesis of lymphoproliferative disorders. Models of pathogenesis of myeloma. Patterns of pathogenesis of solid tumors (central nervous system).
Reference texts	The material will be provided by professor.
Educational objectives	Learning study approaches for genetic and epigenetic characterization of blood diseases. Fundamental basis for understanding the processes of oncogenesis of major hematologic cancers.
Prerequisites	Basic concepts of molecular biology.
Teaching methods	Frontal lessons; Seminars.
Other information	None.
Learning verification modality	Multiple choice quiz or oral exam.
Extended program	Technological approaches for genome study: conventional cytogenetics, fluorescence in situ hybridization (interphase, metaphase, on tissue), multi-FISH, arrays on DNA and RNA, NGS targets. Characteristics of leukemic and cancer stem cell Study of the multistep process of oncogenesis, mechanisms of alteration of oncogenes, oncosuppressors, repair genes and check-point genes. Intratumoral heterogeneity, clonality, and subclonality of genomic alterations. Oncogenes and oncosuppressors: role and type of deregulation. Principles of epigenetic regulation, both at the transcriptional and post-transcriptional levels. Patterns of pathogenesis of congenital and acquired bone marrow failure. Patterns of pathogenesis of Acute and chronic Leukemias. Function and involvement of tyrosine kinases in human neoplasms. Pathogenesis models of Multiple Myeloma and Lymphomas. Patterns of pathogenesis of solid tumors (central nervous system).
Obiettivi Agenda 2030 per lo sviluppo sostenibile	3 - Health

REUMATHOLOGY

Code	GP005901
CFU	2
Teacher	Carlo Perricone
Teachers	Carlo Perricone
Hours	25 ore - Carlo Perricone
Learning activities	Caratterizzante
Area	Clinica delle specialità medico-chirurgiche
Academic discipline	MED/16
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Classification, epidemiology and pathogenesis of rheumatic disease. Clinical features of most common acute and chronic osteoarticular disease, inflammatory and not, of extra-articular rheumatism, of systemic autoimmune disease and of systemic vasculitides.
Reference texts	Reumatologia. Per studenti e medici di medicina generale a cura di UNIREUMA. IDELSON GNOCCHI IV Ed. 2022. HARRISON et al. Principles of Internal Medicine XX Ed. McGraw Hill Ed. Malattie Autoimmuni Sistemiche di Roberto Perricone, SEU
Educational objectives	At the end of the study course students are expected to recognize and define the peculiar features of most common chronic articular conditions, both inflammatory and degenerative, extra-articular rheumatic diseases, systemic autoimmune diseases, and systemic vasculitis, from an etiologic, pathogenic and, most importantly, clinical point of view. In addition, the students are asked to prove the ability to recognize and interpret the specific laboratory tests for the aforementioned conditions and the most common instrumental procedures employed in rheumatology clinics. The students’ diagnostic approach based on signs and symptoms will also be evaluated.
Prerequisites	In order to start Rheumatology lessons, the student should have good knowledge of anatomy and physiopathology and good skill in general physical examination of the patient.
Teaching methods	The Course includes 25 hours with 14 theoretical hours and 11 hours of practical skills and practical training or seminars.
Other information	Overarching objectives are recognition, the main therapeutic guidelines and indications for the professional contribution of the specialist in the most frequent rheumatological diseases.
Learning verification modality	An oral examination lasting usually 20-25 minutes will include the recognition of clinical, radiological and histopathological aspects of rheumatologic iconography and questions aimed at evaluating theoretical and practical skills as well as communication and deductive processes. Evaluation criteria: Unsuccessful: significant lack and/or inaccuracies in knowledge and understanding of the topics; limited capacity for analysis and synthesis, frequent generalisations. 18-20: sufficient knowledge and understanding of topics with possible imperfections; sufficient ability to synthesize and state independent judgment. 21-23: Knowledge and understanding of routine topics; Correct analysis and synthesis skills with coherent logical argumentation. 24-26: Fair knowledge and understanding of the topics; good analytical and synthetical skills with rigorously expressed arguments. 27-29: Thorough knowledge and understanding of topics; remarkable skills of analysis and synthesis. Good autonomy of judgment. 30-30L: Excellent level of knowledge and understanding of the topics. Remarkable capacity for analysis and synthesis and independent judgement. Arguments expressed in an original way.
Extended program	1. Definition, classification and epidemiology of rheumatic diseases 2. The musculoskeletal system: anatomic and functional elements 3. Etiopathogenic mechanisms of rheumatic diseases 4. Signs and symptoms of rheumatic diseases 5. Laboratory and imaging diagnosis and synovial fluid analysis 6. Inflammatory joint diseases a) Rheumatoid arthritis and other related joint diseases b) Spondylarthritis i. Ankylosing Spondylitis ii. Reactive arthritis iii. Psoriatic arthritis iv. Enteropathic arthritis c. Polymyalgia rheumatica 7. Connective tissue diseases a) Systemic lupus erythematosus b) Antiphospholipid syndrome c) Systemic sclerosis d) Polymyositis/Dermatomyositis/ Inflammatory myopathies/Anti-synthetase syndrome e) Sjögren's syndrome f) Overlap syndromes, included mixed connective tissue disease g) Undifferentiated connective tissue diseases (UCTD) 8. Primary systemic vasculitides a) Large size-arteries: Takayasu arteritis, Horton arteritis b) Medium-size arteries: polyarteritis nodosa c) Medium and small-size vessels ANCA-associated (micropolyangiitis, granulomatosis with polyangiitis - Wegener's granulomatosis; eosinophilic granulomatosis with polyangiitis - Churg-Strauss syndrome) 9. Small-size vessels a) Behçet's disease b) cryoglobulinemia c) IgA vasculitis - Schönlein-Henoch purpura 10. Septic and post-infective arthritis (rheumatic fever) 11. Microcrystal arthropaties (Gout, Calcium pyrophosphate dihydrate and hydroxyapatite deposition disorders) 12. Osteoarthritis 13. Localized and generalized extra-articular rheumatic diseases and fibromyalgia 14. Neurovascular and neurologic syndrome a) Raynaud 's phenomenon b) Carpal tunnel syndrome 15. Autoinflammatory disorders a. Monogenic autoinflammatory diseases b. Adult onset Still’s disease 16. Miscellaneous disorders associated with rheumatologic manifestations a. Sarcoidosis b. IgG4-related disease

PROFESSIONALISING TRAINING IN BLOOD DISEASES

Code	GP004824
CFU	1
Teacher	Arcangelo Liso
Teachers	Arcangelo Liso
Hours	25 ore - Arcangelo Liso
Learning activities	Altro
Area	Tirocini formativi e di orientamento
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)

PROFESSIONALISING TRAINING IN DISEASES OF THE IMMUNE SYSTEM

Code	GP005902
CFU	1
Teacher	Andrea Pierini
Teachers	Antonio Pierini (Codocenza)
Hours	25 ore (Codocenza) - Antonio Pierini
Learning activities	Altro
Area	Tirocini formativi e di orientamento
Academic discipline	MED/09
Type of study-unit	Obbligatorio (Required)

PROFESSIONALISING TRAINING IN MOLECULAR MEDICINE

Code	GP004825
CFU	1
Teacher	Roberta La Starza
Teachers	Roberta La Starza
Hours	25 ore - Roberta La Starza
Learning activities	Altro
Area	Tirocini formativi e di orientamento
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Introduction to technologies used to study the genome, DNA methylation, and histone methylation. Protocols and their applications. Diagnostic algorithms aimed at classification of human malignancies and identification of diagnostic and predictive markers.
Reference texts	None.
Educational objectives	Ability to address diagnostic investigations and optimize procedures.
Prerequisites	Knowledge of the genetic basis of tumors.
Teaching methods	Tutor system in working groups.
Other information	None.
Learning verification modality	During the exam.
Extended program	Conventional cytogenetics. FISH, SNPa, RNA microarray, PCR, sequencing, sanger sequencing and NGS. Telomeres, Chromosomal instability test. Test on paraffin sections. Nucleic acids, separation. Microarrays.
Obiettivi Agenda 2030 per lo sviluppo sostenibile	3 - Health

PROFESSIONALISING TRAINING IN REUMATHOLOGY

Code	GP005903
CFU	1
Teacher	Carlo Perricone
Teachers	Carlo Perricone
Hours	25 ore - Carlo Perricone
Learning activities	Altro
Area	Tirocini formativi e di orientamento
Academic discipline	MED/16
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	To: Describe the degenerative, autoimmune and inflammatory pathologies of the musculoskeletal system; Analyze the main signs and symptoms related to rheumatic diseases; Identify the diagnostic and assistance pathway of subjects suffering from rheumatologic diseases; Describe the implications of the management of therapeutic agents for rheumatological diseases
Reference texts	Reumatologia. Per studenti e medici di medicina generale a cura di UNIREUMA. IDELSON GNOCCHI IV Ed. 2022.
Educational objectives	At the end of the internship the student must be able to perform a clinical reasoning for diagnostic purposes on the basis of the clinical cases addressed. He must therefore be able to recognize: - The most common rheumatic diseases; - Less common rheumatic disorders that require urgent recognition (example: polymyalgia rheumatica); - Rheumatic diseases of social importance both in terms of diffusion and costs, on which it is possible to intervene with prevention and/or timely recognition (example: rheumatoid arthritis); Must know and interpret: - The significance of the signs and symptoms of rheumatological diseases for general diagnostic purposes as well as their pathogenetic mechanisms; - The main laboratory tests specific to these pathologies and the most common instrumental methods used in rheumatology.
Prerequisites	In order to start the Rheumatology internship, the student should have good knowledge of anatomy and good practice in the general physical examination of the patient.
Teaching methods	The internship includes 25 hours of practical lessons through participation to clinical activities and discussion of clinical cases with tutors.
Other information	Overarching objectives are to carry out a clinical reasoning for diagnostic and therapeutic purposes on the basis of the clinical cases faced.
Learning verification modality	For the professional internship there is no specific exam, but this is included in the final oral exam. The ability to autonomously carry out clinical reasoning for diagnostic purposes will be verified. Doctor-patient communication skills and the appropriateness of scientific language will also be assessed.
Extended program	The internship program includes participation in clinical activity and discussion of clinical cases at the Rheumatology Unit.
Obiettivi Agenda 2030 per lo sviluppo sostenibile