Unit SYSTEMIC PATHOLOGY V

BLOOD DISEASES - MOD. 1

Code	GP004821
Location	TERNI
CFU	2
Teacher	Arcangelo Liso
Teachers	Arcangelo Liso
Hours	25 ore - Arcangelo Liso
Learning activities	Caratterizzante
Area	Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)

BLOOD DISEASES - MOD. 2

Code	GP004822
Location	TERNI
CFU	1
Teacher	Arcangelo Liso
Teachers	Arcangelo Liso
Hours	12.5 ore - Arcangelo Liso
Learning activities	Caratterizzante
Area	Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)

DISEASES OF THE IMMUNE SYSTEM

Code	GP005900
Location	TERNI
CFU	2
Teacher	Antonio Pierini
Teachers	Antonio Pierini
Hours	25 ore - Antonio Pierini
Learning activities	Caratterizzante
Area	Medicina delle attività motorie e del benessere
Academic discipline	MED/09
Type of study-unit	Obbligatorio (Required)

MOLECULAR MEDICINE

Code	GP004823
Location	TERNI
CFU	1
Teacher	Roberta La Starza
Teachers	Roberta La Starza
Hours	12.5 ore - Roberta La Starza
Learning activities	Caratterizzante
Area	Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Technological approaches for genome study: cytogenetics, molecular cytogenetics, microarrays, NGS, WET assay. Leukemic and cancer stem cells, multistep process of oncogenesis; mechanisms of deregulation of oncogenes, oncosuppressors, repair genes and check-point genes. Basic principles of epigenetic regulation in DNA transcription and gene expression Hematopietic clonality, clonal hematopoiesis and human diseases, and pathogenesis of leukemias. Pathogenesis models of congenital and acquired bone marrow failures. Patterns of pathogenesis of acute leukemias. Function of tyrosine kinases. Models of pathogenesis of lymphoproliferative disorders. Models of pathogenesis of myeloma. Patterns of pathogenesis of solid tumors (central nervous system).
Reference texts	The material will be provided by professor.
Educational objectives	Learning study approaches for genetic and epigenetic characterization of blood diseases. Fundamental basis for understanding the processes of oncogenesis of major hematologic cancers.
Prerequisites	Basic concepts of molecular biology.
Teaching methods	Frontal lessons; Seminars.
Other information	None.
Learning verification modality	Multiple choice quiz or oral exam.
Extended program	Technological approaches for genome study: conventional cytogenetics, fluorescence in situ hybridization (interphase, metaphase, on tissue), multi-FISH, arrays on DNA and RNA, NGS targets. Characteristics of leukemic and cancer stem cell Study of the multistep process of oncogenesis, mechanisms of alteration of oncogenes, oncosuppressors, repair genes and check-point genes. Intratumoral heterogeneity, clonality, and subclonality of genomic alterations. Oncogenes and oncosuppressors: role and type of deregulation. Principles of epigenetic regulation, both at the transcriptional and post-transcriptional levels. Patterns of pathogenesis of congenital and acquired bone marrow failure. Patterns of pathogenesis of Acute and chronic Leukemias. Function and involvement of tyrosine kinases in human neoplasms. Pathogenesis models of Multiple Myeloma and Lymphomas. Patterns of pathogenesis of solid tumors (central nervous system).
Obiettivi Agenda 2030 per lo sviluppo sostenibile	3 - Health

REUMATHOLOGY

Code	GP005901
Location	TERNI
CFU	2
Teacher	Carlo Perricone
Teachers	Carlo Perricone
Hours	25 ore - Carlo Perricone
Learning activities	Caratterizzante
Area	Clinica delle specialità medico-chirurgiche
Academic discipline	MED/16
Type of study-unit	Obbligatorio (Required)

PROFESSIONALISING TRAINING IN BLOOD DISEASES

Code	GP004824
Location	TERNI
CFU	1
Teacher	Arcangelo Liso
Teachers	Arcangelo Liso
Hours	25 ore - Arcangelo Liso
Learning activities	Altro
Area	Tirocini formativi e di orientamento
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)

PROFESSIONALISING TRAINING IN DISEASES OF THE IMMUNE SYSTEM

Code	GP005902
Location	TERNI
CFU	1
Teacher	Antonio Pierini
Teachers	Antonio Pierini
Hours	25 ore - Antonio Pierini
Learning activities	Altro
Area	Tirocini formativi e di orientamento
Academic discipline	MED/09
Type of study-unit	Obbligatorio (Required)

PROFESSIONALISING TRAINING IN MOLECULAR MEDICINE

Code	GP004825
Location	TERNI
CFU	1
Teacher	Roberta La Starza
Teachers	Roberta La Starza
Hours	25 ore - Roberta La Starza
Learning activities	Altro
Area	Tirocini formativi e di orientamento
Academic discipline	MED/15
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Introduction to technologies used to study the genome, DNA methylation, and histone methylation. Protocols and their applications. Diagnostic algorithms aimed at classification of human malignancies and identification of diagnostic and predictive markers.
Reference texts	None.
Educational objectives	Ability to address diagnostic investigations and optimize procedures.
Prerequisites	Knowledge of the genetic basis of tumors.
Teaching methods	Tutor system in working groups.
Other information	None.
Learning verification modality	During the exam.
Extended program	Conventional cytogenetics. FISH, SNPa, RNA microarray, PCR, sequencing, sanger sequencing and NGS. Telomeres, Chromosomal instability test. Test on paraffin sections. Nucleic acids, separation. Microarrays.
Obiettivi Agenda 2030 per lo sviluppo sostenibile	3 - Health

PROFESSIONALISING TRAINING IN REUMATHOLOGY

Code	GP005903
Location	TERNI
CFU	1
Teacher	Carlo Perricone
Teachers	Carlo Perricone
Hours	25 ore - Carlo Perricone
Learning activities	Altro
Area	Tirocini formativi e di orientamento
Academic discipline	MED/16
Type of study-unit	Obbligatorio (Required)