Unit BIOCOMPATIBLE MATERIALS, BIOMASS AND SUSTAINABILITY

BIOCOMPATIBLE MATERIALS FOR BIOTECHNOLOGY APPLICATIONS

Code	A003502
CFU	6
Teacher	Assunta Marrocchi
Teachers	Assunta Marrocchi
Hours	42 ore - Assunta Marrocchi
Learning activities	Caratterizzante
Area	Discipline chimiche e chimico-industriali
Sector	CHIM/06
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Biomaterials & Biocompatibility. Polymeric, ceramic and metallic biomaterials. Composites. Analytical methods for biomaterials surface characterization. Surface modification of biomaterials. Established biomaterials-based technologies. Bioelectronics.
Reference texts	Teaching material will be provided by the lecturer. Additional reference texts and selected readings will be suggested during the course and will be available through the ProQuest platform, to which the University of Perugia provides access.
Educational objectives	The main objective of the course is to provide to students the basic knowledge about chemical-physical aspects and the development of biocompatible materials, to rationally elaborate selection criteria for their design/use in the fields of application discussed during lectures. The main knowledge acquired will be: -knowledge of (i) definition of biomaterial and biocompatibility (ii) definition of solid state, main crystalline networks and their principal defects; -basic knowledge of the electrical, optical, thermal properties of solid materials; -knowledge of the fundamental concepts of stress, strain, rigidity, resistance, toughness of biocompatible materials; -knowledge of the main classes of biocompatible materials: Polymers (classification on the basis of their chemical-physical and mechanical properties; polymerization reactions; main classes of interest); Ceramics and glass-ceramics (traditional and advanced materials); Metals and alloys; Composites; -basic knowledge of their main production techniques and influence of these latter on the operational material behavior; -knowledge of the biomaterials corrosion phenomena in a biological environment and relative issues; -knowledge of the main instrumental techniques for the study of biomaterials surface, to evaluate their biocompatibility; -knowledge of the main techniques for biomaterials surface modification, to adjust biocompatibility; -basic knowledge of selected biomaterials-based sensors for application in medical and biological field. The main abilities will be: -ability in elaborating criteria of choice for the design and synthesis of 3D structures to be employed in the field discussed during lectures. -ability in identifying the most suitable instrumental techniques for the characterization of biomaterials surfaces, in view of evaluating their biocompatibility -ability in identifying the most suitable techniques for biomaterials surface modification, in view of improving their biocompatibility.
Prerequisites	none
Teaching methods	Face-to-face lectures on all the topics of the course. During the course there might be the possibility to organize seminars in which external experts will report about their practical experience on the use of advanced instrumental techniques for the study of biomaterials surfaces.
Other information
Learning verification modality	The course constitutes a module of the integrated course 'BIOMATERIALS, BIOMASSES, AND SUSTAINABILITY.' It is worth noting that the final assessment for learning remains the same for both modules that make up the integrated course, although partial assessments are possible. In the specific case of this module, the partial assessment consists of an oral examination. This examination involves a discussion lasting approximately 30 minutes, aimed at evaluating the level of competence and knowledge acquired by the student regarding the program's content. Furthermore, through the oral examination, the student's ability to analyze the same content will be assessed, both in terms of language proficiency and presentation organization. Both the knowledge and skills acquired and the ability to analyze the content discussed in class are considered essential for the students' professional development. Students with disabilities and/or specific learning disabilities (SLD) are invited to visit the dedicated page on the tools and measures provided and to prearrange any necessary accommodations with the instructor (https://www.unipg.it/disabilita-e-dsa)
Extended program	Biomaterials & Biocompatibility. Reference to the main types of chemical bonding. Solid state. Solid materials properties (mechanical, thermal, optical). Polymeric, ceramic/glass-ceramic and metallic biomaterials: classification, synthesis, production tecniques, main classes of interest. (nano)Composites. Established biomaterials-based technologies. Main analytical methods for biomaterials surface characterization. Surface modification of biomaterials. Bioelectronics. Other emerging and future biomaterials-based technologies. Reference to the existing normative.
Obiettivi Agenda 2030 per lo sviluppo sostenibile	3, 9

SUSTAINABLE BIOMASS TRANSFORMATION PROCESSES

Code	A003503
CFU	6
Teacher	Luca Sancineto
Teachers	Assunta Marrocchi (Codocenza)
Hours	42 ore (Codocenza) - Assunta Marrocchi
Learning activities	Caratterizzante
Area	Discipline chimiche e chimico-industriali
Sector	CHIM/06
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Renewable resources for processes to access energy, fine chemicals and plastics: Biomass. Biomass types. Biorefineries. Processes for the biomass valorization finalized to the preparation of biofuels, bio-chemicals, bioplastics. Green chemistry and biorefineries. Alternative solvents. Heterogenized and heterogeneous catalysts. Microwaves as alternative heating source. Renewables industries: some examples.
Reference texts	Teaching material will be provided by the lecturer. Additional reference texts and selected readings will be suggested during the course and will be available through the ProQuest platform, to which the University of Perugia provides access.
Educational objectives	At the end of the course, students will have acquired basic knowledge on chemical processes for biomass valorisation within the biorefinery concept, with particular reference to the production of energy, chemicals and bioplastics from platform molecules. Students are expected to be able to apply the principles of green chemistry to the conceptual design of biomass conversion processes, with attention to eco-compatible strategies, solvent and catalyst selection, energy sources and sustainability metrics. The course aims to provide students with the ability to critically evaluate different chemical process options for biomass conversion, considering efficiency, sustainability and potential industrial application, without focusing on biotechnological or plant-scale aspects. Through the discussion of industrial examples, students will be able to analyse case studies related to biomass valorisation and understand the main chemical and process choices adopted.
Prerequisites	The course is designed to be fully accessible regardless of attendance of related elective courses.
Teaching methods	Face-to-face lectures on all the topics of the course
Other information
Learning verification modality	The course is part of the integrated program 'BIOMATERIALS, BIOMASSES, AND SUSTAINABILITY.' It should be noted that the final assessment of learning remains the same for both modules that make up the integrated course, although partial assessments are possible. In the specific case of this module, the partial assessment consists of an oral examination. This examination involves a discussion lasting approximately 30 minutes, aimed at assessing the level of competence and knowledge achieved by the student regarding the program's content. Furthermore, through the oral examination, the ability to process the same content will be evaluated, both in terms of language proficiency and presentation organization. Both the knowledge and skills acquired and the ability to process the content discussed in class are considered essential for the professional development of students. Students with disabilities and/or specific learning disabilities (SLD) are invited to visit the dedicated page outlining the tools and measures provided and to coordinate any necessary accommodations in advance with the instructor (https://www.unipg.it/disabilita-e-dsa).
Extended program	Introduction. Renewable resources for processes to access energy, fine chemicals and plastics: Biomass. Biomass types. Major vegetal biomass components. Biorefineries. Chemical processes for the biomass valorization finalized to the preparation of biofuels, bio-chemicals, bioplastics via “platform molecules”. Green chemistry and biorefineries. The 12 Green Chemistry principles. Metrics. Main strategies for the realization of eco-compatible chemical processes for biomass transformation. Alternative solvents: water, immobilized solvents, ionic liquids and eutectic mixtures, biomass-derived solvents, solvent-free conditions, supercritical fluids. Heterogenized and heterogeneous catalysts. Microwaves as alternative heating source. Renewables industries: some examples.
Obiettivi Agenda 2030 per lo sviluppo sostenibile	7,9,12