Unit TOXICOLOGY
- Course
- Pharmacy
- Study-unit Code
- 65258708
- Location
- PERUGIA
- Curriculum
- In all curricula
- Teacher
- Massimo Allegrucci
- Teachers
-
- Massimo Allegrucci
- Massimo Allegrucci
- Hours
- 56 ore - Massimo Allegrucci
- 10 ore - Massimo Allegrucci
- CFU
- 8
- Course Regulation
- Coorte 2015
- Offered
- 2018/19
- Learning activities
- Caratterizzante
- Area
- Discipline biologiche e farmacologiche
- Academic discipline
- BIO/14
- Type of study-unit
- Obbligatorio (Required)
- Type of learning activities
- Attività formativa monodisciplinare
- Language of instruction
- Italian
- Contents
- Principles of Toxicology. Mutagenesis. Carcinogenesis. Teratogenesis. Adverse reactions to drugs and herbal remedies. Definitions, classification of ADRs. Pharmacovigilance of drug and herbal medicine. Pharmacogenetics e Toxicogenetics. Detoxification of xenobiotics. Substance abuse. Drugs and pregnancy. Toxicology of prions. QT prolongation.
- Reference texts
- 1. Droghe e farmaci psicoattivi
Robert M. Julien, Claire D. Advokat, Joseph E. Comaty
Zanichelli, 2012 - 688 pagine
2. Tossicologia. Principi e applicazione all'uso dei farmaci e dei prodotti della salute
Piera Ghi, Massimo Allegrucci, Antonello Di Paolo
Minerva Medica, 2009 - Medical - 304 pages
3. Casarett & Doull Elementi di Tossicologia
A cura di Patrizia Hrelia, Giorgio Cantelli Forti
Casa Editrice Ambrosiana. Distribuzione esclusiva Zanichelli
2013 - Educational objectives
- The aim is to transfer to future pharmacists the basics of toxicological knowledge necessary for the proper use and dispensing of drugs, herbal remedies, and related products.
- Prerequisites
- in order to be able to understand and apply the knowledge and methodology described within the course the student must have passed the Biology, Biochemistry and General Pharmacology exams.
- Teaching methods
- Seminar lectures with audiovisual material in order to engage students in a general discussion.
all the course material in digital format is made available at the first lesson - Other information
- Discussion of clinical cases of adverse drug reactions with the aim to describe the involved mechanism and the risk management.
- Learning verification modality
- The exam consists of an oral test about the issues proposed during the class.
In order to put the student at ease the test begins with a subjet of his chose.
The duration of the test depend on the performance of the student, but is never less than 30 minutes - Extended program
- Principles of Toxicology: subjects of toxicology, exposure characteristics, risk assessment, types of adverse effects. Dose-response relationships, threshold effects, non-threshold effects, hormesis.
Mutagenesis: types of mutations, repair systems.
Carcinogenesis: stages of carcinogenesis, oncogenes and tumor suppressor genes: p53 ras and
Teratogenesis, major teratogenic substances: thalidomide, DES and alcohol.
Adverse reactions to drugs and herbal remedies .
Definitions, classification of ADRs.
Pharmacovigilance of drug and herbal medicine. Pharmacogenetics, Toxicogenetics.
Detoxification of xenobiotics, detoxification mechanisms, genetic polymorphisms.
Substance abuse. Drugs and pregnancy. Toxicology of prions. QT prolongation.