Unit PHYSIOPATHOLOGICAL BASES OF DISEASES

CLINICAL PHARMACOLOGY

Code	GP003702
CFU	2
Teacher	Simona Ronchetti
Teachers	Simona Ronchetti
Hours	24 ore - Simona Ronchetti
Learning activities	Base
Area	Primo soccorso
Academic discipline	BIO/14
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Basic principles of common features of drugs: pharmacokinetics, pharmacodynamics. Special pharmacology on analgesic and anti-inflammatory drugs.
Reference texts	Farmacologia Generale e Speciale per le lauree sanitarie, a cura di Silvano Gabriele Cella - Anna Maria Di Giulio - Alfredo Gorio - Francesco Scaglione, Università degli Studi di Milano; Piccin. Pharmacology for Rehabilitation Professionals; Barbara Gladson; second edition; Elsevier Saunders
Educational objectives	Acquiring knowledge on efficient and safe administration of drugs; knowledge on pharmacological and side effects of analgesic and anti-inflammatory drugs
Prerequisites	In order to fully understand and apply most knowledge of the course it is important and useful having successfully passed the following exams of the first semester, first year: "Molecular Biological Basis", "Morphological and Functional Basis", "Psycological-relational Basis" and "Promotion of health and safety". Students need, in fact, to know how cells, organs and systems works inside the human body and also to understand the meaning of the therapist care.
Teaching methods	class lessons and DVD projection
Other information	Frequenza: compulsory Location: Via Oberdan, 123 - Foligno (PG) - classrooms of the in rehabilitation therapy course degree.
Learning verification modality	The exam is made by both a written and an oral exam. The written exam is on microbiology issues and is by questions with multiple choices. Ones the written exam is passed, the student can take the oral exam with questions on pharmacology and pathology. The oral exam consists in a discussion of about 30 minutes. During this discussion the student must show to have reached a good level of knowledge and comprehension on theory and methods of the programs. The oral exam will evaluate also the communication, the language and the autonomy skills of the students. Students can be driven, during the exam, by figures showed in the class lessons. All considered, the exam allows to know the ability to learn, the level of knowledge and the critical ability of the students, beside their capacity to talk and to apply learned knowledge.
Extended program	General pharmacology: Orientation to pharmacology Regulation, development, names and update on drugs Pharmacokinetics Pharmacodinamics Special Pharmacology: Principles of pain pharmacology Non-steroidal anti-inflammatory drugs (NSAIDs) Opioid drugs Local Aenestetics Pharmacology of inflammation: Glucocorticoids

MICROBIOLOGY

Code	GP003701
CFU	1
Teachers	Claudia Monari (Codocenza)
Hours	12 ore (Codocenza) - Claudia Monari
Learning activities	Affine/integrativa
Area	Attività formative affini o integrative
Academic discipline	MED/07
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Notions concerning: structure and physiology of bacteria, viruses, fungi, parasites, host-microorganism interaction; mechanisms of microbial pathogenicity. Information on the main pathogenic microorganisms for humans and associated diseases.
Reference texts	Microbiologia Clinica. Eudes Lanciotti. (Casa Editrice Ambrosiana) Antonelli e al. Principi di microbiologia medica (Zanichelli)
Educational objectives	Basic microbiology knowledge
Prerequisites	Knowledge that the student must possess at the beginning of the teaching lessons in order to understand the contents treated and the learning objectives: anatomy - important immunology - useful biology - useful general pathology - useful
Teaching methods	Frontal lessons
Other information	Frequenza obbligatoria
Learning verification modality	Oral examination For information on support services for students with disabilities and / or DSA visit the page:http://www.unipg.it/disabilita-e-dsa
Extended program	Bacteriology: bacteria morphology, structure and function - Bacterial metabolism - Bacterial observation and culture - Bacterial pathogenesis mechanisms - Bacterial taxonomy Main pathogenic bacteria for humans. Virology: virus morphology, structure and function - Viral replication - Virus observation and cultivation - Viral pathogenesis mechanisms - Virus classification Main pathogenic viruses for humans Mycology: morphology, structure and function of mycetes. Metabolism of mycetes - Observation and cultivation of mycetes Host-microorganism interaction and mechanisms of pathogenicity of mycetes- Classification of mycetes. Parassitology: morphology, structure and function of parasites Sterilization and disinfection. Infections of the apparatus of the human body

GENERAL PATHOLOGY

Code	GP003703
CFU	2
Teachers	Andrea Bartoli (Codocenza)
Hours	24 ore (Codocenza) - Andrea Bartoli
Learning activities	Base
Area	Scienze biomediche
Academic discipline	MED/04
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	The essential elements of the course are: - molecular pathology - major genetic diseases - diseases from environmental causes - cellular pathology and cell death - Inflammation - Molecular Oncology - Elements of the pathophysiology of the organs and systems
Reference texts	1. G.M. Pontieri. Patologia e fisiopatologia generale. Per i corsi di laurea in professioni sanitarie. Piccin 2.Spector. Introduzione alla Patologia Generale, Casa editrice Ambrosiana 3. Pontieri. Patologia generale, Piccin 4. Robbins. Le basi patologiche delle malattie, Elsevier
Educational objectives	At the end of the course is expected that students have acquired basic knowledge to understand the molecular moments pertaining to the etiopathogenesis of disease, as well as have knowledge of the main aspects of the pathophysiology of organs and systems.
Prerequisites	In order to fully understand and apply most knowledge of the course it is important and useful having successfully passed the following exams of the first semester, first year: "Molecular Biological Basis", "Morphological and Functional Basis", "Psycological-relational Basis" and "Promotion of health and safety".  Students need, in fact, to know how cells, organs and systems works inside the human body and also to understand the meaning of the therapist care.
Teaching methods	Face to face lectures. The lectures deal the whole program of the course of study, but also specialized topics that emerge from the specific needs of learners, all in view of a highly vocational pourpose. Each lesson has a duration of two hours when it faced a specific subject, related to others already exposed, to allow the student to have an integrated vision.
Other information
Learning verification modality	The exam is made by both a written and an oral exam. The written exam is on microbiology issues and is by questions with multiple choices.  Ones the written exam is passed, the student can take the oral exam with questions on pharmacology and pathology.  The oral exam consists in a discussion of about 30 minutes.  During this discussion the student must show to have reached a good level of knowledge and comprehension on theory and methods of the programs.  The oral exam will evaluate also the communication, the language and the autonomy skills of the students.  Students can be driven, during the exam, by figures showed in the class lessons. All considered, the exam allows to know the ability to learn, the level of knowledge and the critical ability of the students, beside their capacity to talk and to apply learned knowledge.
Extended program	1. Introduction. The field of interest of the general pathologist. Meaning of general pathology in life sciences, medical and biotechnology. 2. The communication between cells. The structural basis of communication. The cell signaling: endocrine, autocrine and paracrine. The interactions between cells and matrix. Pathology of cellular signaling. 3. The cell damage and adaptive mechanisms. Causes of cell damage. Mechanisms of cell damage. Morphological aspects of cell damage. The subcellular response to injury. The cellular adaptation. Hypertrophy and atrophy. 4. The acute and chronic inflammation. Acute inflammation. Vascular changes. Cellular events: the exudation and leukocyte phagocytosis. The chemical mediators of inflammation. Chronic inflammation: definition and causes. The role of the lymphatic system and lymphoid tissue in inflammatory processes. Systemic manifestations of the inflammatory process. 5. The repair processes. The cell cycle control and cell proliferation. The repair scar. Mechanisms of wound healing. Pathology of the healing process. Integration of inflammatory and reparative processes. 6. Genetic diseases. Mendelian diseases. Polygenic diseases. Cytogenetic disease. The molecular diagnosis of genetic diseases. 7. Diseases from environmental causes. Environmental pollution. Damage to chemical and physical agents. Nutritional diseases. Infectious diseases. 8. Neoplasia and cell transformation. Definitions and nomenclature. Characteristics of benign and malignant. The malignancies. Epidemiology of cancer. Carcinogenesis and the molecular basis of cancer. Biology of the neoplastic proliferation. Etiology of cancer: carcinogens. Host defenses against cancer. The immunity to tumors. Clinical features of malignancy. 9. Essentials of pathophysiology of the endocrine system 10. Essentials of pathophysiology of the cardiovascular system 11. Essentials of pathophysiology of the liver 12. Essentials of pathophysiology of the respiratory tract 13. Essentials of Pathophysiology urogenital apparatus