Unit ORGANIC CHEMISTRY
- Course
- Pharmacy
- Study-unit Code
- 65005110
- Location
- PERUGIA
- Curriculum
- In all curricula
- Teacher
- Massimo Curini
- Teachers
-
- Massimo Curini
- Daniela Lanari (Codocenza)
- Daniela Lanari
- Hours
- 42 ore - Massimo Curini
- 21 ore (Codocenza) - Daniela Lanari
- 20 ore - Daniela Lanari
- CFU
- 9
- Course Regulation
- Coorte 2016
- Offered
- 2017/18
- Learning activities
- Base
- Area
- Discipline chimiche
- Academic discipline
- CHIM/06
- Type of study-unit
- Obbligatorio (Required)
- Type of learning activities
- Attività formativa monodisciplinare
- Language of instruction
- Italian
- Contents
- Structure of organic molecules, nomenclature, synthesis and reactivity of functional groups, notions of stereochemistry, major reaction mechanisms.
- Reference texts
- CHIMICA ORGANICA 5e EdiSES, Brown, Foote, Iverson, Anslyn;
- Educational objectives
- Knowledge of the basics of organic chemistry, nomenclature of organic compounds, reactions that characterize the synthesis and chemistry of the main functional groups with reference also to the stereochemical aspect. Being able to apply the principles acquired also to the study of molecules of biochemical and pharmaceutical interest.
- Prerequisites
- The student should be familiar with the basic notions of general chemistry in particular must have passed the exam of General Chemistry and Analytical Chemistry
- Teaching methods
- Frontal lectures where the professor will present all the topics of the course, and teach a correct approach to the type of study required, during the lessons there will be frontal exercises where students will be asked to solve problems with the professor.
- Learning verification modality
- The student will be assessed through a written and oral test. The written test will consist in providing the correct nomenclature and configuration of organic molecules and resolution of exercises where it will be required to know how to use the notions learned on synthesis and reactivity. The oral examination will consist of a discussion of the written test and a further evaluation of the student through questions to determine the degree of familiarity with the topics dealt with during the course.
- Extended program
- Organic molecule structureAtomic Orbital and Electronic Configuration, Chemical Bonding, Lewis Formulas, Molecular and Hybrid Orbitals, Bond Polarity, Intramolecular Forces, Electrophilic and Nucleophilic Concept, Carboanion Carbocation, Constitutional IsomerismAcids and basesDefinition of acids and bases according to Brönsted and Lewis; Acid-base equilibria; PKa valuesAlkanes and cycloakanesNomenclature and chemical-physical properties, conformational analysis, radical halogenation.The stereoisomerismChiralityconcept, diasteroisomers and enantiomers, racemic mixtures, stereochemical descriptors (R, S), polarimetry, stereoselective and stereospecific reactions.AlkenesNomenclature and physical-chemical properties, cis, trans, E / Z isomers, Markovnikov rule, Hammond's postulate. Double-bond electrophilic addition reactions, transposition of carbocation.AlkynesNomenclature and chemical-physical properties, acidity and reactivityProperties and reactions of alogenoalkanesNomenclature and physical-chemical properties, SN2 and SN1 substitution reactions, E2, E1, Saytzev and Hoffmann rule parameters that influence the reaction rate of substitution and elimination.Alcohols and thiolsNomenclature and chemical-physical properties, hydrogen bond and acidity, alcohol synthesis: use of organometallic reagents and alcohol reactivity: nucleophilic oxidation and sustitutionEthers and thioethersNomenclature and chemical-physical properties, regio-and stereoselectivity in the ring opening of epoxidesAldehydes and ketonesNomenclature and physical-chemical properties, synthesis and reactivity, acylic nucleophilic addition, keto-enolic tautomeria, oxidation and reduction, acidity of alpha hydrogen, enolate ions reactions.Carboxylic acidsNomenclature and chemical-physical properties, acidity, synthesis, reactivity: nucleophilic acylic substitution, synthesis of functional derivatives of carboxylic acidsFunctional derivatives of carboxylic acidsNomenclature and chemical-physical properties, reactivity of anhydrides, phosphoric anhydrides of acyl halides, amides and lactames, esters and thioesters, nitriles, ¿-delocalized systems:Chemistry of the 2-propenyl (allyl) system, conjugated dienes: addition reactions 1,2 and 1,4 Bifunctional systemsAlpha ,beta-unsaturated carbonyls, alpha- and beta-dicarbonyl compounds, activated methylene reactivity.Benzene and aromaticity conceptAromaticity. Resonance energy aromatic electrophilic substitution. Mechanism, regioselectivity, activation and deactivation of the substrate, effect of the major substitutes. Aromatic nucleophilic substitution: hints. Phenols and quinones.AminesNomenclature and chemical-physical properties, basicity, synthesis of aliphatic and aromatic amines, reactivity, diazonium salts: synthesis and use.