Unit DRUG ANALYSIS II
- Course
- Pharmacy
- Study-unit Code
- 65013406
- Location
- PERUGIA
- Curriculum
- In all curricula
- Teacher
- Roccaldo Sardella
- CFU
- 6
- Course Regulation
- Coorte 2016
- Offered
- 2017/18
- Learning activities
- Caratterizzante
- Area
- Discipline chimiche, farmaceutiche e tecnologiche
- Academic discipline
- CHIM/08
- Type of study-unit
- Obbligatorio (Required)
- Type of learning activities
- Attività formativa monodisciplinare
DRUG ANALYSIS II - Cognomi A-L
| Code | 65013406 |
|---|---|
| Location | PERUGIA |
| CFU | 6 |
| Teacher | Roccaldo Sardella |
| Teachers |
|
| Hours |
|
| Learning activities | Caratterizzante |
| Area | Discipline chimiche, farmaceutiche e tecnologiche |
| Academic discipline | CHIM/08 |
| Type of study-unit | Obbligatorio (Required) |
| Language of instruction | Italian |
| Contents | Fundamentals of the quantitative analysis of drugs; Technique of volumetric analysis: Acidimetry and alkalimetry in aqueous and non-aqueous solvent; complexometric titrations; Argentimetric titrations; Oxidation-reduction titrations; Potentiometric titrations; Spectrophotometric determinations; Examples of quantitative analysis of drugs reported in the European Pharmacopoeia. |
| Reference texts | Italian Pharmacopoeia - G.C. PORRETTA, Analisi di preparazioni farmaceutiche, casa editrice C.I.S.U. - D.A. SKOOG, D.M. WEST, F.J. HOLLER, S.R. CROUCH, Fondamenti di chimica analitica, casa editrice EdiSES |
| Educational objectives | The main aim of this teaching is to provide the main knowledge concerning the analytical techniques needed for the quantitative analysis of compounds of biological and pharmaceutical interest. The main skills acquired in laboratory will allow the student to perform the quantitative determinations through the methods of acid-base, precipitation, complexometric, and redox based titration. |
| Prerequisites | Propedeuticity General chemistry Mathematics and elements of computer science Inorganic and analytical chemistry |
| Teaching methods | The course is organized as follow: Lectures on all the subject of the course. Laboratory exercises at the “Analisi quantitativa-volumetrica dei Medicinali” lab. Students will be divided into groups (maximum 32 students per group) and each group will follow 10 experiences of about 4 hours each. |
| Other information | Obligatory attendance Dipartimento di Scienze Farmaceutiche Sezione di Chimica e Tecnologia del Farmaco Via del Liceo, 1 06123 - Perugia |
| Learning verification modality | Laboratory reports Oral exam |
| Extended program | The course is organized in lectures and experimental exercises: Theoretical part: General analytical methods. Analytical procedure. Balances (notes). The error in Analytical Chemistry: Accuracy and precision - Error types - Determination of the accuracy and reproducibility of the analytical method - Elements of statistics for data manipulation - Significant figures. Standard solutions. Primary standard. Acid-base titrations: construction of the titration curve. Choice of the appropriate indicator. Alkalimetry and Acidimetry. Acid-base titration in non-aqueous solvent. Solvents classification. Diversifying and leveling effect of the solvent. Titrations with formation of precipitate. Argentometric. Complexometric titrations. Monodentate and polydentate ligands. EDTA. Effect of pH on the complexation reactions with EDTA. Titration with EDTA: direct displacement and replacement. Metallochromic indicators. Titrations with electron transfer. Standard potentials. Nernst equation. Permanganometry. Cerimetry. Bromometry. Oxidimetry with dichromate. Iodometry and Iodimetry. Redox indicators. Potentiometry. Reference electrodes and electrode indicators. Potentiometric titrations acid-base and redox. Spectrophotometric determinations. Experimental part: Quantitative determination of drugs according to the Official Pharmacopoeia. Quantitative determination of drugs by using the instrumental methods described in the theoretical part. |
DRUG ANALYSIS II - Cognomi M-Z
| Code | 65013406 |
|---|---|
| Location | PERUGIA |
| CFU | 6 |
| Teacher | Serena Massari |
| Teachers |
|
| Hours |
|
| Learning activities | Caratterizzante |
| Area | Discipline chimiche, farmaceutiche e tecnologiche |
| Academic discipline | CHIM/08 |
| Type of study-unit | Obbligatorio (Required) |
| Language of instruction | Italian |
| Contents | Theoretical aspects of the reactions of volumetric neutralization carried out through acid-base titrations, precipitation, complexometric, and redox based reactions. Laboratory exercises aimed to the accomplishment of quantitative-volumetric analysis: acid-base titrations, precipitation, complexometric, and redox based reactions. |
| Reference texts | Lecture notes, Official Italian Pharmacopoeia, XII Edition. G.C. PORRETTA, Analisi di preparazioni farmaceutiche, casa editrice C.I.S.U. D.A. SKOOG, D.M. WEST, F.J. HOLLER, S.R. CROUCH, Fondamenti di chimica analitica, casa editrice EdiSES. Na Li, John J. Hefferen, Ke’an Li. Quantitative chemical analysis. WORLD SCIENTIFIC - PEKING UNIVERSITY PRESS 2013 |
| Educational objectives | The main aim of this teaching is to provide the main knowledge concerning the analytical techniques needed for the quantitative analysis of compounds of biological and pharmaceutical interest. The main skills acquired in laboratory will allow the student to perform the quantitative determinations through the methods of acid-base, precipitation, complexometric, and redox based titration. |
| Prerequisites | In order to be able to understand and apply the majority of the techniques described within the course, it is necessary to have successfully passed the exams of "Chimica Generale" and "Chimica Inorganica e Analitica". Moreover, other topics matter of the course require to have fully frequented the course of "Analisi dei Medicinali I". |
| Teaching methods | Laboratory exercises at the “Analisi quantitativa-volumetrica dei Medicinali” lab. Students will be divided into groups (maximum 32 students per group) and each group will follow 10 experiences of about 4/5 hours each. |
| Other information | Department of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section Via del Liceo, 1 06123-Perugia |
| Learning verification modality | The exam consists of an oral test and of the evaluation of the reports for the experiments and laboratory procedures carried out during the course. Oral exam consists of an interview of about 30 minutes long, aimed at ascertain the knowledge level and the understanding capability acquired by the student on theoretical and methodological contents as indicated in the program. The oral exam will also test the student communication skills and his autonomy in the organization and exposure of the theoretical topics. At the end of each laboratory experience (10 practical experiences), the student has to draw up and deliver a detailed report related to the experiment carried out. In the report, the student has to describe the methods and techniques used, the chemical reactions at the base of the experiment, and the stoichiometric calculations necessary to obtain the final result. The reports evaluation will be communicated to the student during the oral exam. |
| Extended program | The course is organized in lectures and experimental exercises: Theoretical part: General analytical methods. Analytical procedure. Balances (notes). The error in Analytical Chemistry: Accuracy and precision - Error types - Determination of the accuracy and reproducibility of the analytical method - Elements of statistics for data manipulation - Significant figures. Standard solutions. Primary standard. Acid-base titrations: construction of the titration curve. Choice of the appropriate indicator. Alkalimetry and Acidimetry. Acid-base titration in non-aqueous solvent. Solvents classification. Diversifying and leveling effect of the solvent. Titrations with formation of precipitate. Argentometric. Complexometric titrations. Monodentate and polydentate ligands. EDTA. Effect of pH on the complexation reactions with EDTA. Titration with EDTA: direct displacement and replacement. Metallochromic indicators. Titrations with electron transfer. Standard potentials. Nernst equation. Permanganometry. Cerimetry. Bromometry. Oxidimetry with dichromate. Iodometry and Iodimetry. Redox indicators. Potentiometry. Reference electrodes and electrode indicators. Potentiometric titrations acid-base and redox. Experimental part: Quantitative determination of drugs according to the Official Pharmacopoeia. Quantitative determination of drugs by using the instrumental methods described in the theoretical part. |