Chemical sciences
Study-unit Code
Chimica organica
Luigi Vaccaro
  • Luigi Vaccaro
  • Francesco Ferlin (Codocenza)
  • 42 ore - Luigi Vaccaro
  • 24 ore (Codocenza) - Francesco Ferlin
Course Regulation
Coorte 2022
Learning activities
Discipline chimiche organiche
Academic discipline
Type of study-unit
Obbligatorio (Required)
Type of learning activities
Attività formativa monodisciplinare
Language of instruction

The course deals with the most common methods of synthetic methodologies used to understand the reactivity of organic molecules and to design the synthesis of commonly used molecules both in academic and industrial
Reference texts

Those attending will be provided, electronically, with the same material used by the lecturer for classroom lessons.
A representative text of reference is:
Advanced Organic Chemistry, 2007 Ed
AUTHORS: Carey, Francis A., Sundberg, Richard J. Part A: Structure and Mechanisms
Part B: Reaction and Synthesis
Educational objectives

The course should demonstrate to the student the importance of the fundamental synthetic methodologies to understand the reactivity of organic molecules and to design the synthesis of commonly used molecules both in academic and industrial

The course should allow the student to acquire the following basic knowledge:
Know stereoselectivity in reactions
Understand the fundamental methods of oxidation of organic molecules
Know the basic methods of reducing the organic molecules
Know the fundamental chemistry of carbanions and organometallic reagents
Know the key processes used in modern production such as enantioselective oxidations and methodologies for process optimization

Knowledge of basic organic chemical elements is required (Organic Chemistry I and II).
Teaching methods

The course provides theoretical frontal lessons and practical examples, to facilitate the student in learning modern techniques of chemical process optimization.
In the lessons of 2 hours each, held in the classroom, the principles of Organic Synthesis will be illustrated and some chemical issues will also be introduced to better understand the practical examples.
Other information

Learning verification modality

The proof of profit includes the assessment of written reports on laboratory activities and an oral test, which will involve the formulation of 4-5 questions over a period of approximately 40 minutes. The test is aimed at assessing students' abilities and assessing the environmental impact of a chemical process and distinguishing the various factors that influence it.
The overall evaluation of the exam will take into account the following aspects: correctness and adequacy of responses, processing skills and conceptual connection, mastery and language skills, according to the following percentages: 60%, 20%, 20%.
Extended program

The course includes theoretical frontal lessons

- Stereoselectivity in nucleophilic addition reactions to carbonyl functionality.
Rule of Cram, Karabatos, Felkin, Felkin-Anh
- Oxidation reactions (oxidation of various organic functions).
- Reduction reactions (reduction of various organic features).
- Carbanions in organic synthesis.
- Notes on organometallic compounds and their reactions
- Synthesis of Sertralin
- Synthesis of Talampanel
- Synthesis of Swainsonines
- Synthesis of Indinavir
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