Unit BIOTECHNOLOGICAL DRUGS
- Course
- Medical, veterinary and forensic biotechnological sciences
- Study-unit Code
- A001768
- Curriculum
- In all curricula
- Teacher
- Simona Ronchetti
- Teachers
-
- Simona Ronchetti
- Oxana Bereshchenko (Codocenza)
- Hours
- 40 ore - Simona Ronchetti
- 12 ore (Codocenza) - Oxana Bereshchenko
- CFU
- 6
- Course Regulation
- Coorte 2022
- Offered
- 2022/23
- Learning activities
- Caratterizzante
- Area
- Discipline medico-chirurgiche e riproduzione umana
- Academic discipline
- BIO/14
- Type of study-unit
- Obbligatorio (Required)
- Type of learning activities
- Attività formativa monodisciplinare
- Language of instruction
- english
- Contents
- Study of biotech drugs: from production to final formulation, by analysing the safety and efficacy of the product. Knowledge of the biotech drus that are in use in therapy with particular attention at the biosimilar problem.
- Reference texts
- There’s still no available book in italian so far, but some English written books will be suggested during the first lesson. All slides presented during the face-to face lessons will be available to the students with additional scientific literature articles provided at the moment.
- Educational objectives
- This course aims at allowing the student to acquire the knowledge about the rational production of a biotech drug.Specifically:- Aim of the production of a biotech drug- Methodologies in the production of both protein and nucleic acid drugs- Methods in the quality control of a biotech drug; -Antibodies as biotech drugs, -Knowledge of the main biotech drugs in use. Such principles will be analyzed during the exam as well as the ability to design a biotech drug.
- Prerequisites
- Knowledge of principles of general pharmacology
- Teaching methods
- The course is organised as follows:-face-to-face lessons with particular attention to a productive debate between the lecturer and the students about all topics of the course- laboratory practice during which the students can apply some methodologies learned during the course, within the research projects of the lab
- Other information
- face-to-face lessons and lab are optional
- Learning verification modality
- Written exam with multiple choice; possibility to complete with an oral exam
- Extended program
- General principles, RNA drugs, protein and antibodies as drugs; systems of recombinant proteins, methos for the production of biotech drugs, purification and final product formulation, pharmacokinetics of biotech drugs, specific biotech drugs (cytokines, insulin, growth factors, recombinant blood products, monoclonal antibodies) and their therapeutic use, recombinant vaccines, biosimilar drugs.