Unit GENETICS AND EPIGENETICS

Course
Medical, veterinary and forensic biotechnological sciences
Study-unit Code
A001761
Curriculum
In all curricula
Teacher
Enrico Tiacci
Teachers
  • Enrico Tiacci
Hours
  • 57 ore - Enrico Tiacci
CFU
6
Course Regulation
Coorte 2022
Offered
2022/23
Learning activities
Caratterizzante
Area
Discipline biotecnologiche comuni
Academic discipline
BIO/18
Type of study-unit
Obbligatorio (Required)
Type of learning activities
Attività formativa monodisciplinare
Language of instruction
English
Contents
Principles of genetics and epigenetics in general, and in blood diseases in particular
Reference texts
Slides presented and provided by the teacher, and made available in UNISTUDIUM
Educational objectives
The main objective of this course is to provide students with:

- the theoretical basis to acquire the knowledge of the genetic and epigenetic mechanisms underlying human diseases, in particular those of the blood

- the practical basis to leverage the knowledge of such mecahnisms for diagnostic and therapeutic purposes
Prerequisites
A solid knowledge of the following subjects is required:

Genetics
Immunology
Molecular biology
General biology with elements of cytology and histology
Principles of anatomy and general physiology
Biochemistry
Farmacology
Basic bioinformatics and systems biology
Teaching methods
Theoretical and practical lessons

To give continuity to educational activities, during the pandemic caused by COVID-19, we used the UNISTUDIUM platform to carry out online lessons and exams
Other information
None
Learning verification modality
Single, multiple-choice written exam (31 questions; 2-hour duration; no penalization for wrong answers), which may be followed by an oral exam at the discretion of the student if obtaining a vote equal to or greater than 28/30 at the written exam.
Extended program
Genetics and Epigenetics: Introduction

Hematopoiesis

Genetics and epigenetics of myeloid tumors

(Epi-)Genetics of hemoglobinopathies and thalassemias

Genetics-based diagnostic methods for hemoglobinopathies and thalassemias

Genetics and epigenetics of mature lymphoid leukemias and lymphomas

Sanger and next-generation sequencing of nucleic acids.

Digital PCR

Genetic engineering of eukaryotic cells

Gene therapy
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