Unit PHARMACOLOGICAL SCIENCES

ELEMENTS OF CLINICAL PHARMACOLOGY

Code	A001523
CFU	1
Teacher	Alessandro D'arpino
Teachers	Alessandro D'arpino
Hours	12 ore - Alessandro D'arpino
Learning activities	Caratterizzante
Area	Scienze della prevenzione e dei servizi sanitari
Academic discipline	MED/50
Type of study-unit	Obbligatorio (Required)
Educational objectives	Il corso si pone l'obiettivo di fornire agli studenti le basi conoscitive delle esigenze cliniche alla base delle principali preparazioni galeniche e farmaceutiche ivi inclusa la preparazione di antiblastici e le relative implicazioni in termini di sicurezza delle cure. Le conoscenze fornite dal modulo saranno la base per la comprensione dei contenuti del modulo di Metodi e tecniche di farmacologia

PHARMACY TOXICOLOGY

Code	A001521
CFU	1
Teacher	Simona Ronchetti
Teachers	Simona Ronchetti
Hours	12 ore - Simona Ronchetti
Learning activities	Base
Area	Primo soccorso
Academic discipline	BIO/14
Type of study-unit	Obbligatorio (Required)
Language of instruction	italian
Contents	Toxicology: general principles, Drug adverse reactions, antidotes, drug-drug interaction, drug-food interactions, pre-clinical and clinical trials
Reference texts	- F. Rossi, V. Cuomo, C. Riccardi, Farmacologia: principi di base e applicazioni terapeutiche, III Edizione, Edizioni Minerva Medica ¿- Rang, Dale, Ritter, Flower. Farmacologia-C.L. Galli, E. Corsini, M. Marinovich, Tossicologia, Piccin
Educational objectives	The course will allow the student to acquire knowledge about the adverse and toxic effects, as well as the therapeutic bases and the administration route of the most important drugs. The student will be aware of those factors that influence the desired pharmacological and undesired toxicologic effects.
Prerequisites	none requested
Teaching methods	face-to-face lessons
Other information	compulsory course attendance
Learning verification modality	written exam
Extended program	Toxicology: general principles, dose-toxic effect relationship, toxicity curves, organ toxicity drug adverse reactions: classification and examplesantidotes: the most important for poisoning. Drug-drug interaction, drug-food interactions, pre-clinical and clinical trials

GENERAL PHARMACOLOGY

Code	A001520
CFU	2
Teacher	Giada Mondanelli
Teachers	Giada Mondanelli
Hours	24 ore - Giada Mondanelli
Learning activities	Base
Area	Primo soccorso
Academic discipline	BIO/14
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Definitions: drug, desired, unwanted and toxic effects. Pharmacokinetics: description of absorption, distribution, metabolism and elimination of drugs. Pharmacodynamics: definition of pharmacologic receptor, classes of receptors and known mechanisms of signal transduction. Overview of clinical pharmacology.
Reference texts	R. Paoletti, S. Nicosia, F Clementi, G. Fumagalli - Farmacologia generale e molecolare.
Educational objectives	The general pharmacology is the study of the fundamentals of drug action that evaluates the relationship between body and drug, and analyzes the general mechanisms of interaction between the two systems. This course aims to provide the fundamental knowledge of pharmacology, by focusing the attention to the routes of drug administration, the pharmacokinetic processes that the drug undergoes once administered and the mechanisms of action of a drug. The student will achieve the following skills: 1) understanding the concept of drug bioavailability 2) calculating the correct dosage of a drug 2) understanding the mechanism of action of a drug 3) understanding the relevance of the dose-effect concept 4) rational usage of a drug to minimize the toxic effects.
Prerequisites	The student must have knowledge of anatomy, physiology and general pathology. The student must also comply with the required prerequisite.
Teaching methods	Lectures on all the topics of the course.
Other information	The student can reach the teacher at the following email address: giada.mondanelli@unipg.it
Learning verification modality	The exam will be an oral test lasting about 15 minutes. The test is aimed at ascertaining the level of knowledge and understanding get by the student on the the course program. Through the oral test, the teacher will also verify the language skills and student's ability to organize the argument.
Extended program	Definition of drug. Features of the conventional drug. Natural and synthetic drugs. Biodrugs and biotechnological drugs. Primary, side, unwanted and toxic effects. Cellular basis of pharmacokinetics (cell barriers and drug transport across membranes). Absorption and routes of drug administration. Distribution, metabolism and elimination of drugs. Interaction between drugs. Pharmacodynamics: receptors and receptor activation theories. Definition of agonist, antagonist and allosteric modulator. Methods to study the biological responses of a drug, dose-response curves, potency and efficacy of a drug. Binding studies and definition of drug affinity. Classes of receptors (G-protein coupled receptor, ionic receptor, receptor associated with an enzymatic activity, intracellular receptor). Mechanisms of signal transduction

PHARMACOLOGY AND TOXICOLOGY METHODS AND TECHNIQUES

Code	A001522
CFU	1
Teacher	Tiziana Chiocci
Teachers	Tiziana Chiocci
Hours	18 ore - Tiziana Chiocci
Learning activities	Caratterizzante
Area	Scienze e tecniche di laboratorio biomedico
Academic discipline	MED/46
Type of study-unit	Obbligatorio (Required)
Contents	Analisi del ruolo della farmacia ospedaliera, laboratorio galenica sterile (preparati chemioterapici e nutrizione parenterale) e laboratorio galenica non sterile
Reference texts	Slide e altro materiale fornito dal docente
Educational objectives	Conoscenza dei metodi di preparazione galenica e chemioterapica magistrale ed officinale, conoscenza di adeguati comportamenti lavorativi e sicurezza all'interno della farmacia ospedaliera
Prerequisites	Conoscenza del concetto di sterilità e conoscenza dei dispositivi di protezione individuale (DPI)
Teaching methods	Lezioni teoriche ed esercitazioni pratiche in laboratorio di galenica sterile e non sterile
Other information	E-mail del docente: tiziana.chiocci@ospedale.perugia.it a.alunniproietti@ospedale.perugia.it Struttura: galenica clinica
Learning verification modality	Prova orale
Extended program	-Galenica sterile e non sterile, procedure preparatorie, relative norme e strumentazioni -Norme di buona preparazione, DPI -Allestimento farmaci antineoplastici e metodologie di processo -Preparazione sacche nutrizione parenterale e automazione del processo -Percorso formativo del tecnico sanitario di laboratorio biomedico nella farmacia ospedaliera -Acquisizione di principi teorici e di tecniche lavorative in farmacia ospedaliera