Unit PHARMACOLOGY

Course
Medicine and surgery
Study-unit Code
GP004733
Location
TERNI
Curriculum
In all curricula
Teacher
Giuseppe Nocentini
CFU
13
Course Regulation
Coorte 2019
Offered
2022/23
Type of study-unit
Obbligatorio (Required)
Type of learning activities
Attività formativa integrata

PHARMACOLOGY - MOD. 1

Code GP004775
Location TERNI
CFU 3
Teacher Giuseppe Nocentini
Teachers
  • Giuseppe Nocentini
Hours
  • 37.5 ore - Giuseppe Nocentini
Learning activities Caratterizzante
Area Farmacologia, tossicologia e principi di terapia medica
Academic discipline BIO/14
Type of study-unit Obbligatorio (Required)
Language of instruction Italian
Contents Introduction
The development of new drugs and pharmacovigilance
Pharmacokinetics and Clinical Pharmacokinetics
Pharmacodynamics
Toxicology and teratogenicity
Reference texts Reference texts
F. Rossi, V. Cuomo, C. Riccardi. Farmacologia: principi di base e applicazioni terapeutiche, Minerva Medica, terza edizione
B.G. Katzung. Farmacologia Generale e Clinica Piccin, IX edizione or the correspondent XIV American Edition

Consultation texts
Goodman and Gilman’s The pharmacological basis of therapeutics, 12th edition
F. Clementi, G. Fumagalli. Farmacologia generale e molecolare, IV edizione, UTET
S. Govoni. Farmacologia. Casa Editrice Ambrosiana
Educational objectives The ultimate goal of the Course of Pharmacology:
- Knowledge of the pharmacodynamics, pharmacokinetics, adverse side effects, toxicological aspects, the therapeutic foundations and methods of administration of drugs in medical practice
- Be aware of the factors that influence the pharmacological effect and / or therapeutic, as well as the risk / benefit ratio of drug therapy
- Know how to make a reasoned choice of drugs in relation to different pathological situations.
The goal of this Module is master the concepts of General Pharmacology. In particular, the knowledge of the concepts of pharmacodynamics and pharmacokinetics, in order to know the technical terms and understand its meaning when he/she will study the different drugs. Also know the classification of adverse effects and teratogenic effects of drugs. Finally know how you put up a new drug and know the meaning and the needs of pharmacovigilance
Prerequisites Knowledge of Biology, Anatomy and Physiology.
Teaching methods Face-to-face lessons held with the help of projected powerpoint files on 100% of the course topics. At the end of the module a training exercise is carried out. On some key issues, pdf files with relevant publications are provided to the students and discussed in class
Other information The detailed program of the examination and PowerPoint files of the lessons can be downloaded from the website Unistudium
Results of the written exams will be visible on the site: Unistudium.
In the exceptional case in which exams had to be postponed due to force majeure, students booked will be notified personally by e-mail. Also, notice be given also the site: Unistudium
Learning verification modality The course includes 5 modules.The assessment consists of 2 written tests and an oral interview. The first is held upon completion of the program of modules 1 and 2, the second upon completion of the modules 3, 4 and 5. After passing the 2 tests, the student must take a final examination (oral) on topics of clinical pharmacology.
Extended program GENERAL PRINCIPLES
Definition of medication
Origin and classification of drugs
Pharmacological trials, pharmacovigilance

PHARMACOKINETICS
Routes of administration
Absorption, bioavailability
Distribution
Metabolism
Elimination
Main pharmacokinetic parameters: volume of distribution, half-life, clearance
Pharmacokinetics quantitative kinetics of zero order and first order
Clinical pharmacokinetics, kinetics of the drug administered in repeated doses, the concept of steady state PHARMACODYNAMICS
Drug-receptor interaction
Agonists, antagonists, partial agonists and inverse
Dose-response curves and curves quantal
Affinity, potency, efficacy, therapeutic index
Molecular structure of receptors
Mechanisms of signal transduction
Regulation of receptor response
Mechanism of action of drugs and correlation between concentration and pharmacological effect of drugs TOXICOLOGY
Principles of Toxicology
Mechanisms of toxicity
Teratogenic effects of drugs
Abuse, Drug Addiction and
Rational basis of treatment of drug addiction

PHARMACOLOGY - MOD. 2

Code GP004776
Location TERNI
CFU 3
Teacher Giuseppe Nocentini
Teachers
  • Giuseppe Nocentini
  • Simona Ronchetti (Codocenza)
Hours
  • 25 ore - Giuseppe Nocentini
  • 12.5 ore (Codocenza) - Simona Ronchetti
Learning activities Caratterizzante
Area Farmacologia, tossicologia e principi di terapia medica
Academic discipline BIO/14
Type of study-unit Obbligatorio (Required)
Language of instruction Italian
Contents Drugs that act at the level of synapses
Cardiovascular system drugs
Drugs of the sexual function
Drugs acting on blood and blood-forming organs
Clinical Pharmacology
Reference texts Reference texts
F. Rossi, V. Cuomo, C. Riccardi. Farmacologia: principi di base e applicazioni terapeutiche, Minerva Medica, terza edizione
B.G. Katzung. Farmacologia Generale e Clinica Piccin, IX edizione or the correspondent XIV American Edition

Consultation texts
Goodman and Gilman’s The pharmacological basis of therapeutics, 12th edition
F. Clementi, G. Fumagalli. Farmacologia generale e molecolare, IV edizione, UTET
S. Govoni. Farmacologia. Casa Editrice Ambrosiana
Educational objectives The ultimate goal of the Course of Pharmacology:
- Knowledge of the pharmacodynamics, pharmacokinetics, adverse side effects, toxicological aspects, the therapeutic foundations and methods of administration of drugs in medical practice
- Be aware of the factors that influence the pharmacological effect and / or therapeutic, as well as the risk / benefit ratio of drug therapy
- Know how to make a reasoned choice of drugs in relation to different pathological situations.
The goal of this Module is to know for each class: the name of the main drugs, their mechanism of action, their indications, adverse effects
Prerequisites Knowledge of Biology, Anatomy and Physiology.
Teaching methods Face-to-face lessons held with the help of projected powerpoint files on 100% of the course topics. At the end of the module a training exercise is carried out. On some key issues, pdf files with relevant publications are provided to the students and discussed in class
Other information The detailed program of the examination and PowerPoint files of the lessons can be downloaded from the website Unistudium
Results of the written exams will be visible on the site: Unistudium.
In the exceptional case in which exams had to be postponed due to force majeure, students booked will be notified personally by e-mail. Also, notice be given also the site: Unistudium
Learning verification modality The course includes 5 modules.The assessment consists of 2 written tests and an oral interview. The first is held upon completion of the program of modules 1 and 2, the second upon completion of the modules 3, 4 and 5. After passing the 2 tests, the student must take a final examination (oral) on topics of clinical pharmacology.
Extended program DRUGS ACTING AT THE JUNCTION OF SYNAPSES
Neurohumoral transmission: the autonomic and somatic motor
Cholinergic Agonists
Anticholinesterases
Muscarinic antagonists
Drugs acting on the neuromuscular junction and autonomic ganglia
Catecholamines and sympathomimetic drugs
Adrenergic neuron antagonist

CARDIOVASCULAR SYSTEM DRUGS
Drugs that affect renal function and electrolyte metabolism
Pharmacological control of the renin-angiotensin-aldosterone
Antihypertensive drugs
Antianginal drugs
Cardiac glycosides
Antiarrhythmic drugs
Drugs for treatment of dyslipidemia

DRUGS OF THE SEXUAL FUNCTION

DRUGS ACTING ON THE BLOOD
Hematopoietic agents: growth factors and vitamins
Anticoagulants, thrombolytics, and antiplatelet

PRINCIPLES OF CLINICAL PHARMACOLOGY AND THERAPY
Variability in individual response to drugs: pharmacokinetic and pharmacodynamic variables, tolerance
Pharmacogenetics
Drug interactions

PHARMACOLOGY - MOD. 3

Code GP004777
Location TERNI
CFU 3
Teacher Stefano Bruscoli
Teachers
  • Stefano Bruscoli
Hours
  • 37.5 ore - Stefano Bruscoli
Learning activities Caratterizzante
Area Formazione clinica interdisciplinare e medicina basata sulle evidenze
Academic discipline BIO/14
Type of study-unit Obbligatorio (Required)
Language of instruction Italian
Contents Drugs acting on the Central Nervous System
Anti-inflammatory drugs and painkillers
Reference texts F. Rossi, V. Cuomo, C. Riccardi. Farmacologia: principi di base e applicazioni terapeutiche, Minerva Medica, terza edizione

Reference books
Goodman and Gilman’s The pharmacological basis of therapeutics, 12th edition
F. Clementi, G. Fumagalli. Farmacologia generale e molecolare, IV edizione, UTET
Educational objectives The ultimate goal of the Course of Pharmacology: - Knowledge of the pharmacodynamics, pharmacokinetics, adverse side effects, toxicological aspects, the therapeutic foundations and methods of administration of drugs in medical practice - Be aware of the factors that influence the pharmacological effect and / or therapeutic, as well as the risk / benefit ratio of drug therapy - Know how to make a reasoned choice of drugs in relation to different pathological situations.
The goal of this Module is to know for each class: the name of the main drugs, their mechanism of action, their indications, adverse effects
Prerequisites Knowledge of Biology, Anatomy and Physiology.
Teaching methods Face-to-face lessons held with the help of projected powerpoint files on 100% of the course topics. At the end of the module a training exercise is carried out. On some key issues, pdf files with relevant publications are provided to the students and discussed in class
Other information The detailed program of the examination and PowerPoint files of the lessons can be downloaded from the website Unistudium
Results of the written exams will be visible on the site: Unistudium.
In the exceptional case in which exams had to be postponed due to force majeure, students booked will be notified personally by e-mail. Also, notice be given also the site: Unistudium
Learning verification modality The course includes 5 modules.The assessment consists of 2 written tests and an oral interview. The first is held upon completion of the program of modules 1 and 2, the second upon completion of the modules 3, 4 and 5. After passing the 2 tests, the student must take a final examination (oral) on topics of clinical pharmacology.
Extended program DRUGS ACTING ON THE CENTRAL NERVOUS SYSTEM
Neurotransmission and the central nervous system
Anxiolytics and sedative-hypnotics
Anticonvulsants
Antipsychotic drugs
Antidepressants and mood stabilizers
Drugs for treatment of neurodegenerative diseases
Drugs for the treatment of migraine
Medications to control vomiting

AUTACOIDS, ANTI-INFLAMMATORY DRUGS AND PAINKILLERS
General information on inflammation and mediators involved
Histamine and antihistamines
Non-steroidal anti-inflammatory drugs, drugs used in the treatment of rheumatoid arthritis and gout
Steroidal anti-inflammatory drugs
Opioid analgesics and their antagonists
Local anesthetics

PHARMACOLOGY - MOD. 4

Code GP004778
Location TERNI
CFU 3
Teacher Giuseppe Nocentini
Teachers
  • Giuseppe Nocentini
Hours
  • 37.5 ore - Giuseppe Nocentini
Learning activities Affine/integrativa
Area Attività formative affini o integrative
Academic discipline BIO/14
Type of study-unit Obbligatorio (Required)
Language of instruction Italian
Contents Pharmacology of the immune system
Pharmacology of asthma
Anti-istaminic drugs
Pharmacology of gastro-enteric tract
Anti-infective chemotherapy
Reference texts F. Rossi, V. Cuomo, C. Riccardi. Farmacologia: principi di base e applicazioni terapeutiche, Minerva Medica, terza edizione

Reference books
Goodman and Gilman’s The pharmacological basis of therapeutics, 12th edition
F. Clementi, G. Fumagalli. Farmacologia generale e molecolare, IV edizione, UTET
Educational objectives The ultimate goal of the Course of Pharmacology:
- Knowledge of the pharmacodynamics, pharmacokinetics, adverse side effects, toxicological aspects, the therapeutic foundations and methods of administration of drugs in medical practice
- Be aware of the factors that influence the pharmacological effect and / or therapeutic, as well as the risk / benefit ratio of drug therapy
- Know how to make a reasoned choice of drugs in relation to different pathological situations.
The goal of this Module is to know for each class: the name of the main drugs, their mechanism of action, their indications, adverse effects
Prerequisites Knowledge of Biology, Anatomy and Physiology.
Teaching methods Face-to-face lessons held with the help of projected powerpoint files on 100% of the course topics. At the end of the module a training exercise is carried out. On some key issues, pdf files with relevant publications are provided to the students and discussed in class
Other information The detailed program of the examination and PowerPoint files of the lessons can be downloaded from the website Unistudium
Results of the written exams will be visible on the site: Unistudium.
In the exceptional case in which exams had to be postponed due to force majeure, students booked will be notified personally by e-mail. Also, notice be given also the site: Unistudium
Learning verification modality The course includes 5 modules.The assessment consists of 2 written tests and an oral interview. The first is held upon completion of the program of modules 1 and 2, the second upon completion of the modules 3, 4 and 5. After passing the 2 tests, the student must take a final examination (oral) on topics of clinical pharmacology.
Extended program PHARMACOLOGY OF THE IMMUNE SYSTEM
Serums and Vaccines
Immunosuppressants, immunomodulators and immunostimulantsDRUGS USED IN TREATMENT OF ASTHMAANTIISTAMINIC DRUGSDRUGS AFFECTING GASTROINTESTINAL FUNCTION
Antiulcer drugs
Drugs antiesofagite
Drugs that affect gastrointestinal motilityANTIMICROBIAL CHEMOTHERAPYANTI-BACTERIC CHEMOTHERAPY
General considerations
- MIC
- Susceptibility
- Distribution of the drug in the inflamed site
- Mechanisms of resistance
- Classification of antibiotics
- Dosages and dosing intervals for different types of antibiotics
- Antibiotics with time-dependent activity
- Antibiotics with concentration-dependent activity
- Bacteriostatic and bactericidal antibiotics
- Broad-spectrum drugs
- surgical and nonsurgical antimicrobial prophylaxis
Mechanism of action, the main compounds, the main indications, the major side effects and the likelihood of resistance:
- Beta-lactams (including classification of beta-lactams and strategy to prevent the inactivation of these drugs)
- Protein synthesis inhibitors
- tetracycline
- aminoglycosides
- macrolides
- Sulfonamides and cotrimoxazole
- quinolonesANTIVIRAL CHEMOTHERAPYViruses and strategies with which they can be controlled
The most important pharmacokinetic properties, clinical uses and adverse effects of:
- Acyclovir and other drugs against herpes virus
- Zanamivir and other antiinfluenzali
- anti-HCV
- Notes on the anti-CMV
- Antiretrovirals
- - AZT and other NRTIs
- - NNRTI
- - Protease inhibitors
ANTIPROTOZOAL CHEMOTHERAPY
ANTIFUNGAL CHEMOTHERAPY

PHARMACOLOGY - MOD. 5

Code GP004779
Location TERNI
CFU 1
Teacher Giuseppe Nocentini
Teachers
  • Giuseppe Nocentini
Hours
  • 12.5 ore - Giuseppe Nocentini
Learning activities Affine/integrativa
Area Attività formative affini o integrative
Academic discipline BIO/14
Type of study-unit Obbligatorio (Required)
Language of instruction Italian
Contents Cancer Chemotherapy
Drugs affecting uterine motility
General Anesthetics
Vitamins
Endocrine system drugs
Reference texts Reference texts
F. Rossi, V. Cuomo, C. Riccardi. Farmacologia: principi di base e applicazioni terapeutiche, Minerva Medica, terza edizione
B.G. Katzung. Farmacologia Generale e Clinica Piccin, IX edizione or the correspondent XIV American Edition

Consultation texts
Goodman and Gilman’s The pharmacological basis of therapeutics, 12th edition
F. Clementi, G. Fumagalli. Farmacologia generale e molecolare, IV edizione, UTET
S. Govoni. Farmacologia. Casa Editrice Ambrosiana
Educational objectives The ultimate goal of the Course of Pharmacology:
- Knowledge of the pharmacodynamics, pharmacokinetics, adverse side effects, toxicological aspects, the therapeutic foundations and methods of administration of drugs in medical practice
- to be aware of the factors that influence the pharmacological effect and / or therapeutic, as well as the risk / benefit ratio of drug therapy
- to know how to make a reasoned choice of drugs in relation to different pathological situations.
The goal of this Module is to know for each class: the name of the main drugs, their mechanism of action, their indications, adverse effects
Prerequisites Knowledge of Biology, Anatomy and Physiology.
Teaching methods Face-to-face lessons held with the help of projected powerpoint files on 100% of the course topics. At the end of the module a training exercise is carried out. On some key issues, pdf files with relevant publications are provided to the students and discussed in class
Other information The detailed program of the examination and PowerPoint files of the lessons can be downloaded from the website Unistudium
Results of the written exams will be visible on the site: Unistudium.
In the exceptional case in which exams had to be postponed due to force majeure, students booked will be notified personally by e-mail. Also, notice be given also the site: Unistudium
Learning verification modality The course includes 5 modules.The assessment consists of 2 written tests and an oral interview. The first is held upon completion of the program of modules 1 and 2, the second upon completion of the modules 3, 4 and 5. After passing the 2 tests, the student must take a final examination (oral) on topics of clinical pharmacology.
Extended program CANCER CHEMOTHERAPY The tumors and the various treatment approaches
The problem of an exact diagnosis: the microarray
- Main features of different microarray commercially
- Microarray cancer:
- In breast cancer
- In hematological malignancies
The new cancer treatments
- angiogenesis inhibitors
- Monoclonal antibodies (humanized antibodies) against membrane receptors with pro-proliferative
- immunotoxins
- Inhibitors of tyrosine kinase
The conventional cancer treatments (some common properties, the most common adverse effects, cycle specific and nonspecific drugs)
The main oler generation anti-tumor drugs (mechanism of action, clinical uses and adverse effects peculiar) of:
- alkylating
- antimetabolites
- methotrexate
- Purine and pyrimidine analogs
- Inhibitors of ribonucleotide reductase
- antibiotics
- anthracycline
- bleomycin
- Inhibitors of the mitotic spindle
- Hormones and anti-hormones
DRUGS AFFECTING UTERINE MOTILITY

GENERAL ANESTHETICS

VITAMINS

DRUGS OF THE ENDOCRINE SYSTEM
Pituitary Hormones and Related Substances
Thyroid and Antithyroid
Estrogens, progestins, birth control
Androgens and anabolic steroids
Insulin and oral hypoglycemicanti-osteoporotic drugs
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