Unit INTERGRATED SCIENCES OF HUMAN FUNCTIONS

BIOCHEMISTRY

Code	GP003873
CFU	2
Teachers	Tommaso Beccari (Codocenza)
Hours	20 ore (Codocenza) - Tommaso Beccari
Learning activities	Base
Area	Scienze biomediche
Academic discipline	BIO/10
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Principle of basic Biochemistry
Reference texts	Biochimica e Biologia per le professioni sanitarie. McGraw Hill Education
Educational objectives	Understanding the biochemical mechanism of the cell and the necessary medotology
Prerequisites	Inorganic and organic chemistry
Teaching methods	Frontal lessons
Other information	None
Learning verification modality	Written exam
Extended program	Water and biological buffers - amino acids, peptides and proteins - tridimensinal strucure of proteins- protein functions - enzyme and enzyme catalysis - carbohydrates and glycobiology - monosaccharides- disaccharides and polysaccharides - nucleic acid - lipids- storage lipis - structural lipids- biological membranes - membrane transport - biosignaling - bioenergetics and metabolism- glycolisis and gluconeogensis - Krebs cycle - catabolism of fatty acids - aminoacids oxidation and urea cycle - oxidative phosphorilation - biosynthesis of carbohydrates - biosynthesis of aminoacids - hormonal regulation - protein metabolism -

APPLIED BIOLOGY

Code	GP003871
CFU	2
Teacher	Cinzia Antognelli
Teachers	Cinzia Antognelli
Hours	20 ore - Cinzia Antognelli
Learning activities	Base
Area	Scienze biomediche
Academic discipline	BIO/13
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Prokaryotic and eukaryotic cells. Flow of genetic information within a biological system and its regulation. Cell cycle and its control. Mutations: types and causes. Reproduction of multicellular living organisms: meiosis and gametogenesis.
Reference texts	R. Roberti, G. Alunni Bistocchi, C. Antognelli, VN Talesa - Biochimica e Biologia per le professioni sanitarie - McGrawHillP. Bonaldo, S. Suga, R. Pierantoni, P. Riva, M.G, Romanelli- Biologia e Genetica - EdiSES
Educational objectives	The aim of the course is the integrated study of the cell and living organisms, with emphasis on the mechanisms involved in: organelles biogenesis and cellular structures, cell-cell interactions, cell-extracellular matrix interactions, DNA duplication, transmission of the genetic information, gene expression, cell proliferation. The ability to learn, relate and integrate one concept to another will be considered fundamental issues in order to facilitate the understanding of the disciplines provided in the subsequent years of the Degree Course.
Prerequisites	Basic elements of chemistry
Teaching methods	Face-to-face
Other information	Site of the teacher: Nuova sede dei Dipartimenti di Medicina, Edificio B, 4° piano, P.le L Severi 1, Sant'Andrea delle Fratte, Perugia
Learning verification modality	Written examination
Extended program	The characteristics of living organisms. Biological macromolecules: proteins, lipids and glucids (general characteristics). Models of cellular organization: prokaryotes and eukaryotes. Viruses: general characteristics. Animal eukaryotic cell. Plasma membrane: structure and functions. The main mechanisms of membrane transport and cellular communication; cytoplasm; ribosomes; rough and smooth endoplasmic reticulum; Golgi apparatus; lysosomes; peroxisomes; mitochondria and the energy problem; cytoskeleton (general characteristics), nucleus and nucleolus. DNA and RNA: structure and function. Organization of chromatin, chromosomes. The eukaryotic gene. Gene expression: transcription, maturation of primary transcripts, genetic code, translation. Regulation of gene expression: general characteristics. Cell cycle: interphase, DNA replication, mitosis. Cell cycle control: check-point and CdK-cyclines. Proto-oncogenes, oncogenes and tumor suppressor. Gene mutations (point mutations, missense, nonsense, neutral mutations), genomic mutations (aneuploidy and polyploidy mutations) and chromosomal mutations (deletion, duplication, inversion, translocation). Human normal and pathological karyotype. Heterochromatinization of the X chromosome. Reproduction of multicellular organisms; meiosis and its biological meaning, gametogenesis (spermatogenesis and oogenesis).

MEDICAL GENETICS

Code	GP003872
CFU	2
Teacher	Emilio Donti
Teachers	Emilio Donti
Hours	20 ore - Emilio Donti
Learning activities	Base
Area	Scienze biomediche
Academic discipline	MED/03
Type of study-unit	Obbligatorio (Required)