Unit SYSTEMIC PATHOLOGY V
- Course
- Medicine and surgery
- Study-unit Code
- GP004561
- Curriculum
- In all curricula
- CFU
- 12
- Course Regulation
- Coorte 2021
- Offered
- 2024/25
- Type of study-unit
- Obbligatorio (Required)
- Type of learning activities
- Attività formativa integrata
BLOOD DISEASES - MOD. 1
| Code | GP004621 |
|---|---|
| CFU | 2 |
| Learning activities | Caratterizzante |
| Area | Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica |
| Academic discipline | MED/15 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 2
- Teacher
- Maria Paola Martelli
- Teachers
- Maria Paola Martelli
- Vincenzo Maria Perriello
- Hours
- 25 ore - Maria Paola Martelli
- 4 ore - Vincenzo Maria Perriello
Cognomi M-Z
- CFU
- 2
- Teacher
- Maria Paola Martelli
- Teachers
- Maria Paola Martelli
- Vincenzo Maria Perriello
- Hours
- 25 ore - Maria Paola Martelli
- 4 ore - Vincenzo Maria Perriello
BLOOD DISEASES - MOD. 2
| Code | GP004622 |
|---|---|
| CFU | 1 |
| Learning activities | Caratterizzante |
| Area | Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica |
| Academic discipline | MED/15 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 1
- Teacher
- Antonio Pierini
- Teachers
- Antonio Pierini
- Hours
- 12.5 ore - Antonio Pierini
Cognomi M-Z
- CFU
- 1
- Teacher
- Antonio Pierini
- Teachers
- Antonio Pierini
- Hours
- 12.5 ore - Antonio Pierini
DISEASES OF THE IMMUNE SYSTEM
| Code | GP005656 |
|---|---|
| CFU | 2 |
| Learning activities | Caratterizzante |
| Area | Medicina delle attività motorie e del benessere |
| Academic discipline | MED/09 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 2
- Teacher
- Antonio Pierini
- Teachers
- Antonio Pierini
- Hours
- 25 ore - Antonio Pierini
Cognomi M-Z
- CFU
- 2
- Teacher
- Antonio Pierini
- Teachers
- Antonio Pierini
- Hours
- 25 ore - Antonio Pierini
MOLECULAR MEDICINE
| Code | GP004623 |
|---|---|
| CFU | 1 |
| Learning activities | Caratterizzante |
| Area | Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica |
| Academic discipline | MED/15 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 1
- Teacher
- Roberta La Starza
- Teachers
- Roberta La Starza
- Hours
- 12.5 ore - Roberta La Starza
- Language of instruction
- Italian
- Contents
- Technological approaches for genome study: cytogenetics, molecular cytogenetics, microarrays, NGS, WET assay. Leukemic and cancer stem cells, multistep process of oncogenesis; mechanisms of deregulation of oncogenes, oncosuppressors, repair genes and check-point genes. Basic principles of epigenetic regulation in DNA transcription and gene expression
Hematopietic clonality, clonal hematopoiesis and human diseases, and pathogenesis of leukemias. Pathogenesis models of congenital and acquired bone marrow failures. Patterns of pathogenesis of acute leukemias. Function of tyrosine kinases. Models of pathogenesis of lymphoproliferative disorders. Models of pathogenesis of myeloma. Patterns of pathogenesis of solid tumors (central nervous system). - Reference texts
- The material will be provided by professor.
- Educational objectives
- Learning study approaches for genetic and epigenetic characterization of blood diseases. Fundamental basis for understanding the processes of oncogenesis of major hematologic cancers.
- Prerequisites
- Basic concepts of molecular biology.
- Teaching methods
- Frontal lessons;
Seminars. - Other information
- None.
- Learning verification modality
- Multiple choice quiz or oral exam.
- Extended program
- Technological approaches for genome study: conventional cytogenetics, fluorescence in situ hybridization (interphase, metaphase, on tissue), multi-FISH, arrays on DNA and RNA, NGS targets.
Characteristics of leukemic and cancer stem cell
Study of the multistep process of oncogenesis, mechanisms of alteration of oncogenes, oncosuppressors, repair genes and check-point genes.
Intratumoral heterogeneity, clonality, and subclonality of genomic alterations.
Oncogenes and oncosuppressors: role and type of deregulation.
Principles of epigenetic regulation, both at the transcriptional and post-transcriptional levels.
Patterns of pathogenesis of congenital and acquired bone marrow failure.
Patterns of pathogenesis of Acute and chronic Leukemias. Function and involvement of tyrosine kinases in human neoplasms.
Pathogenesis models of Multiple Myeloma and Lymphomas.
Patterns of pathogenesis of solid tumors (central nervous system). - Obiettivi Agenda 2030 per lo sviluppo sostenibile
- 3 - Health
Cognomi M-Z
- CFU
- 1
- Teacher
- Roberta La Starza
- Teachers
- Roberta La Starza
- Hours
- 12.5 ore - Roberta La Starza
- Language of instruction
- Italian
- Contents
- Technological approaches for genome study: cytogenetics, molecular cytogenetics, microarrays, NGS, WET assay. Leukemic and cancer stem cells, multistep process of oncogenesis; mechanisms of deregulation of oncogenes, oncosuppressors, repair genes and check-point genes. Basic principles of epigenetic regulation in DNA transcription and gene expression
Hematopietic clonality, clonal hematopoiesis and human diseases, and pathogenesis of leukemias. Pathogenesis models of congenital and acquired bone marrow failures. Patterns of pathogenesis of acute leukemias. Function of tyrosine kinases. Models of pathogenesis of lymphoproliferative disorders. Models of pathogenesis of myeloma. Patterns of pathogenesis of solid tumors (central nervous system). - Reference texts
- The material will be provided by professor.
- Educational objectives
- Learning study approaches for genetic and epigenetic characterization of blood diseases. Fundamental basis for understanding the processes of oncogenesis of major hematologic cancers.
- Prerequisites
- Basic concepts of molecular biology.
- Teaching methods
- Frontal lessons;
Seminars. - Other information
- None.
- Learning verification modality
- Multiple choice quiz or oral exam.
- Extended program
- Technological approaches for genome study: conventional cytogenetics, fluorescence in situ hybridization (interphase, metaphase, on tissue), multi-FISH, arrays on DNA and RNA, NGS targets.
Characteristics of leukemic and cancer stem cell
Study of the multistep process of oncogenesis, mechanisms of alteration of oncogenes, oncosuppressors, repair genes and check-point genes.
Intratumoral heterogeneity, clonality, and subclonality of genomic alterations.
Oncogenes and oncosuppressors: role and type of deregulation.
Principles of epigenetic regulation, both at the transcriptional and post-transcriptional levels.
Patterns of pathogenesis of congenital and acquired bone marrow failure.
Patterns of pathogenesis of Acute and chronic Leukemias. Function and involvement of tyrosine kinases in human neoplasms.
Pathogenesis models of Multiple Myeloma and Lymphomas.
Patterns of pathogenesis of solid tumors (central nervous system). - Obiettivi Agenda 2030 per lo sviluppo sostenibile
- 3 - Health
REUMATHOLOGY
| Code | GP005657 |
|---|---|
| CFU | 2 |
| Learning activities | Caratterizzante |
| Area | Clinica delle specialità medico-chirurgiche |
| Academic discipline | MED/16 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 2
- Teacher
- Roberto Gerli
- Teachers
- Giacomo Cafaro (Codocenza)
- Roberto Gerli
- Hours
- 5 ore (Codocenza) - Giacomo Cafaro
- 20 ore - Roberto Gerli
Cognomi M-Z
- CFU
- 2
- Teacher
- Elena Bartoloni Bocci
- Teachers
- Elena Bartoloni Bocci
- Hours
- 25 ore - Elena Bartoloni Bocci
PROFESSIONALISING TRAINING IN BLOOD DISEASES
| Code | GP004624 |
|---|---|
| CFU | 1 |
| Learning activities | Altro |
| Area | Tirocini formativi e di orientamento |
| Academic discipline | MED/15 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 1
- Teacher
- Duccio Martelli
- Teachers
- Maria Paola Martelli (Codocenza)
- Hours
- 25 ore (Codocenza) - Maria Paola Martelli
Cognomi M-Z
- CFU
- 1
- Teacher
- Maria Paola Martelli
- Teachers
- Maria Paola Martelli
- Hours
- 25 ore - Maria Paola Martelli
PROFESSIONALISING TRAINING IN DISEASES OF THE IMMUNE SYSTEM
| Code | GP005658 |
|---|---|
| CFU | 1 |
| Learning activities | Altro |
| Area | Tirocini formativi e di orientamento |
| Academic discipline | MED/09 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 1
- Teacher
- Andrea Pierini
- Teachers
- Antonio Pierini (Codocenza)
- Hours
- 25 ore (Codocenza) - Antonio Pierini
Cognomi M-Z
- CFU
- 1
- Teacher
- Antonio Pierini
- Teachers
- Antonio Pierini
- Hours
- 25 ore - Antonio Pierini
PROFESSIONALISING TRAINING IN MOLECULAR MEDICINE
| Code | GP004625 |
|---|---|
| CFU | 1 |
| Learning activities | Altro |
| Area | Tirocini formativi e di orientamento |
| Academic discipline | MED/15 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 1
- Teacher
- Roberta La Starza
- Teachers
- Roberta La Starza
- Hours
- 25 ore - Roberta La Starza
- Language of instruction
- Italian
- Contents
- Introduction to technologies used to study the genome, DNA methylation, and histone methylation. Protocols and their applications. Diagnostic algorithms aimed at classification of human malignancies and identification of diagnostic and predictive markers.
- Reference texts
- None.
- Educational objectives
- Ability to address diagnostic investigations and optimize procedures.
- Prerequisites
- Knowledge of the genetic basis of tumors.
- Teaching methods
- Tutor system in working groups.
- Other information
- None.
- Learning verification modality
- During the exam.
- Extended program
- Conventional cytogenetics. FISH, SNPa, RNA microarray, PCR, sequencing, sanger sequencing and NGS. Telomeres, Chromosomal instability test. Test on paraffin sections. Nucleic acids, separation. Microarrays.
- Obiettivi Agenda 2030 per lo sviluppo sostenibile
- 3 - Health
Cognomi M-Z
- CFU
- 1
- Teacher
- Roberta La Starza
- Teachers
- Roberta La Starza
- Hours
- 25 ore - Roberta La Starza
- Language of instruction
- Italian
- Contents
- Introduction to technologies used to study the genome, DNA methylation, and histone methylation. Protocols and their applications. Diagnostic algorithms aimed at classification of human malignancies and identification of diagnostic and predictive markers.
- Reference texts
- None.
- Educational objectives
- Ability to address diagnostic investigations and optimize procedures.
- Prerequisites
- Knowledge of the genetic basis of tumors.
- Teaching methods
- Tutor system in working groups.
- Other information
- None.
- Learning verification modality
- During the exam.
- Extended program
- Conventional cytogenetics. FISH, SNPa, RNA microarray, PCR, sequencing, sanger sequencing and NGS. Telomeres, Chromosomal instability test. Test on paraffin sections. Nucleic acids, separation. Microarrays.
- Obiettivi Agenda 2030 per lo sviluppo sostenibile
- 3 - Health
PROFESSIONALISING TRAINING IN REUMATHOLOGY
| Code | GP005659 |
|---|---|
| CFU | 1 |
| Learning activities | Altro |
| Area | Tirocini formativi e di orientamento |
| Academic discipline | MED/16 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 1
- Teacher
- Roberto Gerli
- Teachers
- Roberto Gerli
- Hours
- 25 ore - Roberto Gerli
Cognomi M-Z
- CFU
- 1
- Teacher
- Elena Bartoloni Bocci
- Teachers
- Elena Bartoloni Bocci
- Hours
- 25 ore - Elena Bartoloni Bocci