Unit NEUROBIOLOGY
- Course
- Biology
- Study-unit Code
- A003085
- Curriculum
- Biosanitario
- Teacher
- Fabio Franciolini
- Teachers
-
- Fabio Franciolini
- Hours
- 47 ore - Fabio Franciolini
- CFU
- 6
- Course Regulation
- Coorte 2024
- Offered
- 2024/25
- Learning activities
- Caratterizzante
- Area
- Discipline del settore biomedico
- Academic discipline
- BIO/09
- Type of study-unit
- Obbligatorio (Required)
- Type of learning activities
- Attività formativa monodisciplinare
- Language of instruction
- English
- Contents
- NEUROBIOLOGY course investigatesthe the biological basis of memory
- Reference texts
- No reference textbook is adopted. Instead, we have constructed over the years a detailed set of slides (>150) that contains essentially all the information the student needs to know for an excellent exam paper.
The above slides are also useful outline for further insights that the student wants to develop on the various topics. - Educational objectives
- Understanding the biological basis of memory
- Prerequisites
- In order to understand the course content, the student must possess the following knowledge:1) Principles of Chemistry, Physics, Anatomy and Biochemistry. 2) Principles of General Physiology. 3) Knowledge of the structure of membrane proteins, with special reference to ion channels.
- Teaching methods
- Teaching activities will be carried out through class lectures.
- Other information
- ------------- ------------
- Learning verification modality
- Oral Examination.
For information on support services for students with disabilities and/or DSA, visit http://www.unipg.it/disabilita-e-dsa - Extended program
- Types, stages and processes of memory
Types of memory: explicit memory and implicit memory. Implicit memory: classical conditioning. Stages of memory: sensory, short-term, long-term. Memory processes: encoding, storage, retrival. Localization of memory: studies of brain lesions. Gall and the phrenological doctrine. Broca and the broca area-Wernicke and Wernicke's area. Lashley and diffuse memory. Milner and the H.M. patient.
Aplysia as a model for the study of implicit memory
Kandel and his scientific path to the Nobel Prize. Reductionist approach in the study of memory. Aplysia and the gill retraction reflex. Habit. Short-term and long-term sensitization. General structure of the nervous system in Aplysia. Neural circuits in the gill retraction reflex. Mechanism and transduction of long-term sensitization. Long-term memory and protein synthesis. Long-term memory and development of new synaptic buttons. In vitro sensitization experiments and role of serotonin.
The mouse as a model for the study of explicit memory.
Explicit memory and the hippocampus. Anatomy of the hippocampus: Shaffer's collateral and CA1 pyramidal neurons. Long-term potentiation (LTP): early and late phase. Mechanism of the early phase of LTP. Role of glutamate receptors. AMPA and NMDA receptors. Behavioral testing in mice: conditioning protocols. 'Place cells' in hippocampus and their properties. 'Place cells' and experiments with R(AB) transgenic mice. - Obiettivi Agenda 2030 per lo sviluppo sostenibile