Unit PHARMACOLOGICAL SCIENCES

ELEMENTS OF CLINICAL PHARMACOLOGY

Code	A001523
CFU	1
Teacher	Sara Pugliese
Teachers	Alessandro D'arpino (Codocenza) Sara Pugliese
Hours	6 ore (Codocenza) - Alessandro D'arpino 6 ore - Sara Pugliese
Learning activities	Caratterizzante
Area	Scienze della prevenzione e dei servizi sanitari
Academic discipline	MED/50
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Elements of pharmacology, technique and pharmaceutical legislation applied operationally in a Hospital Pharmacy lab of Clinical Galenica
Reference texts	Slides projected in class
Educational objectives	The course aims to provide students with the knowledge bases of the clinical needs underlying the main galenic and pharmaceutical preparations including the preparation of antiblastics and the related implications in terms of treatment safety. The knowledge provided by the module will be the basis for understanding the contents of the Pharmacology Methods and Techniques module
Prerequisites	“General chemistry and chemistry laboratory” (1st year, 1st semester) is preparatory
Teaching methods	Frontal lessons
Other information	Teachers are available to receive students upon request via email
Learning verification modality	Learning is verified through an oral test carried out at the same time as the other modules of the same course.
Extended program	Oncological galenics: the tumor, main classes of oncological drugs and routes of administration, definitions, regulatory references/scientific society documents/guidelines, personal, rooms/environments, preparation procedures and methods, sterility, exposure of personnel and collective/individual protective equipment. Neonatal parenteral nutrition. Oral pharmaceutical forms (capsules, suspensions) Eye drops

PHARMACY TOXICOLOGY

Code	A001521
CFU	1
Teacher	Simona Ronchetti
Teachers	Simona Ronchetti
Hours	12 ore - Simona Ronchetti
Learning activities	Base
Area	Primo soccorso
Academic discipline	BIO/14
Type of study-unit	Obbligatorio (Required)
Language of instruction	italian
Contents	Toxicology: general principles, Drug adverse reactions, antidotes, drug-drug interaction, drug-food interactions, pre-clinical and clinical trials
Reference texts	- F. Rossi, V. Cuomo, C. Riccardi, Farmacologia: principi di base e applicazioni terapeutiche, III Edizione, Edizioni Minerva Medica ¿- Rang, Dale, Ritter, Flower. Farmacologia-C.L. Galli, E. Corsini, M. Marinovich, Tossicologia, Piccin There are planned pathways, materials, and/or assessment methodologies consistent with the needs of disabled and/or DSA students
Educational objectives	The course will allow the student to acquire knowledge about the adverse and toxic effects, as well as the therapeutic bases and the administration route of the most important drugs. The student will be aware of those factors that influence the desired pharmacological and undesired toxicologic effects. It takes into account also the handling of those drugs that are potentially harmful for the technician.
Prerequisites	basic principle of general chemistry
Teaching methods	The lessons are frontal, with direct interaction and occasionally discussions on the topic, with examples drawn from the practical activity of a laboratory technician. There are planned pathways, materials, and/or assessment methodologies consistent with the needs of disabled and/or DSA students
Other information	Compulsory course attendance. Office hours: fridays 12-13
Learning verification modality	oral exam, with 2 questions to be answered in 7-8 minutes There are planned pathways, materials, and/or assessment methodologies consistent with the needs of disabled and/or DSA students. Please visit the web site on http://www.unipg.it/disabilita-e-dsa
Extended program	Toxicology: general principles, dose-toxic effect relationship, toxicity curves, organ toxicity drug adverse reactions: classification and examplesantidotes: the most important for poisoning. Drug-drug interaction, drug-food interactions, pre-clinical and clinical trials
Obiettivi Agenda 2030 per lo sviluppo sostenibile	Health and wellness

GENERAL PHARMACOLOGY

Code	A001520
CFU	2
Teacher	Maria Teresa Pallotta
Teachers	Maria Teresa Pallotta
Hours	24 ore - Maria Teresa Pallotta
Learning activities	Base
Area	Primo soccorso
Academic discipline	BIO/14
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	General principles of Pharmacology. Pharmacodynamics: drug receptors and receptors/mechanisms. Pharmacokinetics: disposition and metabolisms of drugs. Drug development, evaluation of new drugs and principles of therapeutics. Pharmacology for special patient populations.
Reference texts	R. Paoletti, S. Nicosia, F Clementi, G. Fumagalli - Farmacologia generale e molecolare. Moreover, the presentations used during the class are available to the student and can be downloaded from Unistudium.
Educational objectives	The general pharmacology is the study of the fundamentals of drug action that evaluates the relationship between body and drug, and analyzes the general mechanisms of interaction between the two systems. All the drugs share some general principles that are independent of the nature of the effect and which are common to all. The main knowledge gained will be related to: 1) absorption, distribution, metabolism and elimination of drugs 2) routes of administration of the drugs 3) bioavailability and bioequivalence 4) Receptors and theories of receptor activation 5) mechanisms of drug action and signal transduction pathways. The knowledge gained will enable the student to achieve the following skills: 1) be able to calculate the correct dosage of a drug 2) avoid toxic effects 3) rational use of medicines and achieve maximum efficacy with minimal toxicity
Prerequisites	The student must have knowledge of anatomy, physiology and general pathology. The student must also comply with the required prerequisite.
Teaching methods	Lectures on all the topics of the course.
Learning verification modality	The exam will be an oral test lasting about 15 minutes. The test is aimed at ascertaining the level of knowledge and understanding get by the student on the the course program. Through the oral test, the teacher will also verify the language skills and student's ability to organize the argument.
Extended program	Definition of drug. Features of the conventional drug. Natural and synthetic drugs. Biodrugs and biotechnological drugs. Primary, side, unwanted and toxic effects. Cellular basis of pharmacokinetics (cell barriers and drug transport across membranes). Absorption and routes of drug administration. Distribution, metabolism and elimination of drugs. Interaction between drugs. Pharmacodynamics: receptors and receptor activation theories. Definition of agonist, antagonist and allosteric modulator. Methods to study the biological responses of a drug, dose-response curves, potency and efficacy of a drug. Binding studies and definition of drug affinity. Classes of receptors (G-protein coupled receptor, ionic receptor, receptor associated with an enzymatic activity, intracellular receptor). Mechanisms of signal transduction
Obiettivi Agenda 2030 per lo sviluppo sostenibile	Health and wellbeing

PHARMACOLOGY AND TOXICOLOGY METHODS AND TECHNIQUES

Code	A001522
CFU	1
Teacher	Andrea Alunni Proietti
Learning activities	Caratterizzante
Area	Scienze e tecniche di laboratorio biomedico
Academic discipline	MED/46
Type of study-unit	Obbligatorio (Required)
Contents	• Galenica sterile e non sterile, procedure preparatorie, relative norme e strumentazioni • Norme di buona preparazione, DPI e DMC • Allestimento farmaci antineoplastici e automazione del processo • Preparazione Sacche Nutrizione Parenterale e automazione del processo • Percorso formativo ed addestramento del tecnico sanitario di laboratorio biomedico nella Farmacia Ospedaliera acquisizione di principi teorici e di tecniche lavorative nel campo della farmacia Ospedaliera
Educational objectives	Conoscenza dei metodi di preparazione galenica e chemioterapica magistrale ed officinale, conoscenza di adeguati comportamenti lavorativi e sicurezza all’interno della Farmacia Ospedaliera